KEGG   PATHWAY: enf00260
Entry
enf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacter sp. FY-07
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
enf00260  Glycine, serine and threonine metabolism
enf00260

Module
enf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:enf00260]
enf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:enf00260]
enf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:enf00260]
enf_M00621  Glycine cleavage system [PATH:enf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacter sp. FY-07 [GN:enf]
Gene
AKI40_3066  aspartate kinase III [KO:K00928] [EC:2.7.2.4]
AKI40_4683  Lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
AKI40_4265  thrA; Aspartokinase/homoserine dehydrogenase, threonine-sensitive [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AKI40_4842  Bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AKI40_0375  Aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]
AKI40_4264  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
AKI40_4263  Threonine synthase [KO:K01733] [EC:4.2.3.1]
AKI40_2360  L-allo-threonine aldolase, PLP-dependent [KO:K01620] [EC:4.1.2.48]
AKI40_1317  glyA; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
AKI40_2560  Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AKI40_0178  tkrA; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AKI40_4056  garK; Glycerate kinase I [KO:K00865] [EC:2.7.1.165]
AKI40_0635  garK; Glycerate kinase I [KO:K00865] [EC:2.7.1.165]
AKI40_2201  gpmA; Phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
AKI40_4275  putative phosphoglycerate mutase gpmB [KO:K15634] [EC:5.4.2.11]
AKI40_0137  gpmI; Phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AKI40_3071  serA; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AKI40_0834  serA; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AKI40_2392  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AKI40_4282  serB; 3-phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
AKI40_2982  oxidoreductase, short chain dehydrogenase/reductase family, putative [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AKI40_0132  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
AKI40_0133  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AKI40_0844  Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AKI40_0842  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
AKI40_4164  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AKI40_0843  gcvH; Glycine cleavage system H protein [KO:K02437]
AKI40_1283  pssA; Phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
AKI40_0899  Cysteine synthase [KO:K01697] [EC:4.2.1.22]
AKI40_0898  Cystathionine gamma-synthase, PLP-dependent [KO:K01758] [EC:4.4.1.1]
AKI40_4067  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
AKI40_3527  L-serine ammonia-lyase 1 [KO:K01752] [EC:4.3.1.17]
AKI40_4814  Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
AKI40_0017  D-serine dehydratase 1 [KO:K01753] [EC:4.3.1.18]
AKI40_0917  Aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
AKI40_3332  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AKI40_3331  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AKI40_3067  Diaminobutyrate aminotransferase apoenzyme [KO:K00836] [EC:2.6.1.76]
AKI40_3068  Diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
enf00010  Glycolysis / Gluconeogenesis
enf00020  Citrate cycle (TCA cycle)
enf00230  Purine metabolism
enf00250  Alanine, aspartate and glutamate metabolism
enf00270  Cysteine and methionine metabolism
enf00290  Valine, leucine and isoleucine biosynthesis
enf00300  Lysine biosynthesis
enf00330  Arginine and proline metabolism
enf00460  Cyanoamino acid metabolism
enf00470  D-Amino acid metabolism
enf00564  Glycerophospholipid metabolism
enf00600  Sphingolipid metabolism
enf00620  Pyruvate metabolism
enf00630  Glyoxylate and dicarboxylate metabolism
enf00640  Propanoate metabolism
enf00680  Methane metabolism
enf00860  Porphyrin metabolism
enf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system