KEGG ORTHOLOGY: K04684

ORTHOLOGY: K04684

Entry

K04684                      KO

Symbol

SP1

Name

transcription factor Sp1

Pathway

map01522

Endocrine resistance

map04137

Mitophagy - animal

map04350

TGF-beta signaling pathway

map04915

Estrogen signaling pathway

map04927

Cortisol synthesis and secretion

map04928

Parathyroid hormone synthesis, secretion and action

map04934

Cushing syndrome

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05224

Breast cancer

map05231

Choline metabolism in cancer

map05415

Diabetic cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04684  SP1; transcription factor Sp1
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04684  SP1; transcription factor Sp1
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04684  SP1; transcription factor Sp1
   04928 Parathyroid hormone synthesis, secretion and action
    K04684  SP1; transcription factor Sp1
   04927 Cortisol synthesis and secretion
    K04684  SP1; transcription factor Sp1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04684  SP1; transcription factor Sp1
   05202 Transcriptional misregulation in cancer
    K04684  SP1; transcription factor Sp1
   05231 Choline metabolism in cancer
    K04684  SP1; transcription factor Sp1
  09162 Cancer: specific types
   05224 Breast cancer
    K04684  SP1; transcription factor Sp1
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04684  SP1; transcription factor Sp1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04684  SP1; transcription factor Sp1
   05017 Spinocerebellar ataxia
    K04684  SP1; transcription factor Sp1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04684  SP1; transcription factor Sp1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04684  SP1; transcription factor Sp1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04684  SP1; transcription factor Sp1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04684  SP1; transcription factor Sp1
   03029 Mitochondrial biogenesis
    K04684  SP1; transcription factor Sp1
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys2His2 SP/KLF family and related proteins
    K04684  SP1; transcription factor Sp1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K04684  SP1; transcription factor Sp1

Genes

HSA:

6667(SP1)

PTR:	451939(SP1)

PPS:	100985203(SP1)

GGO:	129525695(SP1)

PON:	100440745(SP1)

PPYG:

129009680(SP1)

NLE:	100585963(SP1)

HMH:	116481003(SP1)

SSYN:

129466125(SP1)

MCC:	702710(SP1)

MCF:	102115996(SP1)

MTHB:

126931105

MNI:	105474275(SP1)

CSAB:

103238395(SP1)

CATY:

105580268(SP1)

PANU:

116268873(SP1)

TGE:	112634626(SP1)

MLEU:

105554908(SP1)

RRO:	104670595(SP1)

RBB:	108521535(SP1)

TFN:	117090035(SP1)

PTEH:

111541933

CANG:

105503673(SP1)

CJC:	100407824(SP1)

SBQ:	101048381(SP1)

CIMI:

108284876(SP1)

ANAN:

105715866(SP1)

CSYR:

103260226

MMUR:

105870777(SP1)

LCAT:

123639764(SP1)

PCOQ:

105818043(SP1)

OGA:	100953042(SP1)

MMU:	20683(Sp1)

MCAL:

110310111(Sp1)

MPAH:

110334488(Sp1)

RNO:	24790(Sp1)

MCOC:

116080468(Sp1)

ANU:	117718542(Sp1)

MUN:	110552322(Sp1)

CGE:	100767199(Sp1)

MAUA:

101842935(Sp1)

PROB:

127226146(Sp1)

PLEU:

114696625(Sp1)

MORG:

121444220 121459388

MFOT:

126491183

AAMP:

119823260(Sp1)

NGI:	103738561(Sp1)

HGL:	101697506(Sp1)

CPOC:

100726500(Sp1)

CCAN:

109684073(Sp1)

DORD:

105997935(Sp1)

DSP:	122124412(Sp1)

PLOP:

125364008(Sp1)

NCAR:

124962851 124983225

MMMA:

107148811(Sp1)

OCU:

100351317

OPI:	101533630(SP1)

TUP:	102473003(SP1)

