KEGG   PATHWAY: bxe00260
Entry
bxe00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia xenovorans LB400
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bxe00260  Glycine, serine and threonine metabolism
bxe00260

Module
bxe_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bxe00260]
bxe_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bxe00260]
bxe_M00555  Betaine biosynthesis, choline => betaine [PATH:bxe00260]
bxe_M00621  Glycine cleavage system [PATH:bxe00260]
bxe_M00919  Ectoine degradation, ectoine => aspartate [PATH:bxe00260]
bxe_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bxe00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia xenovorans LB400 [GN:bxe]
Gene
Bxe_A1630  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Bxe_B2885  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Bxe_A2381  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Bxe_B2840  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Bxe_A2380  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Bxe_B2204  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Bxe_A1314  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Bxe_B1585  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bxe_A3914  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bxe_B3001  Serine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Bxe_B0983  putative 2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
Bxe_B1490  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bxe_A4269  Putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bxe_B1979  Putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bxe_C0770  Putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bxe_A1982  Putative 2-ketogluconate 6-phosphate reductase, TkrA [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bxe_A1055  Putative 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bxe_A2298  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Bxe_B0981  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Bxe_A4181  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Bxe_A0613  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Bxe_B2128  putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bxe_B1744  putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bxe_A4423  Putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bxe_A0976  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Bxe_A2331  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Bxe_A3915  Putative short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
Bxe_B3021  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Bxe_B3020  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Bxe_B1535  Putative flavin monoamine oxidase-related protein [KO:K00274] [EC:1.4.3.4]
Bxe_A0054  Glycine cleavage system P-protein [KO:K00281] [EC:1.4.4.2]
Bxe_A0056  Glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Bxe_C0853  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bxe_B0582  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bxe_A1543  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bxe_A2810  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bxe_A0055  Glycine cleavage H-protein [KO:K02437]
Bxe_A3227  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Bxe_B1592  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Bxe_B1591  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bxe_A3526  Putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bxe_B1578  iron-sulfur Rieske protein [KO:K00479] [EC:1.14.13.251]
Bxe_B1577  putative ferredoxin oxidoreductase protein [KO:K21832] [EC:1.14.13.251]
Bxe_B1582  NADH-flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
Bxe_B1581  putative membrane protein [KO:K21834]
Bxe_B1580  putative electron transfer flavoprotein alpha-subunit [KO:K25960]
Bxe_B1579  putative electron transfer flavoprotein beta-subunit [KO:K25961]
Bxe_B1598  Sarcosine oxidase, alpha subunit, heterotetrameric [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Bxe_B1600  Sarcosine oxidase, beta subunit, heterotetrameric [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Bxe_B1597  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Bxe_B1599  putative sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Bxe_A0052  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Bxe_B0082  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Bxe_B1601  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Bxe_C0056  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Bxe_A2039  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Bxe_A4054  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Bxe_A2315  Putative amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]
Bxe_A1530  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
Bxe_B2879  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Bxe_B2881  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Bxe_C0063  Putative peptidase [KO:K15783] [EC:3.5.4.44]
Bxe_C0058  Conserved hypothetical protein [KO:K15784] [EC:3.5.1.125]
Bxe_C0061  aminotransferase [KO:K15785] [EC:2.6.1.76]
Bxe_C0060  succinate semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bxe00010  Glycolysis / Gluconeogenesis
bxe00020  Citrate cycle (TCA cycle)
bxe00230  Purine metabolism
bxe00250  Alanine, aspartate and glutamate metabolism
bxe00270  Cysteine and methionine metabolism
bxe00290  Valine, leucine and isoleucine biosynthesis
bxe00300  Lysine biosynthesis
bxe00330  Arginine and proline metabolism
bxe00460  Cyanoamino acid metabolism
bxe00470  D-Amino acid metabolism
bxe00564  Glycerophospholipid metabolism
bxe00600  Sphingolipid metabolism
bxe00620  Pyruvate metabolism
bxe00630  Glyoxylate and dicarboxylate metabolism
bxe00640  Propanoate metabolism
bxe00680  Methane metabolism
bxe00860  Porphyrin metabolism
bxe00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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