KEGG   MODULE: M00032
Entry
M00032            Pathway   Module                                 
Name
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Definition
K14157 K14085 K00825 (K15791+K00658+K00382) K00252 (K07514,(K07515,K07511) K00022)
Diagram
M00032

Orthology
K14157  
alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9] [RN:R00716 R02313]
K14085  
aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31] [RN:R03102 R03103]
K00825  
2-aminoadipate transaminase [EC:2.6.1.39] [RN:R01939]
K15791  
probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2] [RN:R01933]
K00658  
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide [EC:2.3.1.61] [RN:R01933]
K00382  
dihydrolipoamide dehydrogenase [EC:1.8.1.4] [RN:R01933]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6] [RN:R02488]
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026]
K00022  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975]
Class
Pathway modules; Amino acid metabolism; Lysine metabolism
Pathway
map00310  Lysine degradation
map01100  Metabolic pathways
Reaction
Compound
C00047  L-Lysine
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C04076  L-2-Aminoadipate 6-semialdehyde
C00956  L-2-Aminoadipate
C00322  2-Oxoadipate
C00527  Glutaryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
LinkDB

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