KEGG   PATHWAY: fpg04142
Entry
fpg04142                    Pathway                                
Name
Lysosome - Falco peregrinus (peregrine falcon)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
fpg04142  Lysosome
fpg04142

Other DBs
GO: 0005764
Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
101910519  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
101910790  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
101910990  ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
101911022  HYAL3; hyaluronoglucosaminidase 3 [KO:K01197] [EC:3.2.1.35]
101911100  AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
101911146  CLTA; clathrin light chain A [KO:K04644]
101911219  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
101911258  AP1S2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394]
101911328  PSAP; prosaposin [KO:K12382]
101911470  AP3D1; adaptor related protein complex 3 delta 1 subunit [KO:K12396]
101911503  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
101911722  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
101911765  CTNS; cystinosin, lysosomal cystine transporter [KO:K12386]
101911932  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
101911999  [KO:K01052] [EC:3.1.1.13]
101912135  FUCA2; fucosidase, alpha-L- 2, plasma [KO:K01206] [EC:3.2.1.51]
101912292  [KO:K01365] [EC:3.4.22.15]
101912342  ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
101912371  IDUA; iduronidase, alpha-L- [KO:K01217] [EC:3.2.1.76]
101912460  CTSA; cathepsin A [KO:K13289] [EC:3.4.16.5]
101912640  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
101912791  HEXA; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
101912794  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
101912894  GGA2; golgi associated, gamma adaptin ear containing, ARF binding protein 2 [KO:K12404]
101912963  AP1M2; adaptor related protein complex 1 mu 2 subunit [KO:K12393]
101913058  LITAF; lipopolysaccharide induced TNF factor [KO:K19363]
101913075  GM2A; GM2 ganglioside activator [KO:K12383]
101913187  TLDC1; TBC/LysM-associated domain containing 1 [KO:K27947]
101913190  CLTCL1; clathrin heavy chain like 1 [KO:K04646]
101913509  AP1M1; adaptor related protein complex 1 mu 1 subunit [KO:K12393]
101913788  DMXL2; Dmx like 2 [KO:K24155]
101913862  AP3M1; adaptor related protein complex 3 mu 1 subunit [KO:K12398]
101913873  ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
101914164  SLC11A1; solute carrier family 11 member 1 [KO:K12347]
101914337  GALC; galactosylceramidase [KO:K01202] [EC:3.2.1.46]
101914468  CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
101914508  AP3S1; adaptor related protein complex 3 sigma 1 subunit [KO:K12399]
101914561  AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
101914720  GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3 [KO:K12404]
101914762  [KO:K01052] [EC:3.1.1.13]
101914771  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101915138  SLC11A2; solute carrier family 11 member 2 [KO:K21398]
101915149  GALNS; galactosamine (N-acetyl)-6-sulfatase [KO:K01132] [EC:3.1.6.4]
101915151  ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
101915196  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
101915305  ABCA2; ATP binding cassette subfamily A member 2 [KO:K05642]
101915379  AP3B1; adaptor related protein complex 3 beta 1 subunit [KO:K12397]
101915435  ABCB9; ATP binding cassette subfamily B member 9 [KO:K05656]
101915563  LAMP3; lysosomal associated membrane protein 3 [KO:K06562]
101915707  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
101916028  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
101916176  AP1B1; adaptor related protein complex 1 beta 1 subunit [KO:K12392]
101916501  AGA; aspartylglucosaminidase [KO:K01444] [EC:3.5.1.26]
101916508  CLTB; clathrin light chain B [KO:K04645]
101916745  GGA1; golgi associated, gamma adaptin ear containing, ARF binding protein 1 [KO:K12404]
101916767  ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
101917300  ASAH1; N-acylsphingosine amidohydrolase 1 [KO:K12348] [EC:3.5.1.23]
101917386  ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
101917494  IGF2R; insulin like growth factor 2 receptor [KO:K06564]
101917516  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101917581  NCOA7; nuclear receptor coactivator 7 [KO:K25442]
