KEGG   PATHWAY: bta04512
Entry
bta04512                    Pathway                                
Name
ECM-receptor interaction - Bos taurus (cow)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
bta04512  ECM-receptor interaction
bta04512

Other DBs
GO: 0005201
Organism
Bos taurus (cow) [GN:bta]
Gene
100138434  LAMA2; laminin subunit alpha-2 [KO:K05637]
100336616  GP6; platelet glycoprotein VI [KO:K06264]
100336873  LAMA3; laminin subunit alpha-3 isoform X4 [KO:K06240]
100337125  DSPP; dentin sialophosphoprotein [KO:K23573]
107131184  FRAS1; LOW QUALITY PROTEIN: extracellular matrix organizing protein FRAS1 [KO:K23379]
280794  FN1; fibronectin precursor [KO:K05717]
280936  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
280958  VWF; von Willebrand factor precursor [KO:K03900]
281052  CD36; platelet glycoprotein 4 [KO:K06259]
281057  CD44; CD44 antigen precursor [KO:K06256]
281069  CHAD; chondroadherin precursor [KO:K06248]
281088  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
281118  DMP1; dentin matrix acidic phosphoprotein 1 precursor [KO:K23328]
281227  HMMR; hyaluronan mediated motility receptor [KO:K06267]
281233  IBSP; bone sialoprotein 2 precursor [KO:K06253]
281439  DAG1; dystroglycan 1 precursor [KO:K06265]
281450  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
281499  SPP1; osteopontin precursor [KO:K06250]
281530  THBS1; thrombospondin-1 precursor [KO:K16857]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
281873  ITGA5; integrin alpha-5 [KO:K06484]
281875  ITGAV; integrin alpha-V precursor [KO:K06487]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
282187  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
282188  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
282191  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
282194  COL6A2; collagen alpha-2(VI) chain precursor [KO:K06238]
282195  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
282564  ITGB5; integrin beta-5 precursor [KO:K06588]
282642  ITGB3; integrin beta-3 precursor [KO:K06493]
282644  ITGB6; integrin beta-6 precursor [KO:K06589]
282654  TNXB; tenascin-X precursor [KO:K06252]
282661  CD47; leukocyte surface antigen CD47 precursor [KO:K06266]
282882  ITGA4; integrin alpha-4 precursor [KO:K06483]
317711  COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237]
338092  THBS2; thrombospondin-2 precursor [KO:K04659]
407107  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
407142  COL2A1; collagen alpha-1(II) chain isoform 1 preproprotein [KO:K19719]
444872  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X8 [KO:K06255]
504323  THBS3; thrombospondin-3 precursor [KO:K04659]
504977  GP1BA; LOW QUALITY PROTEIN: platelet glycoprotein Ib alpha chain [KO:K06261]
505942  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
506387  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
506526  ITGA10; integrin alpha-10 precursor [KO:K06586]
506751  LAMA5; laminin subunit alpha-5 [KO:K06240]
506953  ITGA7; integrin alpha-7 [KO:K06583]
506995  ITGB4; integrin beta-4 precursor [KO:K06525]
507525  VTN; vitronectin precursor [KO:K06251]
508018  FREM1; FRAS1-related extracellular matrix protein 1 precursor [KO:K23380]
508133  SDC4; syndecan-4 [KO:K16338]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
508632  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
511043  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
511422  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
511602  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
511976  ITGA8; integrin alpha-8 [KO:K06584]
513362  NPNT; nephronectin isoform X1 [KO:K06824]
514031  ITGB7; integrin beta-7 precursor [KO:K06590]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
517433  TNN; tenascin-N precursor [KO:K06252]
518526  [KO:K06259]
518914  LAMC3; laminin subunit gamma-3 [KO:K06247]
520030  LAMB1; laminin subunit beta-1 precursor [KO:K05636]
520167  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
522692  GP5; platelet glycoprotein V [KO:K06260]
523526  COL4A6; collagen alpha-6(IV) chain isoform X3 [KO:K06237]
523755  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
525795  AGRN; agrin isoform X2 [KO:K06254]
526409  TNR; tenascin-R precursor [KO:K06252]
527014  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
527601  FREM2; FRAS1-related extracellular matrix protein 2 [KO:K23380]
529670  LAMA4; laminin subunit alpha-4 precursor [KO:K06241]
529759  SDC1; syndecan-1 precursor [KO:K06257]
529939  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
530102  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
530599  [KO:K06243]
530657  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
532127  ITGA9; integrin alpha-9 precursor [KO:K06585]
532572  LAMC1; laminin subunit gamma-1 precursor [KO:K05635]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
535951  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
536286  ITGB8; integrin beta-8 precursor [KO:K06591]
538430  SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
540664  TNC; tenascin precursor [KO:K06252]
541281  THBS4; thrombospondin-4 precursor [KO:K04659]
613958  MEPE; matrix extracellular phosphoglycoprotein precursor [KO:K26442]
617668  GP9; platelet glycoprotein IX [KO:K06263]
785805  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
789493  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
bta04510  Focal adhesion
KO pathway
ko04512   

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