Entry Name Wnt signaling pathway - Gallus gallus (chicken)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Gallus gallus (chicken) [GN:
gga ]
Gene 101748851 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
107055136 SMAD4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501 ]
374080 TLE4Z1; transducin-like enhancer protein 4 [KO:K04497 ]
374174 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
374175 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
378890 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
395113 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
395132 SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
395230 TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490 ]
395237 SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166 ]
395396 WNT3A; protein Wnt-3a isoform 1 precursor [KO:K00312 ]
395479 PPARD; peroxisome proliferator-activated receptor delta [KO:K04504 ]
395545 FRZB; secreted frizzled-related protein 3 precursor [KO:K25481 ]
395546 SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176 ]
395870 RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
395871 RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
415568 TLE3; transducin-like enhancer protein 3 isoform X2 [KO:K04497 ]
415603 MCC; colorectal mutant cancer protein isoform X2 [KO:K26734 ]
415607 APC; adenomatous polyposis coli protein isoform X3 [KO:K02085 ]
415711 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
415729 NKD1; protein naked cuticle homolog 1 isoform X2 [KO:K03213 ]
416181 FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362 ]
416319 SKP1; S-phase kinase-associated protein 1 [KO:K03094 ]
416730 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
417561 SERPINF1; pigment epithelium-derived factor precursor [KO:K19614 ]
418044 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
419097 LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
419346 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332 ]
419416 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
420322 WISP1; WNT1-inducible-signaling pathway protein 1 precursor [KO:K22471 ]
420732 SFRP4; secreted frizzled-related protein 4 isoform X1 [KO:K02185 ]
420815 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X9 [KO:K04446 ]
421173 LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399 ]
421422 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X3 [KO:K04512 ]
422531 DKK2; dickkopf-related protein 2 isoform X2 [KO:K02165 ]
422688 CAMK2D; calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515 ] [EC:2.7.11.17 ]
423014 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
423114 LRP5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068 ]
423532 DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
423737 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
423838 SFRP5; secreted frizzled-related protein 5 precursor [KO:K02222 ]
423854 BTRC; F-box/WD repeat-containing protein 1A isoform X4 [KO:K03362 ]
424542 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X7 [KO:K04345 ] [EC:2.7.11.11 ]
424949 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X6 [KO:K02353 ]
426045 TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508 ]
426284 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
427450 TLE1; transducin-like enhancer protein 1 isoform X3 [KO:K04497 ]
427687 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
427867 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308 ]
427937 WNT7B; protein Wnt-7b isoform 1 precursor [KO:K00572 ]
428413 BAMBI; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162 ]
428605 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309 ]
428973 LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471 ]
429363 APC2; adenomatous polyposis coli protein 2 [KO:K02085 ]
769516 ROR2; tyrosine-protein kinase transmembrane receptor ROR2 precursor [KO:K05123 ] [EC:2.7.10.1 ]
771427 PRICKLE2; prickle-like protein 2 isoform X2 [KO:K04511 ]
771460 CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
