KEGG   PATHWAY: bcl00260
Entry
bcl00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Alkalihalobacillus clausii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bcl00260  Glycine, serine and threonine metabolism
bcl00260

Module
bcl_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bcl00260]
bcl_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bcl00260]
bcl_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bcl00260]
bcl_M00555  Betaine biosynthesis, choline => betaine [PATH:bcl00260]
bcl_M00621  Glycine cleavage system [PATH:bcl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Alkalihalobacillus clausii [GN:bcl]
Gene
ABC1763  aspartokinase [KO:K00928] [EC:2.7.2.4]
ABC2215  dapG; aspartokinase I alpha and beta subunits [KO:K00928] [EC:2.7.2.4]
ABC2216  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ABC2942  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABC1578  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABC0023  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABC2940  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
ABC2941  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
ABC3183  threonine synthase [KO:K01733] [EC:4.2.3.1]
ABC3863  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ABC0092  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ABC0745  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ABC1431  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
ABC1244  conserved hypothetical protein [KO:K01834] [EC:5.4.2.11]
ABC3018  pgm; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
ABC1843  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ABC1531  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
ABC1932  HAD superfamily hydrolase [KO:K25528] [EC:3.1.3.3]
ABC2494  gcvPA; glycine dehydrogenase [decarboxylating] subunit 1 [KO:K00282] [EC:1.4.4.2]
ABC2493  gcvPB; glycine dehydrogenase [decarboxylating] subunit 2 [KO:K00283] [EC:1.4.4.2]
ABC2495  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ABC2417  pdhD; pyruvate dehydrogenase E3 component [KO:K00382] [EC:1.8.1.4]
ABC2452  lpd; branched-chain alpha-keto acid dehydrogenase E3 component [KO:K00382] [EC:1.8.1.4]
ABC2787  acoL; acetoin dehydrogenase E3 component [KO:K00382] [EC:1.8.1.4]
ABC2986  gcvH; glycine cleavage system H protein [KO:K02437]
ABC0979  gbsB; alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
ABC0980  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ABC1945  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
ABC2306  sdaAA; L-serine dehydratase alpha subunit [KO:K01752] [EC:4.3.1.17]
ABC2307  sdaAB; L-serine dehydratase beta subunit [KO:K01752] [EC:4.3.1.17]
ABC2049  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ABC1181  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ABC1954  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
ABC3598  racX; aspartate racemase [KO:K25316] [EC:5.1.1.10]
ABC1900  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ABC1899  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ABC0335  ectB; diaminobutyrate--pyruvate aminotransferase [KO:K00836] [EC:2.6.1.76]
ABC0334  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
ABC0336  ectC; ectoine synthase [KO:K06720] [EC:4.2.1.108]
ABC3489  L-proline 4-hydroxylase [KO:K10674] [EC:1.14.11.55]
ABC0020  Xaa-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bcl00010  Glycolysis / Gluconeogenesis
bcl00020  Citrate cycle (TCA cycle)
bcl00230  Purine metabolism
bcl00250  Alanine, aspartate and glutamate metabolism
bcl00270  Cysteine and methionine metabolism
bcl00290  Valine, leucine and isoleucine biosynthesis
bcl00300  Lysine biosynthesis
bcl00330  Arginine and proline metabolism
bcl00460  Cyanoamino acid metabolism
bcl00470  D-Amino acid metabolism
bcl00564  Glycerophospholipid metabolism
bcl00600  Sphingolipid metabolism
bcl00620  Pyruvate metabolism
bcl00630  Glyoxylate and dicarboxylate metabolism
bcl00640  Propanoate metabolism
bcl00680  Methane metabolism
bcl00860  Porphyrin metabolism
bcl00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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