GVR:	103592813(SP1)

CFA:	486507(SP1)

CLUD:

112667184(SP1)

VVP:	112921180(SP1)

VLG:	121479904(SP1)

NPO:	129517345(SP1)

AML:	100474983(SP1)

UMR:	103675530(SP1)

UAR:	123794698(SP1)

ELK:

111157856

LLV:

125106436

MPUF:

101686835(SP1)

MNP:	132019731(SP1)

MLK:	131838694(SP1)

NVS:	122892412(SP1)

ORO:	101367562(SP1)

EJU:	114225869(SP1)

ZCA:	113921297(SP1)

MLX:	118008792(SP1)

NSU:	110577393(SP1)

LWW:	102750952(SP1)

FCA:	101100227(SP1)

PYU:	121038490(SP1)

PCOO:

112867279(SP1)

PBG:	122473480(SP1)

PVIV:

125169758(SP1)

LRUF:

124502539

PTG:	102955984(SP1)

PPAD:

109249199(SP1)

PUC:

125919123

AJU:

106983094

HHV:	120247236(SP1)

BTA:	540741(SP1)

BOM:	102282294(SP1)

BIU:	109559035(SP1)

BBUB:

102392142(SP1)

BBIS:

105001581(SP1)

CHX:	100860911(SP1)

OAS:	101104139(SP1)

BTAX:

128047386(SP1)

ODA:	120858300(SP1)

CCAD:

122427132(SP1)

MBEZ:

129535764(SP1)

SSC:	396575(SP1)

CFR:	102520683(SP1)

CBAI:

105076285(SP1)

CDK:	105094564(SP1)

VPC:	102540803(SP1)

BACU:

103010578(SP1)

BMUS:

118901868(SP1)

OOR:	101284508(SP1)

DLE:	111173942(SP1)

PCAD:

102973166(SP1)

PSIU:

116760263(SP1)

NASI:

112394040(SP1)

ECB:	100629527(SP1)

EPZ:	103559402(SP1)

EAI:	106835289(SP1)

MYB:	102256096(SP1)

MYD:	102752526(SP1) 102753263

MMYO:

118650196(SP1)

MLF:	102419937(SP1)

MDT:	132227671(SP1)

PKL:	118728518(SP1)

EFUS:

103285347(SP1)

MNA:	107528307(SP1)

DRO:	112318338(SP1)

AJM:	119043517(SP1)

PDIC:

114513239(SP1)

PHAS:

123812402(SP1)

MMF:	118623453(SP1)

PPAM:

129084812(SP1)

HAI:	109391846(SP1)

RFQ:	117028359(SP1)

PALE:

102894100(SP1)

PGIG:

120602177(SP1)

PVP:	105302655(SP1)

RAY:	107509855(SP1)

MJV:	108394782(SP1)

TOD:	119247989(SP1)

SARA:

101550205(SP1)

SETR:

126022125(SP1)

LAV:	100662543(SP1)

TMU:

101349790

ETF:	101656971(SP1)

DNM:	101441960(SP1)

GAS:	123250447(SP1)

SHR:	100930024(SP1)

AFZ:

127539187

PCW:	110194006(SP1)

TVP:	118849909(SP1)

OAA:	114814764(SP1)

GGA:	395303(SP1)

PCOC:

116234959(SP1)

MGP:	100539328(SP1)

CJO:	107306967(SP1)

NMEL:

110390879(SP1)

ACYG:

106049581(SP1)

CATA:

118261637(SP1)

TGU:	115491349(SP1)

LSR:	110480534(SP1)

SCAN:

103825226(SP1)

PMOA:

120501829(SP1)

OTC:	121335576(SP1)

PRUF:

121356081(SP1)

FAB:	101818755(SP1)

OMA:	130265886(SP1)

PHI:	102112711(SP1)

PMAJ:

107198749(SP1)

CCAE:

111940460(SP1)

CBRC:

103620426(SP1)

