KEGG   PATHWAY: els00564
Entry
els00564                    Pathway                                
Name
Glycerophospholipid metabolism - Esox lucius (northern pike)
Class
Metabolism; Lipid metabolism
Pathway map
els00564  Glycerophospholipid metabolism
els00564

Module
els_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:els00564]
els_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:els00564]
els_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:els00564]
Other DBs
GO: 0006650
Organism
Esox lucius (northern pike) [GN:els]
Gene
105005625  pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
105005694  [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105006231  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105007465  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105007573  [KO:K05929] [EC:2.1.1.103]
105007674  [KO:K01080] [EC:3.1.3.4]
105007996  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105008111  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105008260  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
105008366  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
105008442  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
105008741  [KO:K01047] [EC:3.1.1.4]
105008767  [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105009072  etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
105009076  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105009941  chat; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
105010646  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105010946  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105011590  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
105011785  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
105012034  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
105012078  pla2g6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
105012289  pnpla6; neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
105012400  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105013038  [KO:K00967] [EC:2.7.7.14]
105013079  [KO:K01080] [EC:3.1.3.4]
105013229  [KO:K01047] [EC:3.1.1.4]
105013313  phospho1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
105013508  taz; tafazzin [KO:K13511] [EC:2.3.1.-]
105013905  [KO:K13644] [EC:2.7.8.1 2.7.8.2]
105014091  [KO:K01080] [EC:3.1.3.4]
105014210  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105014247  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
105014316  [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105014360  [KO:K00981] [EC:2.7.7.41]
105014401  [KO:K14676] [EC:3.1.1.5]
105014410  [KO:K13506] [EC:2.3.1.15]
105014571  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
105014719  gpat3; glycerol-3-phosphate acyltransferase 3 isoform X2 [KO:K13506] [EC:2.3.1.15]
105014841  [KO:K14676] [EC:3.1.1.5]
105014880  [KO:K13506] [EC:2.3.1.15]
105014959  [KO:K01047] [EC:3.1.1.4]
105015134  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
105015263  [KO:K13509] [EC:2.3.1.51]
105015338  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
105015520  lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
105015650  pld4; phospholipase D4 isoform X2 [KO:K16860] [EC:3.1.4.4]
105015833  [KO:K15728] [EC:3.1.3.4]
105015879  [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105016301  [KO:K00901] [EC:2.7.1.107]
105016431  pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
105016610  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105016698  gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
105016745  [KO:K15728] [EC:3.1.3.4]
105016824  [KO:K13644] [EC:2.7.8.1 2.7.8.2]
105017052  [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105017091  [KO:K00901] [EC:2.7.1.107]
105017514  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
105017719  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
105017985  [KO:K00649] [EC:2.3.1.42]
105018465  [KO:K00894] [EC:2.7.1.82]
105018521  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
105018523  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
105018666  [KO:K00901] [EC:2.7.1.107]
105018765  [KO:K08729] [EC:2.7.8.-]
105019003  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
105019335  lpin2; phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
105019397  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
105019628  pcyt1b; choline-phosphate cytidylyltransferase B isoform X4 [KO:K00968] [EC:2.7.7.15]
105019669  [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105019720  [KO:K00111] [EC:1.1.5.3]
105019794  [KO:K01115] [EC:3.1.4.4]
105019864  [KO:K01080] [EC:3.1.3.4]
105020129  [KO:K01080] [EC:3.1.3.4]
105020329  [KO:K01049] [EC:3.1.1.7]
105020985  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105020992  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105021135  pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
105021319  pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
105021349  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
105021451  [KO:K01047] [EC:3.1.1.4]
105021553  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
105021897  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
105021916  dgkh; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
105022017  [KO:K01115] [EC:3.1.4.4]
105022084  [KO:K00006] [EC:1.1.1.8]
105022193  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105022307  dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
105023010  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
105023064  pld3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
105023459  lpcat2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105023466  [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105023484  gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
105023918  [KO:K01115] [EC:3.1.4.4]
105024807  plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105025454  etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
105025516  [KO:K01047] [EC:3.1.1.4]
105025667  [KO:K00901] [EC:2.7.1.107]
105026090  [KO:K01047] [EC:3.1.1.4]
105026319  [KO:K00006] [EC:1.1.1.8]
105026582  mboat2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105026605  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
105026681  plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105026712  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105027050  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105027324  dgkz; diacylglycerol kinase zeta isoform X3 [KO:K00901] [EC:2.7.1.107]
105027647  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
105027695  [KO:K00968] [EC:2.7.7.15]
105027919  lypla2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
105028228  [KO:K00901] [EC:2.7.1.107]
105028246  lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
105028737  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105028802  [KO:K16342] [EC:3.1.1.4]
105029083  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105029450  [KO:K00629] [EC:2.3.1.15]
105029552  samd8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
105029822  dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
105029903  dgkq; diacylglycerol kinase theta isoform X2 [KO:K00901] [EC:2.7.1.107]
105030102  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
105030153  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
105030197  [KO:K15728] [EC:3.1.3.4]
105030275  [KO:K08729] [EC:2.7.8.-]
105030431  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
105030554  [KO:K06124] [EC:3.1.3.75]
105030834  [KO:K00650] [EC:2.3.1.43]
105031137  [KO:K01047] [EC:3.1.1.4]
105031661  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
els00010  Glycolysis / Gluconeogenesis
els00260  Glycine, serine and threonine metabolism
els00561  Glycerolipid metabolism
els00562  Inositol phosphate metabolism
els00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
els00565  Ether lipid metabolism
els00620  Pyruvate metabolism
KO pathway
ko00564   

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