KEGG   PATHWAY: gga04115
Entry
gga04115                    Pathway                                
Name
p53 signaling pathway - Gallus gallus (chicken)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
gga04115  p53 signaling pathway
gga04115

Organism
Gallus gallus (chicken) [GN:gga]
Gene
100529062  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100858796  [KO:K20394]
100859755  ADGRB1; adhesion G protein-coupled receptor B1 isoform X3 [KO:K04596]
100859853  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101749643  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
101751545  CDKN1AL; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
373904  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B precursor [KO:K04722]
373954  BCL2L1; bcl-2-like protein 1 [KO:K04570]
373987  THBS1; thrombospondin-1 precursor [KO:K16857]
374047  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
374076  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
374260  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
378914  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
395236  BID; BH3-interacting domain death agonist [KO:K04726]
395274  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
395284  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
395401  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
395476  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
395609  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
396252  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
396282  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
396341  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
408037  SFN; 14-3-3 protein sigma [KO:K06644]
415400  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
415948  SHISA5; protein shisa-5 [KO:K10135]
416161  CCNG1; cyclin-G1 [KO:K10145]
416552  TSC2; tuberin isoform X1 [KO:K07207]
417644  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
417926  APAF1; apoptotic protease-activating factor 1 isoform X3 [KO:K02084]
418090  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
419382  TP73; tumor protein p73 isoform X4 [KO:K10148]
419711  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
419823  MDM4; protein Mdm4 isoform X1 [KO:K10127]
419928  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
419946  RPRML; protein reprimo [KO:K10128]
420231  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
420253  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
420558  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
420624  CYCS; cytochrome c [KO:K08738]
420790  IGFBP3; insulin-like growth factor-binding protein 3 precursor [KO:K10138]
420900  SERPINB5; serpin B5 [KO:K10139]
421682  PERP2; p53 apoptosis effector related to PMP-22 [KO:K10136]
421683  PERP1; PERP, TP53 apoptosis effector [KO:K10136]
421766  SESN1; sestrin-1 isoform X1 [KO:K10141]
421936  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
421977  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
422211  SESN2; sestrin-3 [KO:K10141]
422512  CCNG2; cyclin-G2 [KO:K10146]
423172  CD82; CD82 antigen [KO:K06509]
423185  DDB2; DNA damage-binding protein 2 [KO:K10140]
423493  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
423675  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
423720  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
424275  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
424777  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
425204  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
425428  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
426117  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
426464  LRRC27; LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130]
426970  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
428089  SESN3; sestrin-3 [KO:K10141]
429072  RFWD2; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
429929  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
693255  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
693266  CASP18; initiator caspase [KO:K04398] [EC:3.4.22.61]
768913  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
770077  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
770613  GORAB; RAB6-interacting golgin isoform X2 [KO:K19748]
771726  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
gga04110  Cell cycle
gga04210  Apoptosis
gga04218  Cellular senescence
KO pathway
ko04115   

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