ETL:	114072464(SP1)

ZLE:	135459071(SP1)

SVG:	106863620(SP1)

MMEA:

130586745(SP1)

HRT:	120764517(SP1)

SATI:

136372758(SP1)

FPG:	101921378(SP1)

FCH:	102046473(SP1)

CCRI:

104158086(SP1)

SHAB:

115618625(SP1)

ACUN:

113490686(SP1)

ACHC:

115350863(SP1)

HALD:

104320978(SP1)

HLE:	104830278(SP1)

AGEN:

126046439

CSTI:

104555928(SP1)

LDI:	104339751(SP1)

DPUB:

104309612(SP1)

EGZ:	104124794(SP1)

NNI:	104017530(SP1)

PADL:

103925632(SP1)

AFOR:

103898173(SP1)

FGA:	104074723(SP1)

GSTE:

104262017

CLV:	102091713(SP1)

MUI:	104541243(SP1)

PGUU:

104465949

PLET:

104619218(SP1)

CUCA:

104055651(SP1)

TEO:	104374672(SP1)

BREG:

104631946(SP1)

CPEA:

104397440(SP1)

RTD:	128903816(SP1)

AAM:	106487505(SP1)

AROW:

112961692(SP1)

NPD:	112952281(SP1)

DNE:	112996339(SP1)

SCAM:

104145526(SP1)

ASN:	102370562(SP1)

AMJ:	102557884(SP1)

CPOO:

109323220(SP1)

PSS:	102450768(SP1)

CMY:	102943070(SP1)

CCAY:

125627418(SP1)

DCC:	119845757(SP1)

CPIC:

101949432(SP1)

TST:	117888449(SP1)

CABI:

116828475(SP1)

MRV:	120391068(SP1)

ACS:	100553756(sp1)

ASAO:

132767660(SP1)

PVT:	110074383(SP1)

SUND:

121921686(SP1)

PBI:	103052107(SP1)

PMUR:

107291239(SP1)

CTIG:

120309973(SP1)

TSR:	106552859(SP1)

PGUT:

117662667(SP1)

APRI:

131189583(SP1)

PTEX:

113445573(SP1)

NSS:	113418432(SP1)

VKO:	123029773(SP1)

PMUA:

114593046(SP1)

PRAF:

128406725(SP1)

ZVI:	118077160(SP1)

HCG:	128342787(SP1)

GJA:	107119663(SP1)

EMC:	129346042(SP1)

XLA:	108709905(sp1.S) 431939(sp1.L)

XTR:	394744(sp1)

NPR:	108786826(SP1)

RTEM:

120929328(SP1)

BBUF:

120996097(SP1)

BGAR:

122930637(SP1)

MUO:	115466821(SP1)

GSH:	117357473(SP1)

DRE:	324109(sp1)

SRX:	107742020(sp1) 107748519

SANH:

107663256 107690773

SGH:

107575074

CCAR:

109055633 109082561

CAUA:

113068116(sp1)

CGIB:

127967798

PTET:

122332822(sp1)

LROH:

127173298(sp1)

OMC:	131549245(sp1)

PPRM:

120483641(sp1)

RKG:	130086272(sp1)

MAMB:

125256370(sp1)

CIDE:

127522541

CERY:

137021797(sp1)

MASI:

127426577 127428316

TROS:

130549521(sp1)

TDW:	130410424(sp1)

MANU:

129427237(sp1)

IPU:

108254785

IFU:	128624771(sp1)

PHYP:

113524457(sp1)

SMEO:

124402225(sp1)

TFD:	113643964(sp1)

TVC:	132838110(sp1)

TRN:	134301990(sp1)

AMEX:

103027197(sp1)

CMAO:

118799824(sp1)

EEE:	113581441(sp1)

CHAR:

105900246(sp1)

TRU:	101071233(sp1)

TFS:	130523796(sp1)

TNG:	GSTEN00013587G001

LCO:	104919961(sp1)

