KEGG   Homo sapiens (human): 5366
Entry
5366              CDS       T01001                                 
Symbol
PMAIP1, APR, NOXA
Name
(RefSeq) phorbol-12-myristate-13-acetate-induced protein 1
  KO
K10131  phorbol-12-myristate-13-acetate-induced protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05210  Colorectal cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
  Element
N00098  Intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    5366 (PMAIP1)
   04215 Apoptosis - multiple species
    5366 (PMAIP1)
   04115 p53 signaling pathway
    5366 (PMAIP1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5366 (PMAIP1)
   05203 Viral carcinogenesis
    5366 (PMAIP1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5366 (PMAIP1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    5366 (PMAIP1)
SSDB
Motif
Pfam: PMAIP1
Other DBs
NCBI-GeneID: 5366
NCBI-ProteinID: NP_066950
OMIM: 604959
HGNC: 9108
Ensembl: ENSG00000141682
UniProt: Q13794 A0A0S2Z490
Structure
LinkDB
Position
18:59899996..59904305
AA seq 54 aa
MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLNLISKLFCSGT
NT seq 165 nt   +upstreamnt  +downstreamnt
atgcctgggaagaaggcgcgcaagaacgctcaaccgagccccgcgcgggctccagcagag
ctggaagtcgagtgtgctactcaactcaggagatttggagacaaactgaacttccggcag
aaacttctgaatctgatatccaaactcttctgctcaggaacctga

KEGG   Homo sapiens (human): 27113
Entry
27113             CDS       T01001                                 
Symbol
BBC3, JFY-1, JFY1, PUMA
Name
(RefSeq) BCL2 binding component 3
  KO
K10132  Bcl-2-binding component 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04390  Hippo signaling pathway
hsa05016  Huntington disease
hsa05162  Measles
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
  Element
N00098  Intrinsic apoptotic pathway
N00695  MV V to p73-mediated transcription
N00982  Mutation-caused aberrant Htt to p53-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    27113 (BBC3)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    27113 (BBC3)
   04215 Apoptosis - multiple species
    27113 (BBC3)
   04115 p53 signaling pathway
    27113 (BBC3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    27113 (BBC3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    27113 (BBC3)
  09172 Infectious disease: viral
   05162 Measles
    27113 (BBC3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    27113 (BBC3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    27113 (BBC3)
SSDB
Other DBs
NCBI-GeneID: 27113
NCBI-ProteinID: NP_001120712
OMIM: 605854
HGNC: 17868
Ensembl: ENSG00000105327
UniProt: Q96PG8 Q9BXH1
Structure
LinkDB
Position
19:complement(47220824..47232860)
AA seq 261 aa
MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLP
ARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAP
RPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGG
RPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDS
GGRPLPPPDTLASAGDFLCTM
NT seq 786 nt   +upstreamnt  +downstreamnt
atgaaatttggcatggggtctgcccaggcatgtccatgccaggtgcccagggctgcttcc
acgacgtgggtcccctgccagatttgtggccccagggagcgccatggcccgcgcacgcca
ggagggcagctccccggagcccgtagagggcctggcccgcgacggcccgcgccccttccc
gctcggccgcctggtgccctcggcagtgtcctgcggcctctgcgagcccggcctggctgc
cgcccccgccgcccccaccctgctgcccgctgcctacctctgcgcccccaccgccccacc
cgccgtcaccgccgccctggggggttcccgctggcctgggggtccccgcagccggccccg
aggcccgcgcccggacggtcctcagccctcgctctcgctggcggagcagcacctggagtc
gcccgtgcccagcgccccgggggctctggcgggcggtcccacccaggcggccccgggagt
ccgcggggaggaggaacagtgggcccgggagatcggggcccagctgcggcggatggcgga
cgacctcaacgcacagtacgagcggcggagacaagaggagcagcagcggcaccgcccctc
accctggagggtcctgtacaatctcatcatgggactcctgcccttacccaggggccacag
agcccccgagatggagcccaattaggtgcctgcacccgcccggtggacgtcagggactcg
gggggcaggcccctcccacctcctgacaccctggccagcgcgggggactttctctgcacc
atgtag

