KEGG MODULE: M00104

MODULE: M00104

Entry

M00104            Pathway   Module

Name

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

Definition

K00489 K12408 K07431 K00251 K00037 K00488 K08748 K01796 K10214 K12405 K08764 (K11992,K00659)

Diagram

Orthology

K00489

cholesterol 7alpha-monooxygenase [EC:1.14.14.23] [RN:R01463]

K12408

cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase [EC:1.1.1.181] [RN:R04263]

K07431

sterol 12-alpha-hydroxylase [EC:1.14.14.139] [RN:R04826]

K00251

3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3] [RN:R04823 R04817]

K00037

3-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.50] [RN:R04824 R04825 R04818 R04819]

K00488

cholestanetriol 26-monooxygenase [EC:1.14.15.15] [RN:R04807 R08759 R08761 R04806 R08758 R08760]

K08748

solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7] [RN:R08733 R08738]

K01796

alpha-methylacyl-CoA racemase [EC:5.1.99.4] [RN:R08734 R08739]

K10214

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3] [RN:R08735 R08740]

K12405

(3R)-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase [EC:1.1.1.- 4.2.1.107] [RN:R04813 R04812 R04809 R04810]

K08764

sterol carrier protein 2 [EC:2.3.1.176] [RN:R03719 R04811]

K11992,K00659

acyl-CoA thioesterase 8 [EC:3.1.2.27] [RN:R07296 R03974]

Class

Pathway modules; Lipid metabolism; Sterol biosynthesis

Pathway

map00120

Primary bile acid biosynthesis

map01100

Metabolic pathways

Reaction

R01463

C00187 -> C03594

R04263

C03594 -> C05455

R04826

C05455 -> C17339

R04823

C17339 -> C05453

R04824,R04825

C05453 -> C05454

R04807

C05454 -> C05446

R08759

C05446 -> C01301

R08761

C01301 -> C04722

R08733

C04722 -> C15613

R08734

C15613 -> C17343

R08735

C17343 -> C05460

R04813

C05460 -> C15614

R04812

C15614 -> C05467

R03719

C05467 -> C01794

R07296

C01794 -> C00695

R04817

C05455 -> C05451

R04818,R04819

C05451 -> C05452

R04806

C05452 -> C05444

R08758

C05444 -> C05445

R08760

C05445 -> C04554

R08738

C04554 -> C17345

R08739

C17345 -> C17346

R08740

C17346 -> C05447

R04809

C05447 -> C05448

R04810

C05448 -> C05449

R04811

C05449 -> C05337

R03974

C05337 -> C02528

Compound

C00187

Cholesterol

C03594

7alpha-Hydroxycholesterol

C05455

7alpha-Hydroxycholest-4-en-3-one

C17339

4-Cholesten-7alpha,12alpha-diol-3-one

C05453

7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

C05454

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

C05446

3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane

C01301

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al

C04722

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

C15613

(25R)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-CoA

C17343

(25S)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-CoA

C05460

(24E)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

C15614

(24R,25R)-3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA

C05467

3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA

C01794

Choloyl-CoA

C00695

Cholic acid

C05451

7alpha-Hydroxy-5beta-cholestan-3-one

C05452

3alpha,7alpha-Dihydroxy-5beta-cholestane

C05444

3alpha,7alpha,26-Trihydroxy-5beta-cholestane

C05445

3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al

C04554

3alpha,7alpha-Dihydroxy-5beta-cholestanate

C17345

(25R)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

C17346

(25S)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

C05447

(24E)-3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

C05448

(24R,25R)-3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA

C05449

3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA

C05337

Chenodeoxycholoyl-CoA

C02528

Chenodeoxycholate

LinkDB

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