KEGG   PATHWAY: amq00630
Entry
amq00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Amycolatopsis methanolica
Class
Metabolism; Carbohydrate metabolism
Pathway map
amq00630  Glyoxylate and dicarboxylate metabolism
amq00630

Module
amq_M00012  Glyoxylate cycle [PATH:amq00630]
amq_M00621  Glycine cleavage system [PATH:amq00630]
amq_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:amq00630]
Other DBs
GO: 0046487 0043648
Organism
Amycolatopsis methanolica [GN:amq]
Gene
AMETH_1447  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
AMETH_2995  acs; O-succinylbenzoate-CoA ligase [KO:K01895] [EC:6.2.1.1]
AMETH_3092  butyrate--CoA ligase [KO:K01895] [EC:6.2.1.1]
AMETH_0207  acs; dicarboxylate-CoA ligase PimA [KO:K01895] [EC:6.2.1.1]
AMETH_2249  acs; AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
AMETH_6617  acs; acetate-CoA ligase [KO:K01895] [EC:6.2.1.1]
AMETH_5581  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
AMETH_1591  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
AMETH_1448  aceB; malate synthase [KO:K01638] [EC:2.3.3.9]
AMETH_3421  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
AMETH_2152  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
AMETH_6208  gltA; citrate (Si)-synthase [KO:K01647] [EC:2.3.3.1]
AMETH_6228  gltA; citrate (Si)-synthase [KO:K01647] [EC:2.3.3.1]
AMETH_3020  acn; aconitate hydratase 1 [KO:K27802] [EC:4.2.1.3 4.2.1.99]
AMETH_4462  fadA; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_3756  fadA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_3172  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_2792  fadA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_4504  catF; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_3225  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_4819  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_4823  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_5717  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_4553  atoB; acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_5892  atoB; beta-ketoadipyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
AMETH_5548  atoB; beta-ketoadipyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
AMETH_6959  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMETH_5549  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
AMETH_1366  mutB; methylmalonyl-CoA mutase [KO:K14447] [EC:5.4.99.63]
AMETH_0090  citE; HpcH/HpaI aldolase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
AMETH_0868  acetyl-CoA carboxylase, biotin carboxylase [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
AMETH_0878  pccB; acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
AMETH_0877  acetyl/propionyl-CoA carboxylase, epsilon subunit [KO:K27095]
AMETH_0851  mutA; methylmalonyl-CoA mutase, small subunit [KO:K01847] [EC:5.4.99.2]
AMETH_0852  mutB; methylmalonyl-CoA mutase, small subunit [KO:K01847] [EC:5.4.99.2]
AMETH_3852  glcD; D-lactate dehydrogenase (cytochrome) [KO:K00104] [EC:1.1.99.14]
AMETH_5714  glcD; oxidoreductase [KO:K00104] [EC:1.1.99.14]
AMETH_5754  glcD2; oxidoreductase, FAD-binding [KO:K00104] [EC:1.1.99.14]
AMETH_6826  glcD2; glycolate oxidase, subunit GlcD [KO:K00104] [EC:1.1.99.14]
AMETH_5513  glcD2; putative glycolate oxidase [KO:K00104] [EC:1.1.99.14]
AMETH_3853  glcD; FAD linked oxidase [KO:K11472] [EC:1.1.99.14]
AMETH_3854  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
AMETH_6661  katA; catalase [KO:K03781] [EC:1.11.1.6]
AMETH_3809  serA; glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
AMETH_5400  serA; glycerate dehydrogenase [KO:K00015] [EC:1.1.1.26]
AMETH_6376  gph; putative phosphatase [KO:K01091] [EC:3.1.3.18]
AMETH_5198  hypothetical protein [KO:K01091] [EC:3.1.3.18]
AMETH_4475  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AMETH_1098  glnA2; glutamine synthetase-like protein [KO:K01915] [EC:6.3.1.2]
AMETH_1122  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
AMETH_5216  glnA31; glutamine synthetase catalytic subunit [KO:K01915] [EC:6.3.1.2]
AMETH_5374  glnA4; glutamine synthetase, type III [KO:K01915] [EC:6.3.1.2]
AMETH_4713  glnA4; glutamine synthetase-like protein [KO:K01915] [EC:6.3.1.2]
AMETH_4791  glnA3; glutamine synthetase, type III [KO:K01915] [EC:6.3.1.2]
AMETH_4481  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMETH_6584  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMETH_5370  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AMETH_5369  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AMETH_5332  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMETH_5142  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMETH_2999  gcvH; glycine cleavage system H protein [KO:K02437]
AMETH_4398  gip; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
AMETH_4903  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
AMETH_5710  leuB1; tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
AMETH_1406  eda; 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AMETH_5016  eda; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AMETH_5587  eda; KDPG and KHG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AMETH_5760  kgd; alpha-ketoglutarate decarboxylase [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
AMETH_3396  formate dehydrogenase alpha subunit, selenocysteine-containing protein [KO:K00123] [EC:1.17.1.9]
AMETH_3397  fdh; formate dehydrogenase [KO:K00123] [EC:1.17.1.9]
AMETH_3398  Fe-S-cluster-containing hydrogenase, HybA [KO:K00124]
AMETH_0411  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
AMETH_4492  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
AMETH_2828  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
AMETH_3231  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
amq00010  Glycolysis / Gluconeogenesis
amq00020  Citrate cycle (TCA cycle)
amq00030  Pentose phosphate pathway
amq00053  Ascorbate and aldarate metabolism
amq00071  Fatty acid degradation
amq00230  Purine metabolism
amq00250  Alanine, aspartate and glutamate metabolism
amq00260  Glycine, serine and threonine metabolism
amq00620  Pyruvate metabolism
amq00710  Carbon fixation by Calvin cycle
amq00750  Vitamin B6 metabolism
amq00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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