KEGG   PATHWAY: dsi04148
Entry
dsi04148                    Pathway                                
Name
Efferocytosis - Drosophila simulans
Class
Cellular Processes; Transport and catabolism
Pathway map
dsi04148  Efferocytosis
dsi04148

Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD10073  Dsim_GD10073; uncharacterized protein, isoform B [KO:K23285]
Dsimw501_GD12305  Dsim_GD12305; uncharacterized protein [KO:K04459] [EC:3.1.3.16 3.1.3.48]
Dsimw501_GD12885  Dsim_GD12885; uncharacterized protein, isoform B [KO:K16343] [EC:3.1.1.4]
Dsimw501_GD13056  Dsim_GD13056; uncharacterized protein [KO:K04392]
Dsimw501_GD13124  Dsim_GD13124; uncharacterized protein [KO:K20178]
Dsimw501_GD13447  Dsim_GD13447; uncharacterized protein, isoform C [KO:K24068]
Dsimw501_GD13487  Dsim_GD13487; uncharacterized protein [KO:K04392]
Dsimw501_GD13722  Dsim_GD13722; uncharacterized protein [KO:K04718] [EC:2.7.1.91]
Dsimw501_GD14194  Dsim_GD14194; uncharacterized protein, isoform D [KO:K04438]
Dsimw501_GD14349  Dsim_GD14349; uncharacterized protein [KO:K19499]
Dsimw501_GD15360  Dsim_GD15360; uncharacterized protein [KO:K01581] [EC:4.1.1.17]
Dsimw501_GD15368  Dsim_GD15368; uncharacterized protein, isoform B [KO:K04550]
Dsimw501_GD15481  Dsim_GD15481; uncharacterized protein, isoform B [KO:K06704] [EC:3.4.24.81]
Dsimw501_GD15992  Dsim_hop; hop [KO:K04447] [EC:2.7.10.2]
Dsimw501_GD16235  Dsim_GD16235; uncharacterized protein, isoform B [KO:K04443] [EC:2.7.11.1]
Dsimw501_GD16510  Dsim_GD16510; uncharacterized protein [KO:K01476] [EC:3.5.3.1]
Dsimw501_GD16945  Dsim_Dsor1; Dsor1, isoform C [KO:K04368] [EC:2.7.12.2]
Dsimw501_GD17022  Dsim_GD17022; uncharacterized protein [KO:K04718] [EC:2.7.1.91]
Dsimw501_GD17261  Dsim_GD17261; uncharacterized protein, isoform A [KO:K09355]
Dsimw501_GD17275  Dsim_GD17275; uncharacterized protein [KO:K26811]
Dsimw501_GD17392  Dsim_GD17392; uncharacterized protein [KO:K05870]
Dsimw501_GD17447  Dsim_GD17447; uncharacterized protein [KO:K20182]
Dsimw501_GD18318  Dsim_GD18318; uncharacterized protein, isoform A [KO:K04441] [EC:2.7.11.24]
Dsimw501_GD18319  Dsim_GD18319; uncharacterized protein [KO:K04441] [EC:2.7.11.24]
Dsimw501_GD18603  Dsim_GD18603; uncharacterized protein [KO:K20180]
Dsimw501_GD18847  Dsim_GD18847; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD18848  Dsim_GD18848; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD20189  Dsim_GD20189; uncharacterized protein [KO:K20183]
Dsimw501_GD20281  Dsim_GD20281; uncharacterized protein [KO:K04397] [EC:3.4.22.60]
Dsimw501_GD20506  Dsim_GD20506; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD20777  Dsim_GD20777; uncharacterized protein [KO:K08057]
Dsimw501_GD20793  Dsim_GD20793; uncharacterized protein, isoform A [KO:K04392]
Dsimw501_GD20825  Dsim_GD20825; uncharacterized protein [KO:K09097]
Dsimw501_GD21040  Dsim_GD21040; uncharacterized protein, isoform B [KO:K13708]
