KEGG   PATHWAY: csyr00564
Entry
csyr00564                   Pathway                                
Name
Glycerophospholipid metabolism - Carlito syrichta (Philippine tarsier)
Class
Metabolism; Lipid metabolism
Pathway map
csyr00564  Glycerophospholipid metabolism
csyr00564

Module
csyr_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:csyr00564]
csyr_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:csyr00564]
csyr_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:csyr00564]
Other DBs
GO: 0006650
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249206  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
103249739  ACHE; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
103249839  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103249868  [KO:K16342] [EC:3.1.1.4]
103250386  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
103250541  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
103250572  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
103251019  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
103252151  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103252209  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
103252240  PNPLA6; LOW QUALITY PROTEIN: neuropathy target esterase [KO:K14676] [EC:3.1.1.5]
103252521  DGKG; diacylglycerol kinase gamma isoform X2 [KO:K00901] [EC:2.7.1.107]
103252585  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
103253813  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
103254049  GPD2; LOW QUALITY PROTEIN: glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
103254437  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103254779  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
103255088  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
103255222  ETNK1; LOW QUALITY PROTEIN: ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
103255249  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
103255567  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
103255840  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
103255848  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103256118  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103256271  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
103257307  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
103257512  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
103257623  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
103257732  PLD4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
103258321  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
103258392  [KO:K13618] [EC:3.1.1.111]
103258525  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103258557  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
103258827  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
103259243  AGPAT3; LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103259561  [KO:K00901] [EC:2.7.1.107]
103260465  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
103260506  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
103260868  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
103261400  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
103261862  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103261901  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103261914  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
103262503  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103262773  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
103262909  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
103263213  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103263757  [KO:K00901] [EC:2.7.1.107]
103263877  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
103263881  SAMD8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
103264478  LYPLA2; acyl-protein thioesterase 2 isoform X5 [KO:K06130] [EC:3.1.1.5]
103264584  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [KO:K00006] [EC:1.1.1.8]
103265018  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
103265089  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
103265164  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
103266008  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X2 [KO:K06124] [EC:3.1.3.75]
103266396  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
103266411  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
103266604  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
103266674  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
103267254  [KO:K01047] [EC:3.1.1.4]
103267522  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
103267835  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
103267906  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
103267947  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103268194  PLA2G15; group XV phospholipase A2 isoform X2 [KO:K06129] [EC:3.1.1.5]
103268200  LCAT; phosphatidylcholine-sterol acyltransferase isoform X2 [KO:K00650] [EC:2.3.1.43]
103268236  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
103268264  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
103268709  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
103269504  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
103269942  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
103270621  SELENOI; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
103270796  [KO:K13515] [EC:2.3.1.23 2.3.1.-]
103271261  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
103271309  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X3 [KO:K13509] [EC:2.3.1.51]
103271465  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
103271728  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
103271798  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103272332  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
103272468  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
103272926  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
103273217  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
103273316  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103273317  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
103273319  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103273326  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103273327  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103274013  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
103274096  [KO:K13517] [EC:2.3.1.51 2.3.1.-]
103274205  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
103274409  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
103274574  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
103274947  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
103274969  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
103275746  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103276388  [KO:K13509] [EC:2.3.1.51]
103276457  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
103276554  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103276736  [KO:K18693] [EC:3.6.1.75 3.1.3.4]
103277369  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
csyr00010  Glycolysis / Gluconeogenesis
csyr00260  Glycine, serine and threonine metabolism
csyr00561  Glycerolipid metabolism
csyr00562  Inositol phosphate metabolism
csyr00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
csyr00565  Ether lipid metabolism
csyr00620  Pyruvate metabolism
KO pathway
ko00564   

DBGET integrated database retrieval system