KEGG   PATHWAY: cel00230
Entry
cel00230                    Pathway                                
Name
Purine metabolism - Caenorhabditis elegans (nematode)
Class
Metabolism; Nucleotide metabolism
Pathway map
cel00230  Purine metabolism
cel00230

Module
cel_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cel00230]
cel_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cel00230]
cel_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cel00230]
cel_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cel00230]
cel_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cel00230]
cel_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cel00230]
Other DBs
GO: 0006163 0042278
Organism
Caenorhabditis elegans (nematode) [GN:cel]
Gene
CELE_AH6.1  gcy-1; Receptor-type guanylate cyclase gcy-1 [KO:K01769] [EC:4.6.1.2]
CELE_B0286.3  paic-1; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
CELE_C03C10.3  rnr-2; Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
CELE_C06B3.8  gcy-32; Soluble guanylate cyclase gcy-32 [KO:K12319] [EC:4.6.1.2]
CELE_C06G3.5  adah-1; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
CELE_C27H5.1  pdl-1; Phosphodiesterase delta-like protein [KO:K13758]
CELE_C29E4.8  let-754; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
CELE_C32E12.2  pde-5; putative 3',5'-cyclic phosphodiesterase pde-5 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
CELE_C34F11.3  ampd-1; AMP deaminase [KO:K01490] [EC:3.5.4.6]
CELE_C37H5.6  adss-1; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
CELE_C46E1.2  gcy-36; Soluble guanylate cyclase gcy-36 [KO:K12319] [EC:4.6.1.2]
CELE_C49H3.1  gcy-8; Receptor-type guanylate cyclase gcy-8 [KO:K01769] [EC:4.6.1.2]
CELE_C55F2.1  atic-1; Phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
CELE_E01F3.1  pde-3; putative 3',5'-cyclic phosphodiesterase pde-3 [KO:K19021] [EC:3.1.4.17]
CELE_E02H1.6  E02H1.6; Adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
CELE_EEED8.8  ndx-6; Putative nudix hydrolase 6 [KO:K13988] [EC:3.6.1.13]
CELE_F08B1.2  gcy-12; Receptor-type guanylate cyclase gcy-12 [KO:K01769] [EC:4.6.1.2]
CELE_F08C6.6  apy-1; Apyrase apy-1 [KO:K12304] [EC:3.6.1.6]
CELE_F10F2.2  pfas-1; putative phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
CELE_F17C8.1  acy-1; adenylate cyclase [KO:K08049] [EC:4.6.1.1]
CELE_F21H7.9  gcy-20; Receptor-type guanylate cyclase gcy-20 [KO:K01769] [EC:4.6.1.2]
CELE_F22E5.3  gcy-21; Receptor-type guanylate cyclase gcy-21 [KO:K01769] [EC:4.6.1.2]
CELE_F25H2.5  ndk-1; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
CELE_F32D1.5  gmpr-1; GMP reductase [KO:K00364] [EC:1.7.1.7]
CELE_F38B2.4  F38B2.4; Adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
CELE_F38B6.4  F38B6.4; Phosphoribosylglycinamide formyltransferase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
CELE_F45F2.9  F45F2.9; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
CELE_F55B11.1  xdh-1; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
CELE_F57F5.2  gcy-33; Soluble guanylate cyclase gcy-33 [KO:K01769] [EC:4.6.1.2]
CELE_K02D7.1  pnp-1; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
CELE_K08H10.4  uda-1; Nucleoside-diphosphatase uda-1 [KO:K01511] [EC:3.6.1.6]
CELE_M04G12.3  gcy-34; Soluble guanylate cyclase gcy-34 [KO:K01769] [EC:4.6.1.2]
CELE_M106.4  gmps-1; putative GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
