KEGG   MODULE: M00032
Entry
M00032            Pathway   Module                                 
Name
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Definition
K14157 K14085 K00825 (K15791+K00658+K00382) K00252 (K07514,(K07515,K07511) K00022)
Diagram
M00032

Orthology
K14157  
alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9] [RN:R00716 R02313]
K14085  
aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31] [RN:R03102 R03103]
K00825  
2-aminoadipate transaminase [EC:2.6.1.39] [RN:R01939]
K15791  
2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-] [RN:R13166 R13167 R01940 R01933]
K00658  
2-oxoglutarate dehydrogenase E2 component [EC:2.3.1.61] [RN:R02571 R01933]
K00382  
dihydrolipoyl dehydrogenase [EC:1.8.1.4] [RN:R07618 R01933]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6] [RN:R02488]
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K07515,K07511  
enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026]
K00022  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975]
Class
Pathway modules; Amino acid metabolism; Lysine metabolism
Pathway
map00310  Lysine degradation
map01210  2-Oxocarboxylic acid metabolism
map01100  Metabolic pathways
Reaction
R00716  
R02313  
R03102,R03103  
R01939  
R01933  
R01940,R13166+R13167  
R02571  
R07618  
R02488  
R03026  
R01975  
Compound
C00047  L-Lysine
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C04076  L-2-Aminoadipate 6-semialdehyde
C00956  L-2-Aminoadipate
C00322  2-Oxoadipate
C00527  Glutaryl-CoA
C15972  Enzyme N6-(lipoyl)lysine
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
RModule
RM044  2-Oxocarboxylic acid conversion to its CoA derivative
Reference
PMID:32768327
  Authors
Leandro J, Houten SM
  Title
The lysine degradation pathway: Subcellular compartmentalization and enzyme deficiencies.
  Journal
Mol Genet Metab 131:14-22 (2020)
DOI:10.1016/j.ymgme.2020.07.010
LinkDB

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