KEGG   PATHWAY: amq00260
Entry
amq00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Amycolatopsis methanolica
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
amq00260  Glycine, serine and threonine metabolism
amq00260

Module
amq_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:amq00260]
amq_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:amq00260]
amq_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:amq00260]
amq_M00555  Betaine biosynthesis, choline => betaine [PATH:amq00260]
amq_M00621  Glycine cleavage system [PATH:amq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Amycolatopsis methanolica [GN:amq]
Gene
AMETH_6669  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AMETH_6668  asd; aspartate-semialdehyde dehydrogenase, USG-1 related [KO:K00133] [EC:1.2.1.11]
AMETH_1338  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AMETH_1340  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
AMETH_1339  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AMETH_1790  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AMETH_5518  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AMETH_6864  ltaA; threonine aldolase [KO:K01620] [EC:4.1.2.48]
AMETH_4481  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMETH_6584  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AMETH_4903  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
AMETH_0423  gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AMETH_1510  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AMETH_6523  serA; 2-hydroxyacid family dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AMETH_6233  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AMETH_1401  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AMETH_4642  haloacid dehalogenase domain-containing protein hydrolase [KO:K01079] [EC:3.1.3.3]
AMETH_2730  copper amine oxidase domain-containing protein [KO:K00276] [EC:1.4.3.21]
AMETH_1325  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
AMETH_5370  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AMETH_5369  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AMETH_5332  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMETH_5142  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMETH_2999  gcvH; glycine cleavage system H protein [KO:K02437]
AMETH_6429  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AMETH_4499  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AMETH_4497  betB; aldehyde dehydrogenase (acceptor) [KO:K00130] [EC:1.2.1.8]
AMETH_1080  betB; 1-pyrroline dehydrogenase [KO:K00130] [EC:1.2.1.8]
AMETH_4486  FAD dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
AMETH_4484  soxA; glycine cleavage system T protein (aminomethyltransferase) [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AMETH_4482  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AMETH_4485  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AMETH_4483  soxD; sarcosine oxidase subunit alpha [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AMETH_5891  cysM2; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AMETH_4491  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
AMETH_0069  ilvA; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
AMETH_3284  ilvA; putative threonine dehydratase, PLP-dependent [KO:K01754] [EC:4.3.1.19]
AMETH_4390  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AMETH_5885  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AMETH_5070  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AMETH_5071  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
AMETH_5421  trpB; tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
AMETH_6464  ectB; diaminobutyrate/2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
AMETH_6465  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
AMETH_6463  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
AMETH_6462  ectD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
AMETH_4716  amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
amq00010  Glycolysis / Gluconeogenesis
amq00020  Citrate cycle (TCA cycle)
amq00230  Purine metabolism
amq00250  Alanine, aspartate and glutamate metabolism
amq00270  Cysteine and methionine metabolism
amq00290  Valine, leucine and isoleucine biosynthesis
amq00300  Lysine biosynthesis
amq00330  Arginine and proline metabolism
amq00460  Cyanoamino acid metabolism
amq00470  D-Amino acid metabolism
amq00564  Glycerophospholipid metabolism
amq00600  Sphingolipid metabolism
amq00620  Pyruvate metabolism
amq00630  Glyoxylate and dicarboxylate metabolism
amq00640  Propanoate metabolism
amq00680  Methane metabolism
amq00860  Porphyrin metabolism
amq00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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