KEGG   PATHWAY: ece00230
Entry
ece00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O157:H7 EDL933 (EHEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ece00230  Purine metabolism
ece00230

Module
ece_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ece00230]
ece_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ece00230]
ece_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ece00230]
ece_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ece00230]
ece_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ece00230]
ece_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ece00230]
ece_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ece00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O157:H7 EDL933 (EHEC) [GN:ece]
Gene
Z0058  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
Z0114  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
Z0136  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Z0171  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
Z0299  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
Z0350  yagR; orf, hypothetical protein [KO:K11177] [EC:1.17.1.4]
Z0351  yagS; orf, hypothetical protein [KO:K11178] [EC:1.17.1.4]
Z0352  yagT; putative xanthine dehydrogenase [KO:K13483]
Z0412  yahI; putative kinase [KO:K00926] [EC:2.7.2.2]
Z0487  yaiE; orf, hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
Z0586  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
Z0591  adk; adenylate kinase activity; pleiotropic effects on glycerol-3-phosphate acyltransferase activity [KO:K00939] [EC:2.7.4.3]
Z0596  gsk; inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
Z0599  ushA; UDP-sugar hydrolase (5'-nucleotidase) [KO:K11751] [EC:3.1.3.5 3.6.1.45]
Z0659  ybbT; orf, hypothetical protein [KO:K01483] [EC:4.3.2.3]
Z0666  [KO:K01466] [EC:3.5.2.5]
Z0667  [KO:K01466] [EC:3.5.2.5]
Z0670  ylbA; orf, hypothetical protein [KO:K14977] [EC:3.5.3.26]
Z0671  ylbB; putative hydantoin utilization protein [KO:K02083] [EC:3.5.3.9]
Z0672  ylbC; putative malate dehydrogenase [KO:K00073] [EC:1.1.1.350]
Z0676  arcC; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
Z0677  purK; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit [KO:K01589] [EC:6.3.4.18]
Z0678  purE; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
Z0822  nagD; N-acetylglucosamine metabolism [KO:K02566] [EC:3.1.3.5]
Z0837  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
Z1143  ureA; putative urease structural subunit A (gamma) [KO:K01430] [EC:3.5.1.5]
Z1144  ureB; putative urease structural subunit B (beta) [KO:K01429] [EC:3.5.1.5]
Z1145  ureC; putative urease structural subunit C (alpha) [KO:K01428] [EC:3.5.1.5]
Z1582  ureA_2; putative urease structural subunit A (gamma) [KO:K01430] [EC:3.5.1.5]
Z1583  ureB_2; putative urease structural subunit B (beta) [KO:K01429] [EC:3.5.1.5]
Z1584  ureC_2; putative urease structural subunit C (alpha) [KO:K01428] [EC:3.5.1.5]
Z1860  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Z1978  prsA; phosphoribosylpyrophosphate synthetase [KO:K00948] [EC:2.7.6.1]
Z2628  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
Z2901  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
Z3062  [KO:K07127] [EC:3.5.2.17]
Z3139  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
Z3489  nrdA; ribonucleoside diphosphate reductase 1, alpha subunit, B1 [KO:K00525] [EC:1.17.4.1]
Z3491  nrdB; ribonucleoside diphosphage reductase 1, beta subunit, B2 [KO:K00526] [EC:1.17.4.1]
Z3552  [KO:K08722] [EC:3.1.3.89]
Z3574  purF; amidophosphoribosyltransferase = PRPP amidotransferase [KO:K00764] [EC:2.4.2.14]
Z3735  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase [KO:K01923] [EC:6.3.2.6]
Z3762  purM; phosphoribosylaminoimidazole synthetase = AIR synthetase [KO:K01933] [EC:6.3.3.1]
Z3763  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
Z3765  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Z3771  guaA; GMP synthetase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
Z3772  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
Z3781  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
Z3835  purL; phosphoribosylformyl-glycineamide synthetase = FGAM synthetase [KO:K01952] [EC:6.3.5.3]
Z3887  yfiH; orf, hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Z3977  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
Z3978  nrdF; ribonucleoside-diphosphate reductase 2, beta chain [KO:K00526] [EC:1.17.4.1]
Z4052  surE; survival protein [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Z4058  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
Z4059  cysN; ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 1, probably a GTPase [KO:K00956] [EC:2.7.7.4]
Z4060  cysD; ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2 [KO:K00957] [EC:2.7.7.4]
Z4096  mazG; orf, hypothetical protein [KO:K04765] [EC:3.6.1.9]
Z4099  relA; (p)ppGpp synthetase I (GTP pyrophosphokinase); regulation of RNA synthesis; stringent factor [KO:K00951] [EC:2.7.6.5]
Z4112  ygdH; orf, hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
Z4205  [KO:K00087] [EC:1.17.1.4]
Z4206  ygeT; putative dehydrogenase [KO:K13479] [EC:1.17.1.4]
Z4207  [KO:K13480]
Z4213  yqeA; putative kinase [KO:K00926] [EC:2.7.2.2]
Z4222  ygfP; orf, hypothetical protein [KO:K01487] [EC:3.5.4.3]
Z4299  yggV; putative ribosomal protein [KO:K01519] [EC:3.6.1.66]
Z4389  icc; regulator of lacZ [KO:K03651] [EC:3.1.4.53]
Z4391  yqiE; orf, hypothetical protein [KO:K01515] [EC:3.6.1.13 3.6.1.-]
Z4751  yrfE; orf, hypothetical protein [KO:K08312] [EC:3.6.1.-]
Z4753  yrfG; putative phosphatase [KO:K20881] [EC:3.1.3.-]
Z5074  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
Z5076  spoT; (p)ppGpp synthetase II; also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Z5155  yicP; probable adenine deaminase (synthesis xanthine) [KO:K01486] [EC:3.5.4.2]
Z5289  gppA; guanosine pentaphosphatase; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Z5322  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
Z5582  purD; phosphoribosylglycinamide synthetase = GAR synthetase [KO:K01945] [EC:6.3.4.13]
Z5583  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase = AICAR formyltransferase; IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Z5784  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Z5824  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
Z5848  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
Z5985  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
Z5986  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
Z5996  yjjX; orf, hypothetical protein [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ece00030  Pentose phosphate pathway
ece00220  Arginine biosynthesis
ece00250  Alanine, aspartate and glutamate metabolism
ece00260  Glycine, serine and threonine metabolism
ece00340  Histidine metabolism
ece00630  Glyoxylate and dicarboxylate metabolism
ece00730  Thiamine metabolism
ece00740  Riboflavin metabolism
ece00790  Folate biosynthesis
KO pathway
ko00230   

DBGET integrated database retrieval system