MODULE: M00032
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Entry
M00032 Pathway Module
Name
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Definition
K14157 K14085 K00825 (K15791+
K00658+
K00382) K00252 (K07514,(K07515,K07511) K00022)
Diagram
Orthology
K14157
alpha-aminoadipic semialdehyde synthase [EC:
1.5.1.8
1.5.1.9
] [RN:
R00716
R02313
]
K14085
aminoadipate-semialdehyde dehydrogenase [EC:
1.2.1.31
] [RN:
R03102
R03103
]
K00825
2-aminoadipate transaminase [EC:
2.6.1.39
] [RN:
R01939
]
K15791
probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:
1.2.4.2
] [RN:
R01933
]
K00658
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide [EC:
2.3.1.61
] [RN:
R01933
]
K00382
dihydrolipoamide dehydrogenase [EC:
1.8.1.4
] [RN:
R01933
]
K00252
glutaryl-CoA dehydrogenase [EC:
1.3.8.6
] [RN:
R02488
]
K07514
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:
4.2.1.17
1.1.1.35
] [RN:
R03026
R01975
]
K07515
,
K07511
enoyl-CoA hydratase [EC:
4.2.1.17
] [RN:
R03026
]
K00022
3-hydroxyacyl-CoA dehydrogenase [EC:
1.1.1.35
] [RN:
R01975
]
Ortholog table
Taxonomy
Module table
Class
Pathway modules; Amino acid metabolism; Lysine metabolism
BRITE hierarchy
Pathway
map00310
Lysine degradation
map01100
Metabolic pathways
Reaction
R00716
C00047
->
C00449
R02313
C00449
->
C04076
R03102
,
R03103
C04076
->
C00956
R01939
C00956
->
C00322
R01933
C00322
->
C00527
R02488
C00527
->
C00877
R03026
C00877
->
C01144
R01975
C01144
->
C00332
Compound
C00047
L-Lysine
C00449
N6-(L-1,3-Dicarboxypropyl)-L-lysine
C04076
L-2-Aminoadipate 6-semialdehyde
C00956
L-2-Aminoadipate
C00322
2-Oxoadipate
C00527
Glutaryl-CoA
C00877
Crotonoyl-CoA
C01144
(S)-3-Hydroxybutanoyl-CoA
C00332
Acetoacetyl-CoA
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