KEGG   Homo sapiens (human): 572
Entry
572               CDS       T01001                                 
Symbol
BAD, BBC2, BCL2L8
Name
(RefSeq) BCL2 associated agonist of cell death
  KO
K02158  Bcl-2-antagonist of cell death
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04140  Autophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05165  Human papillomavirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05225  Hepatocellular carcinoma
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00098  Intrinsic apoptotic pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00384  HPV E6 to intrinsic apoptotic pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00452  HIV Nef to intrinsic apoptotic pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00585  HSV US3 to intrinsic apoptotic pathway
N01348  Nicotine/NNK to PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    572 (BAD)
   04014 Ras signaling pathway
    572 (BAD)
   04370 VEGF signaling pathway
    572 (BAD)
   04024 cAMP signaling pathway
    572 (BAD)
   04022 cGMP-PKG signaling pathway
    572 (BAD)
   04151 PI3K-Akt signaling pathway
    572 (BAD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    572 (BAD)
  09143 Cell growth and death
   04210 Apoptosis
    572 (BAD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    572 (BAD)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    572 (BAD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    572 (BAD)
   04919 Thyroid hormone signaling pathway
    572 (BAD)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    572 (BAD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    572 (BAD)
   05207 Chemical carcinogenesis - receptor activation
    572 (BAD)
   05208 Chemical carcinogenesis - reactive oxygen species
    572 (BAD)
   05203 Viral carcinogenesis
    572 (BAD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    572 (BAD)
   05212 Pancreatic cancer
    572 (BAD)
   05225 Hepatocellular carcinoma
    572 (BAD)
   05221 Acute myeloid leukemia
    572 (BAD)
   05220 Chronic myeloid leukemia
    572 (BAD)
   05218 Melanoma
    572 (BAD)
   05211 Renal cell carcinoma
    572 (BAD)
   05215 Prostate cancer
    572 (BAD)
   05213 Endometrial cancer
    572 (BAD)
   05223 Non-small cell lung cancer
    572 (BAD)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    572 (BAD)
   05161 Hepatitis B
    572 (BAD)
   05160 Hepatitis C
    572 (BAD)
   05162 Measles
    572 (BAD)
   05168 Herpes simplex virus 1 infection
    572 (BAD)
   05165 Human papillomavirus infection
    572 (BAD)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    572 (BAD)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    572 (BAD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    572 (BAD)
   05014 Amyotrophic lateral sclerosis
    572 (BAD)
   05020 Prion disease
    572 (BAD)
   05022 Pathways of neurodegeneration - multiple diseases
    572 (BAD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    572 (BAD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    572 (BAD)
   01524 Platinum drug resistance
    572 (BAD)
   01522 Endocrine resistance
    572 (BAD)
SSDB
Motif
Pfam: Bcl-2_BAD Bclx_interact
Other DBs
NCBI-GeneID: 572
NCBI-ProteinID: NP_004313
OMIM: 603167
HGNC: 936
Ensembl: ENSG00000002330
UniProt: Q92934
Structure
LinkDB
Position
11:complement(64269828..64284704)
AA seq 168 aa
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
NT seq 507 nt   +upstreamnt  +downstreamnt
atgttccagatcccagagtttgagccgagtgagcaggaagactccagctctgcagagagg
ggcctgggccccagccccgcaggggacgggccctcaggctccggcaagcatcatcgccag
gccccaggcctcctgtgggacgccagtcaccagcaggagcagccaaccagcagcagccat
catggaggcgctggggctgtggagatccggagtcgccacagctcctaccccgcggggacg
gaggacgacgaagggatgggggaggagcccagcccctttcggggccgctcgcgctcggcg
ccccccaacctctgggcagcacagcgctatggccgcgagctccggaggatgagtgacgag
tttgtggactcctttaagaagggacttcctcgcccgaagagcgcgggcacagcaacgcag
atgcggcaaagctccagctggacgcgagtcttccagtcctggtgggatcggaacttgggc
aggggaagctccgccccctcccagtga

KEGG   Homo sapiens (human): 10018
Entry
10018             CDS       T01001                                 
Symbol
BCL2L11, BAM, BIM, BOD
Name
(RefSeq) BCL2 like 11
  KO
K16341  Bcl-2-like protein 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04068  FoxO signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04932  Non-alcoholic fatty liver disease
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
  Element
N00098  Intrinsic apoptotic pathway
N00262  EBV EBNA3C to intrinsic apoptotic pathway
N00474  EBV BHRF1 to intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    10018 (BCL2L11)
   04151 PI3K-Akt signaling pathway
    10018 (BCL2L11)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    10018 (BCL2L11)
   04215 Apoptosis - multiple species
    10018 (BCL2L11)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10018 (BCL2L11)
   05206 MicroRNAs in cancer
    10018 (BCL2L11)
  09162 Cancer: specific types
   05210 Colorectal cancer
    10018 (BCL2L11)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    10018 (BCL2L11)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    10018 (BCL2L11)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    10018 (BCL2L11)
SSDB
Motif
Pfam: Bclx_interact Bim_N Phage_blade
Other DBs
NCBI-GeneID: 10018
NCBI-ProteinID: NP_619527
OMIM: 603827
HGNC: 994
Ensembl: ENSG00000153094
UniProt: O43521
Structure
LinkDB
Position
2:111120914..111168445
AA seq 198 aa
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSP
QGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPP
CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH
NT seq 597 nt   +upstreamnt  +downstreamnt
atggcaaagcaaccttctgatgtaagttctgagtgtgaccgagaaggtagacaattgcag
cctgcggagaggcctccccagctcagacctggggcccctacctccctacagacagagcca
caaggtaatcctgaaggcaatcacggaggtgaaggggacagctgcccccacggcagccct
cagggcccgctggccccacctgccagccctggcccttttgctaccagatccccgcttttc
atctttatgagaagatcctccctgctgtctcgatcctccagtgggtatttctcttttgac
acagacaggagcccagcacccatgagttgtgacaaatcaacacaaaccccaagtcctcct
tgccaggccttcaaccactatctcagtgcaatggcttccatgaggcaggctgaacctgca
gatatgcgcccagagatatggatcgcccaagagttgcggcgtattggagacgagtttaac
gcttactatgcaaggagggtatttttgaataattaccaagcagccgaagaccacccacga
atggttatcttacgactgttacgttacattgtccgcctggtgtggagaatgcattga

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