101917610  HEXB; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
101917739  DMXL1; Dmx like 1 [KO:K24155]
101917741  LAPTM5; lysosomal protein transmembrane 5 [KO:K12387]
101917778  CD164; CD164 molecule [KO:K06546]
101917930  DNASE2B; deoxyribonuclease 2 beta [KO:K01158] [EC:3.1.22.1]
101917991  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
101918499  CLN5; ceroid-lipofuscinosis, neuronal 5 [KO:K12390]
101918561  [KO:K01201] [EC:3.2.1.45]
101918651  GAA; glucosidase alpha, acid [KO:K12316] [EC:3.2.1.20]
101918722  CTSC; cathepsin C [KO:K01275] [EC:3.4.14.1]
101918825  SGSH; N-sulfoglucosamine sulfohydrolase [KO:K01565] [EC:3.10.1.1]
101918931  SCARB2; scavenger receptor class B member 2 [KO:K12384]
101919114  SPAM1; sperm adhesion molecule 1 [KO:K01197] [EC:3.2.1.35]
101919160  GLB1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]
101919163  WDR7; WD repeat domain 7 [KO:K24738]
101919242  HYAL1; hyaluronoglucosaminidase 1 [KO:K01197] [EC:3.2.1.35]
101919257  SORT1; sortilin 1 [KO:K12388]
101919279  HYAL4; hyaluronoglucosaminidase 4 [KO:K01197] [EC:3.2.1.35]
101919327  TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
101919413  HYAL2; hyaluronoglucosaminidase 2 [KO:K01197] [EC:3.2.1.35]
101919451  [KO:K01197] [EC:3.2.1.35]
101919609  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
101919682  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
101919735  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
101919797  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
101919831  MANBA; mannosidase beta [KO:K01192] [EC:3.2.1.25]
101919900  GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
101919930  NAGLU; N-acetyl-alpha-glucosaminidase [KO:K01205] [EC:3.2.1.50]
101919973  [KO:K03662]
101920194  AP4E1; adaptor related protein complex 4 epsilon 1 subunit [KO:K12400]
101920453  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
101920511  LAPTM4B; lysosomal protein transmembrane 4 beta [KO:K12387]
101920551  SLC17A5; solute carrier family 17 member 5 [KO:K12301]
101920597  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101920699  FUCA1; fucosidase, alpha-L- 1, tissue [KO:K01206] [EC:3.2.1.51]
101920745  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
101920803  TPP1; tripeptidyl peptidase 1 [KO:K01279] [EC:3.4.14.9]
101920893  SUMF1; sulfatase modifying factor 1 [KO:K13444] [EC:1.8.3.7]
101920963  GNS; glucosamine (N-acetyl)-6-sulfatase [KO:K01137] [EC:3.1.6.14]
101921111  ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
101921468  AP3S2; adaptor related protein complex 3 sigma 2 subunit [KO:K12399]
101921511  [KO:K01201] [EC:3.2.1.45]
101921655  SMPD1; sphingomyelin phosphodiesterase 1 [KO:K12350] [EC:3.1.4.12]
101921677  [KO:K01201] [EC:3.2.1.45]
101921895  AP3M2; adaptor related protein complex 3 mu 2 subunit [KO:K12398]
101921963  GNPTAB; N-acetylglucosamine-1-phosphate transferase alpha and beta subunits [KO:K08239] [EC:2.7.8.17]
101921975  LAPTM4A; lysosomal protein transmembrane 4 alpha [KO:K12387]
101921980  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
101922144  CTSH; cathepsin H [KO:K01366] [EC:3.4.22.16]
101922304  MCOLN1; mucolipin-1 [KO:K04992]
101922362  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
101922485  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
101922637  AP4B1; adaptor related protein complex 4 beta 1 subunit [KO:K12401]
101922758  AP3B2; adaptor related protein complex 3 beta 2 subunit [KO:K12397]
101922957  MFSD8; major facilitator superfamily domain containing 8 [KO:K12307]
101922966  AP4S1; adaptor related protein complex 4 sigma 1 subunit [KO:K12403]
101923255  [KO:K01382] [EC:3.4.23.34]
101923480  GNPTG; N-acetylglucosamine-1-phosphate transferase gamma subunit [KO:K10087]
101923498  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
101923544  [KO:K01319] [EC:3.4.21.20]
101924021  [KO:K12316] [EC:3.2.1.20]
101924531  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
101924773  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
101924992  CLTC; clathrin heavy chain [KO:K04646]
101925019  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
fpg00511  Other glycan degradation
fpg00531  Glycosaminoglycan degradation
fpg04130  SNARE interactions in vesicular transport
fpg04140  Autophagy - animal
fpg04144  Endocytosis
KO pathway
ko04142   

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