KEGG   PATHWAY: bpx00260
Entry
bpx00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia phenoliruptrix
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpx00260  Glycine, serine and threonine metabolism
bpx00260

Module
bpx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpx00260]
bpx_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpx00260]
bpx_M00555  Betaine biosynthesis, choline => betaine [PATH:bpx00260]
bpx_M00621  Glycine cleavage system [PATH:bpx00260]
bpx_M00919  Ectoine degradation, ectoine => aspartate [PATH:bpx00260]
bpx_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpx00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia phenoliruptrix [GN:bpx]
Gene
BUPH_02793  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BUPH_01467  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BUPH_02302  hypothetical protein [KO:K00003] [EC:1.1.1.3]
BUPH_01505  hypothetical protein [KO:K02204] [EC:2.7.1.39]
BUPH_02301  threoninee synthase [KO:K01733] [EC:4.2.3.1]
BUPH_04522  threoninee synthase [KO:K01733] [EC:4.2.3.1]
BUPH_05852  threoninee aldolase [KO:K01620] [EC:4.1.2.48]
BUPH_03042  threoninee aldolase [KO:K01620] [EC:4.1.2.48]
BUPH_00029  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BUPH_04362  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BUPH_01368  alanine-glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BUPH_00979  gyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BUPH_05938  gyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BUPH_06636  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BUPH_02021  gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BUPH_03138  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BUPH_02224  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BUPH_04155  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BUPH_03519  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BUPH_03950  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BUPH_01007  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BUPH_03210  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BUPH_05021  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BUPH_02255  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BUPH_04364  short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BUPH_08495  Putative 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BUPH_01345  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BUPH_01346  threoninee 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BUPH_04947  threoninee 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BUPH_03826  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BUPH_03824  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
BUPH_02878  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BUPH_01908  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BUPH_03825  glycine cleavage system H protein [KO:K02437]
BUPH_05170  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BUPH_00024  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BUPH_00025  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BUPH_00036  Rieske 2Fe-2S family protein [KO:K00479] [EC:1.14.13.251]
BUPH_00037  oxidoreductase FAD-binding protein domain-containing protein [KO:K21832] [EC:1.14.13.251]
BUPH_00032  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
BUPH_06397  hypothetical protein [KO:K21834]
BUPH_00034  electron transfer flavoprotein alpha subunit [KO:K25960]
BUPH_00035  electron transfer flavoprotein beta subunit [KO:K25961]
BUPH_00019  sarcosine oxidase, subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BUPH_00017  sarcosine oxidase, subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BUPH_00020  sarcosine oxidase, subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BUPH_00018  sarcosine oxidase, subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BUPH_00610  type 11 methyltransferase [KO:K18897] [EC:2.1.1.157]
BUPH_03828  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BUPH_00016  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
BUPH_02061  threoninee dehydratase [KO:K01754] [EC:4.3.1.19]
BUPH_02239  threoninee dehydratase [KO:K01754] [EC:4.3.1.19]
BUPH_00898  threoninee dehydratase [KO:K01754] [EC:4.3.1.19]
BUPH_04247  threoninee dehydratase [KO:K01754] [EC:4.3.1.19]
BUPH_08485  putative D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BUPH_04241  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BUPH_02888  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BUPH_01473  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BUPH_01471  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BUPH_08460  ectB; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BUPH_00896  Xaa-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
BUPH_00895  ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
BUPH_01575  aminotransferase class-III [KO:K15785] [EC:2.6.1.76]
BUPH_00892  class III aminotransferase [KO:K15785] [EC:2.6.1.76]
BUPH_00893  succinate-semialdehyde dehydrogenase (NADP+) [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpx00010  Glycolysis / Gluconeogenesis
bpx00020  Citrate cycle (TCA cycle)
bpx00230  Purine metabolism
bpx00250  Alanine, aspartate and glutamate metabolism
bpx00270  Cysteine and methionine metabolism
bpx00290  Valine, leucine and isoleucine biosynthesis
bpx00300  Lysine biosynthesis
bpx00330  Arginine and proline metabolism
bpx00460  Cyanoamino acid metabolism
bpx00470  D-Amino acid metabolism
bpx00564  Glycerophospholipid metabolism
bpx00620  Pyruvate metabolism
bpx00630  Glyoxylate and dicarboxylate metabolism
bpx00640  Propanoate metabolism
bpx00680  Methane metabolism
bpx00860  Porphyrin metabolism
bpx00920  Sulfur metabolism
KO pathway
ko00260   
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