NCC:

104962038

TBEN:

117489446(sp1)

CGOB:

115008146(sp1)

PGEO:

117446848(sp1)

GACU:

117534246(sp1)

EMAC:

134883063(sp1)

ELY:	117256362(sp1)

EFO:	125898073(sp1)

PLEP:

121957297(sp1)

SLUC:

116051354(sp1)

ECRA:

117943581(sp1)

ESP:	116688600(sp1)

PFLV:

114554650(sp1)

GAT:	120835455(sp1)

PPUG:

119229581(sp1)

AFB:	129106444(sp1)

CLUM:

117731360(sp1)

PSWI:

130208812(sp1)

MSAM:

119885812(sp1)

SCHU:

122863200(sp1)

CUD:	121507071(sp1)

ALAT:

119020987(sp1)

MZE:	101477446(sp1)

ONL:	100690316(sp1)

OAU:	116320762(sp1)

OLA:	101161549(sp1)

OML:	112144742(sp1)

CSAI:

133448301(sp1)

XMA:	102236306(sp1)

XCO:	114134954(sp1)

XHE:	116710631(sp1)

PRET:

103464412(sp1)

PFOR:

103135891(sp1)

PLAI:

106956674(sp1)

PMEI:

106928483(sp1)

GAF:	122833402(sp1)

PPRL:

129355044(sp1)

CVG:	107103259(sp1)

CTUL:

119789679(sp1)

GMU:	124857569(sp1)

NFU:	107385320(sp1)

KMR:	108231465(sp1)

ALIM:

106514730(sp1)

NWH:	119411843(sp1)

AOCE:

111583780(sp1)

MCEP:

125006195(sp1)

CSEM:

103386384(sp1)

POV:	109635527(sp1)

SSEN:

122768811(sp1)

HHIP:

117761907(sp1)

HSP:	118105456(sp1)

PPLT:

128448542(sp1)

SMAU:

118309364(sp1)

LCF:

108884839

SDU:	111224016(sp1)

SLAL:

111670201(sp1)

XGL:	120807114(sp1)

HCQ:	109510616(sp1)

SSCV:

125977882

SBIA:

133507592(sp1)

PEE:	133408879(sp1)

PTAO:

133483239(sp1)

BPEC:

110171184(sp1)

MALB:

109959387(sp1)

BSPL:

114855393(sp1)

SJO:	128355965(sp1)

SASA:

106566174(sp1)

STRU:

115207322(sp1)

OTW:	112235852(sp1)

OMY:	110494799(sp1)

OGO:	124002635(sp1)

ONE:	115117400(sp1)

OKI:	109899785(sp1)

OKE:	118374681(sp1)

SALP:

112069701(sp1)

SNH:	120057948(sp1)

CCLU:

121574801(sp1)

ELS:	105031425(sp1)

SFM:	108928412(sp1)

PKI:	111835274(sp1)

AANG:

118208449 118211736(sp1)

LOC:

102682631

PSPA:

121308931(sp1)

ARUT:

117401144 117966968

PSEX:

120524944

LCM:	102366212(SP1)

CMK:

103190683

LERI:

129694994

TPRE:

106650949

MBR:	MONBRDRAFT_37070(CI)

» show all

Reference

PMID:21798247

Authors

Infantino V, Convertini P, Iacobazzi F, Pisano I, Scarcia P, Iacobazzi V

Title

Identification of a novel Sp1 splice variant as a strong transcriptional activator.

Journal

Biochem Biophys Res Commun 412:86-91 (2011)
DOI:10.1016/j.bbrc.2011.07.047

Sequence

[hsa:6667]

Reference

PMID:10391891

Authors

Ding H, Benotmane AM, Suske G, Collen D, Belayew A

Title

Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

Journal

J Biol Chem 274:19573-80 (1999)
DOI:10.1074/jbc.274.28.19573

Sequence

[hsa:6667]

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