KEGG   PATHWAY: glu00260
Entry
glu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Glutamicibacter sp. ZJUTW
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
glu00260  Glycine, serine and threonine metabolism
glu00260

Module
glu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:glu00260]
glu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:glu00260]
glu_M00555  Betaine biosynthesis, choline => betaine [PATH:glu00260]
glu_M00621  Glycine cleavage system [PATH:glu00260]
glu_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:glu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Glutamicibacter sp. ZJUTW [GN:glu]
Gene
F0M17_01515  aspartate kinase [KO:K00928] [EC:2.7.2.4]
F0M17_11745  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
F0M17_06245  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
F0M17_06255  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
F0M17_06250  threonine synthase [KO:K01733] [EC:4.2.3.1]
F0M17_10035  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
F0M17_12850  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
F0M17_13365  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
F0M17_05120  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
F0M17_04630  glycerate kinase [KO:K00865] [EC:2.7.1.165]
F0M17_15975  glycerate kinase [KO:K00865] [EC:2.7.1.165]
F0M17_02705  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
F0M17_07135  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
F0M17_02935  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
F0M17_08000  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
F0M17_04470  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
F0M17_04465  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
F0M17_12785  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
F0M17_12865  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
F0M17_12860  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
F0M17_10260  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
F0M17_12855  gcvH; glycine cleavage system protein GcvH [KO:K02437]
F0M17_09555  FAD-dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
F0M17_13405  M24 family metallopeptidase [KO:K08688] [EC:3.5.3.3]
F0M17_03745  choline oxidase [KO:K17755] [EC:1.1.3.17]
F0M17_12805  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
F0M17_03740  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
F0M17_15510  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
F0M17_15515  iron-sulfur cluster-binding domain-containing protein [KO:K21832] [EC:1.14.13.251]
F0M17_15520  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
F0M17_14590  FAD-dependent oxidoreductase [KO:K00301] [EC:1.5.3.1]
F0M17_13350  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
F0M17_13360  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
F0M17_13345  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
F0M17_13355  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
F0M17_11825  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
F0M17_12845  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
F0M17_03855  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
F0M17_09830  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
F0M17_09835  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
F0M17_04735  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
F0M17_16010  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
glu00010  Glycolysis / Gluconeogenesis
glu00020  Citrate cycle (TCA cycle)
glu00230  Purine metabolism
glu00250  Alanine, aspartate and glutamate metabolism
glu00270  Cysteine and methionine metabolism
glu00290  Valine, leucine and isoleucine biosynthesis
glu00300  Lysine biosynthesis
glu00330  Arginine and proline metabolism
glu00460  Cyanoamino acid metabolism
glu00470  D-Amino acid metabolism
glu00564  Glycerophospholipid metabolism
glu00600  Sphingolipid metabolism
glu00620  Pyruvate metabolism
glu00630  Glyoxylate and dicarboxylate metabolism
glu00640  Propanoate metabolism
glu00680  Methane metabolism
glu00860  Porphyrin metabolism
glu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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