KEGG   PATHWAY: csyr00260
Entry
csyr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Carlito syrichta (Philippine tarsier)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
csyr00260  Glycine, serine and threonine metabolism
csyr00260

Module
csyr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:csyr00260]
csyr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:csyr00260]
csyr_M00555  Betaine biosynthesis, choline => betaine [PATH:csyr00260]
csyr_M00621  Glycine cleavage system [PATH:csyr00260]
csyr_M00974  Betaine metabolism, animals, betaine => glycine [PATH:csyr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249783  [KO:K15789] [EC:1.1.1.103]
103250081  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
103254414  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
103255488  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
103255928  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
103255933  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
103256085  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
103256090  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
103256358  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103256864  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
103257200  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
103257676  [KO:K00382] [EC:1.8.1.4]
103258210  [KO:K02437]
103258400  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
103259594  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
103260572  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
103262281  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
103262926  [KO:K01834] [EC:5.4.2.11]
103263536  [KO:K00639] [EC:2.3.1.29]
103264843  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
103264924  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
103264960  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
103264977  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
103265367  [KO:K01697] [EC:4.2.1.22]
103265505  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
103266554  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
103267155  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
103267381  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
103268550  GNMT; LOW QUALITY PROTEIN: glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
103270462  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103270467  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103270699  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
103270707  AOC2; LOW QUALITY PROTEIN: retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
103271037  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
103271899  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
103272713  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
103272932  [KO:K01620] [EC:4.1.2.48]
103273376  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
103274598  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103275724  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
103276728  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
103277285  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
csyr00010  Glycolysis / Gluconeogenesis
csyr00020  Citrate cycle (TCA cycle)
csyr00230  Purine metabolism
csyr00250  Alanine, aspartate and glutamate metabolism
csyr00270  Cysteine and methionine metabolism
csyr00290  Valine, leucine and isoleucine biosynthesis
csyr00330  Arginine and proline metabolism
csyr00470  D-Amino acid metabolism
csyr00564  Glycerophospholipid metabolism
csyr00600  Sphingolipid metabolism
csyr00620  Pyruvate metabolism
csyr00630  Glyoxylate and dicarboxylate metabolism
csyr00640  Propanoate metabolism
csyr00860  Porphyrin metabolism
csyr00920  Sulfur metabolism
KO pathway
ko00260   

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