CELE_R05F9.6  pgm-1; phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) [KO:K01835] [EC:5.4.2.2]
CELE_R05G6.5  R05G6.5; Uroporphyrinogen-III synthase [KO:K00940] [EC:2.7.4.6]
CELE_R06C7.5  adsl-1; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
CELE_R07E4.4  mig-23; Nucleoside-diphosphatase mig-23 [KO:K12305] [EC:3.6.1.6]
CELE_R07H5.8  adk-1; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
CELE_R08D7.6  pde-2; putative 3',5'-cyclic phosphodiesterase pde-2 [KO:K18283] [EC:3.1.4.17]
CELE_R09H10.3  R09H10.3; putative 5-hydroxyisourate hydrolase R09H10.3 [KO:K07127] [EC:3.5.2.17]
CELE_R134.1  gcy-3; Receptor-type guanylate cyclase gcy-3 [KO:K01769] [EC:4.6.1.2]
CELE_R151.2  prps-1; Ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
CELE_R153.1  pde-4; putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [KO:K13293] [EC:3.1.4.53]
CELE_T01A4.1  gcy-28; Receptor-type guanylate cyclase gcy-28 [KO:K12323] [EC:4.6.1.2]
CELE_T03F1.8  guk-1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
CELE_T04A8.5  ppat-1; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
CELE_T04D3.3  pde-1; putative 3',5'-cyclic phosphodiesterase pde-1 [KO:K13755] [EC:3.1.4.17]
CELE_T04D3.4  gcy-35; Soluble guanylate cyclase gcy-35 [KO:K12319] [EC:4.6.1.2]
CELE_T07D1.1  gcy-31; Soluble guanylate cyclase gcy-31 [KO:K01769] [EC:4.6.1.2]
CELE_T14G10.1  pps-1; Sulfate adenylyltransferase [KO:K13811] [EC:2.7.7.4 2.7.1.25]
CELE_T19B4.3  aprt-1; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
CELE_T22D1.3  T22D1.3; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
CELE_T23G5.1  rnr-1; Ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
CELE_T26C12.4  gcy-23; Receptor-type guanylate cyclase gcy-23 [KO:K01769] [EC:4.6.1.2]
CELE_W03F11.2  gcy-17; Receptor-type guanylate cyclase gcy-17 [KO:K12323] [EC:4.6.1.2]
CELE_Y105E8B.5  hprt-1; Hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
CELE_Y37H9A.6  ndx-4; Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
CELE_Y43F4B.5  pgm-2; Phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
CELE_Y71H10B.1  ntfc-1; Cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
CELE_Y95B8A.10  pde-6; Phosphodiesterase [KO:K18437] [EC:3.1.4.53]
CELE_ZC239.7  gcy-15; Receptor-type guanylate cyclase gcy-15 [KO:K01769] [EC:4.6.1.2]
CELE_ZC395.7  hap-1; Inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
CELE_ZC412.2  gcy-14; Receptor-type guanylate cyclase gcy-14 [KO:K01769] [EC:4.6.1.2]
CELE_ZK563.7  ZK563.7; Apyrase [KO:K12304] [EC:3.6.1.6]
CELE_ZK673.2  ZK673.2; putative adenylate kinase isoenzyme ZK673.2 [KO:K00939] [EC:2.7.4.3]
CELE_ZK697.8  ZK697.8; putative 5-hydroxyisourate hydrolase ZK697.8 [KO:K07127] [EC:3.5.2.17]
CELE_ZK896.8  gcy-18; Receptor-type guanylate cyclase gcy-18 [KO:K01769] [EC:4.6.1.2]
CELE_ZK909.3  ZK909.3; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
CELE_ZK970.6  gcy-5; Receptor-type guanylate cyclase gcy-5 [KO:K01769] [EC:4.6.1.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cel00030  Pentose phosphate pathway
cel00220  Arginine biosynthesis
cel00250  Alanine, aspartate and glutamate metabolism
cel00260  Glycine, serine and threonine metabolism
cel00340  Histidine metabolism
cel00630  Glyoxylate and dicarboxylate metabolism
cel00730  Thiamine metabolism
cel00740  Riboflavin metabolism
cel00790  Folate biosynthesis
KO pathway
ko00230   

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