KEGG   ORTHOLOGY: K25011
Entry
K25011                      KO                                     

Symbol
nsp1
Name
SARS coronavirus host translation inhibitor nsp1
Pathway
map03230  Viral genome structure
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06141  Translation (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01318  SARS-CoV-2 nsp1 to translation initiation
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
Genes
VP: 1489680-1(nsp1) 43740578-1(nsp1)
Reference
  Authors
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Sturzel CM, Frohlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R
  Title
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
  Journal
Science 369:1249-1255 (2020)
DOI:10.1126/science.abc8665
Reference
  Authors
Yoshimoto FK
  Title
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19.
  Journal
Protein J 39:198-216 (2020)
DOI:10.1007/s10930-020-09901-4
  Sequence
LinkDB

KEGG   ORTHOLOGY: K25016
Entry
K25016                      KO                                     

Symbol
nsp6
Name
SARS coronavirus non-structural protein 6
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06133  RLR signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01319  SARS-CoV-2 nsp6 and ORF6 to RIG-I-IRF7/3 signaling pathway
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
N01322  SARS-CoV-2 nsp6/13 and ORF7a/7b to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K25016  nsp6; SARS coronavirus non-structural protein 6
   03240 Viral replication
    K25016  nsp6; SARS coronavirus non-structural protein 6
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K25016  nsp6; SARS coronavirus non-structural protein 6
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K25016  nsp6; SARS coronavirus non-structural protein 6
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K25016  nsp6; SARS coronavirus non-structural protein 6
Genes
VP: 1489680-6(nsp6) 43740578-6(nsp6)
Reference
  Authors
Yoshimoto FK
  Title
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19.
  Journal
Protein J 39:198-216 (2020)
DOI:10.1007/s10930-020-09901-4
  Sequence
LinkDB

KEGG   ORTHOLOGY: K25022
Entry
K25022                      KO                                     

Symbol
nsp13
Name
SARS coronavirus helicase [EC:3.6.4.12 3.6.4.13]
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06133  RLR signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01310  SARS-CoV-2 nsp13 to RIG-I-IRF7/3 signaling pathway
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
N01322  SARS-CoV-2 nsp6/13 and ORF7a/7b to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K25022  nsp13; SARS coronavirus helicase
   03240 Viral replication
    K25022  nsp13; SARS coronavirus helicase
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K25022  nsp13; SARS coronavirus helicase
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K25022  nsp13; SARS coronavirus helicase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.12  DNA helicase
     K25022  nsp13; SARS coronavirus helicase
    3.6.4.13  RNA helicase
     K25022  nsp13; SARS coronavirus helicase
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K25022  nsp13; SARS coronavirus helicase
Other DBs
GO: 0003678 0003724
Genes
VP: 14254602-12(nsp13) 1489680-12(nsp13) 43740578-12(nsp13)
Reference
  Authors
Yoshimoto FK
  Title
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19.
  Journal
Protein J 39:198-216 (2020)
DOI:10.1007/s10930-020-09901-4
  Sequence
LinkDB

KEGG   ORTHOLOGY: K24579
Entry
K24579                      KO                                     

Symbol
3a
Name
SARS coronavirus accessory protein 3a
Pathway
map03230  Viral genome structure
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24579  3a; SARS coronavirus accessory protein 3a
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24579  3a; SARS coronavirus accessory protein 3a
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24579  3a; SARS coronavirus accessory protein 3a
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24579  3a; SARS coronavirus accessory protein 3a
Genes
VG: 1489669(ORF3a) 43740569(ORF3a) 9714825(ORF3)
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
LinkDB

KEGG   ORTHOLOGY: K24580
Entry
K24580                      KO                                     

Symbol
6
Name
SARS coronavirus accessory protein 6
Pathway
map03230  Viral genome structure
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06133  RLR signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01319  SARS-CoV-2 nsp6 and ORF6 to RIG-I-IRF7/3 signaling pathway
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24580  6; SARS coronavirus accessory protein 6
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24580  6; SARS coronavirus accessory protein 6
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24580  6; SARS coronavirus accessory protein 6
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24580  6; SARS coronavirus accessory protein 6
Genes
VG: 1489673(ORF6) 43740572(ORF6) 9714828(ORF6)
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
LinkDB

KEGG   ORTHOLOGY: K24582
Entry
K24582                      KO                                     

Symbol
7b
Name
SARS coronavirus accessory protein 7b
Pathway
map03230  Viral genome structure
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
N01322  SARS-CoV-2 nsp6/13 and ORF7a/7b to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24582  7b; SARS coronavirus accessory protein 7b
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24582  7b; SARS coronavirus accessory protein 7b
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24582  7b; SARS coronavirus accessory protein 7b
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24582  7b; SARS coronavirus accessory protein 7b
Genes
VG: 1489675(ORF7b) 43740574(ORF7b) 9714830(ORF7b)
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
LinkDB

KEGG   ORTHOLOGY: K24150
Entry
K24150                      KO                                     

Symbol
M
Name
SARS coronavirus membrane protein
Pathway
map03230  Viral genome structure
map05171  Coronavirus disease - COVID-19
Network
nt06122  IFN signaling (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24150  M; SARS coronavirus membrane protein
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24150  M; SARS coronavirus membrane protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24150  M; SARS coronavirus membrane protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24150  M; SARS coronavirus membrane protein
Genes
VG: 1489672(M) 43740571(M) 9714827(M)
Reference
  Authors
Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A, Lowe L, Frace M, DeRisi JL, Chen Q, Wang D, Erdman DD, Peret TC, Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway B, Limor J, McCaustland K, Olsen-Rasmussen M, Fouchier R, Gunther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ, Bellini WJ
  Title
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
  Journal
Science 300:1394-9 (2003)
DOI:10.1126/science.1085952
  Sequence
[vg:1489672]
Reference
  Authors
Lai CW, Chan ZR, Yang DG, Lo WH, Lai YK, Chang MD, Hu YC
  Title
Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein.
  Journal
FEBS Lett 580:3829-34 (2006)
DOI:10.1016/j.febslet.2006.06.003
LinkDB

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