KEGG   PATHWAY: gga04010
Entry
gga04010                    Pathway                                
Name
MAPK signaling pathway - Gallus gallus (chicken)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gga04010  MAPK signaling pathway
gga04010

Other DBs
GO: 0000165
Organism
Gallus gallus (chicken) [GN:gga]
Gene
100194427  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100499189  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
100857380  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100857832  DDIT3; uncharacterized protein DDIT3 [KO:K04452]
100857880  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100857910  ARTN; artemin isoform X1 [KO:K25415]
100858193  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
100858338  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100858386  [KO:K04464] [EC:2.7.11.24]
100858422  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100858676  MAX; protein max isoform X2 [KO:K04453]
100858946  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100859132  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X4 [KO:K12326]
100859853  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100873157  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
101748851  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101749229  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101750513  [KO:K04423] [EC:2.7.11.25]
101750560  [KO:K04456] [EC:2.7.11.1]
107049790  [KO:K04344]
107049885  [KO:K05866] [EC:3.1.3.48]
107050029  [KO:K04864]
107050393  [KO:K05462]
107050551  [KO:K04431] [EC:2.7.12.2]
107050634  CACNG7; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
107050884  [KO:K04435]
107054794  CRK; adapter molecule crk [KO:K04438]
107055370  JUND; transcription factor jun-D [KO:K04449]
107055388  [KO:K04408] [EC:2.7.11.1]
373924  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
373929  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
373953  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
374094  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
374100  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
374128  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
374169  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
374192  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
374196  PDGFA; platelet-derived growth factor subunit A preproprotein [KO:K04359]
374259  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform a [KO:K04865]
374272  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
378783  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
378804  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
378890  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
378917  FGF9; fibroblast growth factor 9 [KO:K04358]
386572  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
386574  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
386579  RPS6KA1L; ribosomal protein S6 kinase 2 alpha [KO:K04373] [EC:2.7.11.1]
395097  IGF2; insulin-like growth factor II precursor [KO:K13769]
395113  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
395129  ANGPT1; angiopoietin-1 precursor [KO:K05465]
395149  MRAS; ras-related protein M-Ras [KO:K07831]
395196  IL1B; interleukin-1 beta [KO:K04519]
395255  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
395261  FLNA; filamin-A [KO:K04437]
395274  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
395323  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
395378  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
395394  FGF19; fibroblast growth factor 19 precursor [KO:K22603]
395432  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
395453  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
395469  PDGFC; platelet-derived growth factor C precursor [KO:K05450]
395476  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
395499  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
395509  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
395569  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
395603  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
395610  ANGPT2; angiopoietin-2 [KO:K05466]
395642  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
395671  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
395693  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
395727  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
395742  FLT4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
395831  EFNA2; ephrin-A2 precursor [KO:K05462]
395853  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
395870  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
395871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
395889  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
395891  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
395895  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
395909  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
395917  CDC42; cell division control protein 42 homolog precursor [KO:K04393]
395928  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
395941  HGF; hepatocyte growth factor precursor [KO:K05460]
395983  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
395985  CATSPER2; voltage-dependent L-type calcium channel subunit alpha-1S isoform 1 [KO:K04857]
396027  RELA; transcription factor p65 [KO:K04735]
396028  KITLG; kit ligand isoform 1 precursor [KO:K05461]
396033  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
396057  STMN1; stathmin [KO:K04381]
396085  NF1; neurofibromin isoform X4 [KO:K08052]
396094  FGF1; fibroblast growth factor 1 precursor [KO:K18496]
396100  EFNA5; ephrin-A5 precursor [KO:K05462]
396103  SRF; serum response factor [KO:K04378]
396107  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
396134  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
396145  INS-IGF2; insulin preproinsulin precursor [KO:K04526]
396157  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
396186  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
396227  HSPB1; heat shock protein beta-1 [KO:K04455]
396229  HRAS; GTPase HRas precursor [KO:K02833]
396239  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
396245  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
396259  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
396267  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
396313  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
396337  NTRK1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
396349  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
396394  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
396399  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
396406  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
396413  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
396438  TGFB3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377]
396466  NGF; beta-nerve growth factor precursor [KO:K02582]
396481  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
396494  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
396512  FOS; proto-oncogene c-Fos [KO:K04379]
396515  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
396516  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
408035  EGF; pro-epidermal growth factor precursor [KO:K04357]
408036  EREG; proepiregulin precursor [KO:K09784]
414743  TGFA; protransforming growth factor alpha precursor [KO:K08774]
415439  FGF7; fibroblast growth factor 7 [KO:K04358]
415549  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
415557  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
415578  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
415700  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
415711  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
415891  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
415917  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
415996  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860]
416496  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
416526  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
416567  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
416939  CRKL; crk-like protein [KO:K04438]
417287  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
