KEGG   PATHWAY: asao04142
Entry
asao04142                   Pathway                                
Name
Lysosome - Anolis sagrei ordinatus (Brown anole)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
asao04142  Lysosome
asao04142

Other DBs
GO: 0005764
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132760737  SLC17A5; sialin isoform X1 [KO:K12301]
132760856  CD164; sialomucin core protein 24 [KO:K06546]
132760946  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
132761021  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
132761104  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
132761610  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
132762368  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
132762374  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
132762389  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
132762444  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
132762514  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
132763032  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
132763062  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
132763090  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
132763130  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
132763365  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
132763435  CTNS; cystinosin [KO:K12386]
132763448  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
132763551  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
132763638  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
132764030  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
132764125  GBA1; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
132764137  [KO:K01201] [EC:3.2.1.45]
132764182  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
132764183  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
132764528  [KO:K01201] [EC:3.2.1.45]
132764550  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
132764607  [KO:K01201] [EC:3.2.1.45]
132765260  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
132765263  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
132765358  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
132766888  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
132767048  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
132767052  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
132767076  HEXB; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
132767221  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
132767228  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
132767303  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
132767644  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
132767760  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
132767872  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
132767915  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
132767970  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
132767985  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
132767991  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
132768001  MCOLN1; mucolipin-1 [KO:K04992]
132768025  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
132768104  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
132768112  CLTA; clathrin light chain A isoform X1 [KO:K04644]
132768240  CD63; CD63 antigen [KO:K06497]
132768442  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
132768444  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
132768625  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
132768734  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
132768972  GM2A; ganglioside GM2 activator [KO:K12383]
132769026  CLTB; clathrin light chain B isoform X1 [KO:K04645]
132769128  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
132769130  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
132769131  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
132769175  [KO:K01197] [EC:3.2.1.35]
132769384  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
132769746  [KO:K12382]
132769856  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
132770189  [KO:K10532] [EC:2.3.1.78]
132770312  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
132770459  [KO:K12307]
132770471  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
132771108  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
132771114  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
132771119  [KO:K01052] [EC:3.1.1.13]
132771123  [KO:K01052] [EC:3.1.1.13]
132771124  [KO:K01052] [EC:3.1.1.13]
132771175  [KO:K12382]
132771302  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
132771437  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
132771522  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
132771696  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
132772245  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
132772355  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
132772621  [KO:K12402]
132772841  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
132772912  [KO:K12402]
132773086  [KO:K08568] [EC:3.4.18.1]
132773087  [KO:K08568] [EC:3.4.18.1]
132773088  [KO:K08568] [EC:3.4.18.1]
132773089  [KO:K08568] [EC:3.4.18.1]
132773090  [KO:K08568] [EC:3.4.18.1]
132773092  [KO:K08568] [EC:3.4.18.1]
132773301  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
132773350  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
132773612  [KO:K01382] [EC:3.4.23.34]
132773613  [KO:K01382] [EC:3.4.23.34]
132773768  SORT1; sortilin isoform X1 [KO:K12388]
132773825  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
132773939  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
132774079  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
132774650  [KO:K06497]
132774767  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
132774826  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
132775007  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
132775381  [KO:K01382] [EC:3.4.23.34]
132775392  [KO:K01197] [EC:3.2.1.35]
132775602  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
132775845  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
132775919  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
132776001  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
132776192  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
132776680  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
132776717  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
132776778  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
132776860  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
132776960  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
132777068  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
132777178  [KO:K03662]
132777179  [KO:K01197] [EC:3.2.1.35]
132777180  [KO:K01197] [EC:3.2.1.35]
132777357  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
132777460  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
132777620  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
132777955  [KO:K01379] [EC:3.4.23.5]
132777972  CLN3; battenin [KO:K12389]
132778213  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
132778222  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
132778439  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
132778588  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
132780322  [KO:K01319] [EC:3.4.21.20]
132780323  [KO:K01319] [EC:3.4.21.20]
132780517  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
132780641  [KO:K01444] [EC:3.5.1.26]
132780816  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
132780950  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
132781038  [KO:K01365] [EC:3.4.22.15]
132781143  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
132781218  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
132781340  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
132781358  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
132781475  [KO:K01319] [EC:3.4.21.20]
132781558  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
132781622  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
132781875  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
132781887  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
132781902  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
132781977  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
132782142  [KO:K12316] [EC:3.2.1.20]
132782414  LAPTM4A; lysosomal-associated transmembrane protein 4A isoform X1 [KO:K12387]
132782587  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
132782653  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
132783005  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
132783058  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
132783128  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
132783188  [KO:K12391]
132783239  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
132783335  MEAK7; MTOR-associated protein MEAK7 [KO:K27947]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Related
pathway
asao00511  Other glycan degradation
asao00531  Glycosaminoglycan degradation
asao04130  SNARE interactions in vesicular transport
asao04140  Autophagy - animal
asao04144  Endocytosis
KO pathway
ko04142   

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