Dsimw501_GD21052  Dsim_GD21052; uncharacterized protein [KO:K07897]
Dsimw501_GD21343  Dsim_GD21343; uncharacterized protein [KO:K04392]
Dsimw501_GD21457  Dsim_GD21457; uncharacterized protein, isoform B [KO:K06704] [EC:3.4.24.81]
Dsimw501_GD21467  Dsim_GD21467; uncharacterized protein [KO:K04397] [EC:3.4.22.60]
Dsimw501_GD21492  Dsim_GD21492; uncharacterized protein [KO:K06059] [EC:3.4.24.86]
Dsimw501_GD21504  Dsim_sima; hypothetical protein [KO:K08268]
Dsimw501_GD21702  Dsim_GD21702; uncharacterized protein [KO:K06129] [EC:3.1.1.5]
Dsimw501_GD22241  Dsim_GD22241; uncharacterized protein, isoform A [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD22841  Dsim_GD22841; uncharacterized protein, isoform A [KO:K07888]
Dsimw501_GD22901  Dsim_GD22901; uncharacterized protein [KO:K00411] [EC:7.1.1.8]
Dsimw501_GD23714  Dsim_GD23714; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD23817  Dsim_GD23817; uncharacterized protein [KO:K12366]
Dsimw501_GD23867  Dsim_GD23867; uncharacterized protein [KO:K11411] [EC:2.3.1.286]
Dsimw501_GD23919  Dsim_GD23919; uncharacterized protein [KO:K04441] [EC:2.7.11.24]
Dsimw501_GD23961  Dsim_GD23961; uncharacterized protein, isoform A [KO:K07881]
Dsimw501_GD24493  Dsim_GD24493; uncharacterized protein [KO:K26934]
Dsimw501_GD24721  Dsim_dor; deep orange [KO:K20181]
Dsimw501_GD24731  Dsim_GD24731; uncharacterized protein [KO:K07293] [EC:3.1.3.48]
Dsimw501_GD24836  Dsim_GD24836; uncharacterized protein, isoform B [KO:K26934]
Dsimw501_GD24968  Dsim_GD24968; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD24994  Dsim_GD24994; uncharacterized protein, isoform F [KO:K05853] [EC:7.2.2.10]
Dsimw501_GD25321  Dsim_GD25321; uncharacterized protein, isoform A [KO:K05725] [EC:2.7.10.2]
Dsimw501_GD25632  Dsim_GD25632; uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD25762  Dsim_GD25762; uncharacterized protein, isoform B [KO:K14802] [EC:7.6.2.1]
Dsimw501_GD25979  Dsim_GD25979; uncharacterized protein, isoform B [KO:K08765] [EC:2.3.1.21]
Dsimw501_GD26811  Dsim_GD26811; uncharacterized protein, isoform F [KO:K20184]
Dsimw501_GD27160  Dsim_GD27160; uncharacterized protein, isoform B [KO:K26935]
Dsimw501_GD27230  Dsim_GD27230; uncharacterized protein [KO:K01581] [EC:4.1.1.17]
Dsimw501_GD27396  Dsim_GD27396; uncharacterized protein [KO:K20179]
Dsimw501_GD28358  Dsim_GD28358; uncharacterized protein, isoform A [KO:K01052] [EC:3.1.1.13]
Dsimw501_GD28502  Dsim_GD28502; uncharacterized protein [KO:K04371] [EC:2.7.11.24]
Dsimw501_GD28701  Dsim_GD28701; uncharacterized protein, isoform P [KO:K04515] [EC:2.7.11.17]
Dsimw501_GD29324  Dsim_GD29324; uncharacterized protein [KO:K20179]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
dsi00010  Glycolysis / Gluconeogenesis
dsi04140  Autophagy - animal
dsi04145  Phagosome
KO pathway
ko04148   

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