417312  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
417428  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
417429  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
417430  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
417445  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
417583  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
417669  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
417739  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
417796  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
417840  RAP1B; ras-related protein Rap-1b precursor [KO:K07836]
418014  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
418044  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
418090  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
418207  KRAS; GTPase KRas [KO:K07827]
418325  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
418605  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
418714  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
418978  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
419083  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
419187  STK4; serine/threonine-protein kinase 4 [KO:K04411]
419832  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
419847  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
419867  RAP1A; ras-related protein Rap-1A [KO:K04353]
419885  NRAS; GTPase NRas precursor [KO:K07828]
419954  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
419964  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
420133  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
420332  MYC; myc proto-oncogene protein [KO:K04377]
420419  MAPKKK3L; mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
420420  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
420479  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
420815  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X9 [KO:K04446]
421183  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
421340  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
421352  TGFB2; transforming growth factor beta-2 precursor [KO:K13376]
421404  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
421460  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
421497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
421570  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
421579  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
421622  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
421688  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
421808  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
422273  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
422316  VEGFRKDRL; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
422330  FGF16; fibroblast growth factor 16 [KO:K04358]
422380  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
422418  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
422573  VEGFC; vascular endothelial growth factor C [KO:K05449]
422592  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
423062  RRAS2; ras-related protein R-Ras2 [KO:K07830]
423085  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
423163  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
423202  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
423226  PLA2G4EL7; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
423227  PLA2G4EL6; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
423229  PLA2G4EL1; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
423290  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
423408  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
423525  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
423572  SOS2; son of sevenless homolog 2 [KO:K03099]
423669  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
423778  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
423890  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
424149  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
424225  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
424261  AMHR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
424412  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
424542  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X7 [KO:K04345] [EC:2.7.11.11]
424673  JUN; transcription factor AP-1 [KO:K04448]
424782  RASA2; ras GTPase-activating protein 2 [KO:K08053]
424860  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
424876  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
424908  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
424997  MECOM; MDS1 and EVI1 complex locus protein isoform X6 [KO:K04462] [EC:2.1.1.367]
425210  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
425375  STK3; serine/threonine-protein kinase 3 [KO:K04412]
425527  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
425792  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
425805  NGFR; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
425965  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X7 [KO:K04406] [EC:2.7.11.1]
426130  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
426737  MAPT; microtubule-associated protein tau [KO:K04380]
426792  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
426986  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
427144  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
427327  RASA1; ras GTPase-activating protein 1 [KO:K04352]
427368  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
427900  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
427909  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X2 [KO:K04867]
428099  NTF3; neurotrophin-3 isoform 2 preproprotein [KO:K04356]
428104  FGF23; fibroblast growth factor 23 [KO:K22428]
428340  NRTN; neurturin [KO:K25414]
428420  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
428586  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
428752  AREG; amphiregulin precursor [KO:K09782]
428779  FGF20; fibroblast growth factor 20 [KO:K04358]
428857  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
428870  PLA2G4EL3; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
428871  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
429064  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
429269  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
429929  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
430150  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
431192  SOS1; son of sevenless homolog 1 [KO:K03099]
431336  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
693245  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
693255  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
768444  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein [KO:K04858]
768907  FGF6; fibroblast growth factor 6 [KO:K04358]
769007  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
769385  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
769763  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
769924  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
770435  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
770457  FGF5; fibroblast growth factor 5 isoform X2 [KO:K04358]
770488  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
770905  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
771145  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
771550  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
771552  PLA2G4EL5; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
771560  PLA2G4EL4; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
771574  PLA2G4EL2; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
771763  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
771832  PGF; placenta growth factor [KO:K16859]
771961  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
771985  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
772239  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
777366  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
gga04070  Phosphatidylinositol signaling system
gga04110  Cell cycle
gga04115  p53 signaling pathway
gga04210  Apoptosis
gga04310  Wnt signaling pathway
KO pathway
ko04010   

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