KEGG   PATHWAY: eju04142
Entry
eju04142                    Pathway                                
Name
Lysosome - Eumetopias jubatus (Steller sea lion)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
eju04142  Lysosome
eju04142

Other DBs
GO: 0005764
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114200378  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
114201352  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114211706  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
114220227  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114216467  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
114199499  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
114220883  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
114201596  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
114208485  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
114215563  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114224275  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
114209487  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
114206378  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
114208810  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
114219468  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
114223138  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
114217461  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
114199708  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
114220325  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
114222020  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
114220435  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
114217879  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
114201245  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
114197248  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
114223349  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
114223369  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114223380  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114223381  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114223385  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
114210203  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
114197270  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
114220358  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
114197916  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
114199563  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
114205285  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
114219328  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
114202973  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
114202977  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
114212212  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
114216122  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
114198641  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
114197782  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
114218390  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
114201350  NAGLU; alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
114204706  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
114214374  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
114217132  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
114222732  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
114217593  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
114206354  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
114199327  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
114197695  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
114222263  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
114225044  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
114225120  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
114225130  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
114210572  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
114210600  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
114210699  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
114218508  ARSA; LOW QUALITY PROTEIN: arylsulfatase A [KO:K01134] [EC:3.1.6.8]
114217566  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
114216314  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
114199244  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
114214906  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
114202770  LOW QUALITY PROTEIN: iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
114199013  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
114216239  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
114210248  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
114203325  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
114208504  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
114197773  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
114215359  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
114197760  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
114219382  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
114206151  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
114206131  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
114214178  PSAP; prosaposin isoform X1 [KO:K12382]
114211895  GM2A; ganglioside GM2 activator [KO:K12383]
114224196  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
114222151  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
114196599  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
114196947  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
114206975  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
114225317  CD68; LOW QUALITY PROTEIN: macrosialin [KO:K06501]
114215048  CD63; CD63 antigen [KO:K06497]
114206787  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
114204957  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
114205907  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
114202290  CTNS; cystinosin isoform X1 [KO:K12386]
114204570  SLC17A5; sialin isoform X1 [KO:K12301]
114200184  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
114225792  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
114216189  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
114217091  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
114205882  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
114201761  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
114200396  ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656]
114209951  CD164; sialomucin core protein 24 [KO:K06546]
114217473  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
114207881  SORT1; sortilin isoform X1 [KO:K12388]
114214496  CLN3; battenin isoform X1 [KO:K12389]
114211491  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
114208291  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
114224811  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
114207749  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
114222949  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
114215593  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
114219947  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
114209355  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
114221633  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
114199991  clathrin light chain A-like isoform X1 [KO:K04644]
114213453  CLTA; clathrin light chain A [KO:K04644]
114208632  CLTB; clathrin light chain B [KO:K04645]
114202622  CLTCL1; clathrin heavy chain 2 [KO:K04646]
114213763  CLTC; clathrin heavy chain 1 [KO:K04646]
114200441  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
114217875  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
114225161  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
114196380  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
114197629  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
114200437  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
114214447  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
114210752  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
114226161  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
114217575  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
114198123  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
114224861  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
114214161  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
114200495  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
114223266  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
114206385  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
114207855  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
114214315  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
114217958  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
114216251  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
114218397  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
114198801  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
114200870  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
114219830  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
eju00511  Other glycan degradation
eju00531  Glycosaminoglycan degradation
eju04130  SNARE interactions in vesicular transport
eju04140  Autophagy - animal
eju04144  Endocytosis
KO pathway
ko04142   
LinkDB

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