KEGG   Homo sapiens (human): 7412
Entry
7412              CDS       T01001                                 
Symbol
VCAM1, CD106, INCAM-100
Name
(RefSeq) vascular cell adhesion molecule 1
  KO
K06527  vascular cell adhesion molecule 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04518  Integrin signaling
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06548  Integrin signaling
  Element
N01306  AngII-AT1R-NOX2 signaling pathway
N01921  Integrin alpha4beta1 signaling
N01973  Integrin alpha4beta7 signaling
N01974  Integrin alpha9beta1 signaling
N01977  Integrin alphaDbeta2 signaling
Drug target
Camobucol: D06570
Elsibucol: D06582
Succinobucol: D06648
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7412 (VCAM1)
   04668 TNF signaling pathway
    7412 (VCAM1)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecule (CAM) interaction
    7412 (VCAM1)
   04518 Integrin signaling
    7412 (VCAM1)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    7412 (VCAM1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05144 Malaria
    7412 (VCAM1)
   05143 African trypanosomiasis
    7412 (VCAM1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7412 (VCAM1)
   05418 Fluid shear stress and atherosclerosis
    7412 (VCAM1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    7412 (VCAM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    7412 (VCAM1)
   04090 CD molecules [BR:hsa04090]
    7412 (VCAM1)
   04091 Lectins [BR:hsa04091]
    7412 (VCAM1)
Cell adhesion molecules [BR:hsa04515]
 Immunoglobulin superfamily
  VCAM
   7412 (VCAM1)
CD molecules [BR:hsa04090]
 Proteins
  7412 (VCAM1)
Lectins [BR:hsa04091]
 I-type lectins (Siglecs)
  7412 (VCAM1)
SSDB
Motif
Pfam: I-set Ig_3 C2-set ig Ig_2 V-set C2-set_2 ICAM_N ICAM1_3_5_D2 Ig_6 Ig_4 C2-set_3 Ig_5 Ig_PDGFR_d4 Adhes-Ig_like
Other DBs
NCBI-GeneID: 7412
NCBI-ProteinID: NP_001069
OMIM: 192225
HGNC: 12663
Ensembl: ENSG00000162692
UniProt: P19320
Structure
LinkDB
Position
1:100719742..100739045
AA seq 739 aa
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV
NT seq 2220 nt   +upstreamnt  +downstreamnt
atgcctgggaagatggtcgtgatccttggagcctcaaatatactttggataatgtttgca
gcttctcaagcttttaaaatcgagaccaccccagaatctagatatcttgctcagattggt
gactccgtctcattgacttgcagcaccacaggctgtgagtccccatttttctcttggaga
acccagatagatagtccactgaatgggaaggtgacgaatgaggggaccacatctacgctg
acaatgaatcctgttagttttgggaacgaacactcttacctgtgcacagcaacttgtgaa
tctaggaaattggaaaaaggaatccaggtggagatctactcttttcctaaggatccagag
attcatttgagtggccctctggaggctgggaagccgatcacagtcaagtgttcagttgct
gatgtatacccatttgacaggctggagatagacttactgaaaggagatcatctcatgaag
agtcaggaatttctggaggatgcagacaggaagtccctggaaaccaagagtttggaagta
acctttactcctgtcattgaggatattggaaaagttcttgtttgccgagctaaattacac
attgatgaaatggattctgtgcccacagtaaggcaggctgtaaaagaattgcaagtctac
atatcacccaagaatacagttatttctgtgaatccatccacaaagctgcaagaaggtggc
tctgtgaccatgacctgttccagcgagggtctaccagctccagagattttctggagtaag
aaattagataatgggaatctacagcacctttctggaaatgcaactctcaccttaattgct
atgaggatggaagattctggaatttatgtgtgtgaaggagttaatttgattgggaaaaac
agaaaagaggtggaattaattgttcaagagaaaccatttactgttgagatctcccctgga
ccccggattgctgctcagattggagactcagtcatgttgacatgtagtgtcatgggctgt
gaatccccatctttctcctggagaacccagatagacagccctctgagcgggaaggtgagg
agtgaggggaccaattccacgctgaccctgagccctgtgagttttgagaacgaacactct
tatctgtgcacagtgacttgtggacataagaaactggaaaagggaatccaggtggagctc
tactcattccctagagatccagaaatcgagatgagtggtggcctcgtgaatgggagctct
gtcactgtaagctgcaaggttcctagcgtgtacccccttgaccggctggagattgaatta
cttaagggggagactattctggagaatatagagtttttggaggatacggatatgaaatct
ctagagaacaaaagtttggaaatgaccttcatccctaccattgaagatactggaaaagct
cttgtttgtcaggctaagttacatattgatgacatggaattcgaacccaaacaaaggcag
agtacgcaaacactttatgtcaatgttgcccccagagatacaaccgtcttggtcagccct
tcctccatcctggaggaaggcagttctgtgaatatgacatgcttgagccagggctttcct
gctccgaaaatcctgtggagcaggcagctccctaacggggagctacagcctctttctgag
aatgcaactctcaccttaatttctacaaaaatggaagattctggggtttatttatgtgaa
ggaattaaccaggctggaagaagcagaaaggaagtggaattaattatccaagttactcca
aaagacataaaacttacagcttttccttctgagagtgtcaaagaaggagacactgtcatc
atctcttgtacatgtggaaatgttccagaaacatggataatcctgaagaaaaaagcggag
acaggagacacagtactaaaatctatagatggcgcctataccatccgaaaggcccagttg
aaggatgcgggagtatatgaatgtgaatctaaaaacaaagttggctcacaattaagaagt
ttaacacttgatgttcaaggaagagaaaacaacaaagactatttttctcctgagcttctc
gtgctctattttgcatcctccttaataatacctgccattggaatgataatttactttgca
agaaaagccaacatgaaggggtcatatagtcttgtagaagcacagaagtcaaaagtgtag

KEGG   Homo sapiens (human): 3386
Entry
3386              CDS       T01001                                 
Symbol
ICAM4, CD242, LW
Name
(RefSeq) intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  KO
K06581  intercellular adhesion molecule 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04518  Integrin signaling
Network
nt06548  Integrin signaling
  Element
N01921  Integrin alpha4beta1 signaling
N01975  Integrin alphaLbeta2 signaling
N01976  Integrin alphaMbeta2 signaling
N01998  Integrin alphaXbeta2 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    3386 (ICAM4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    3386 (ICAM4)
   04090 CD molecules [BR:hsa04090]
    3386 (ICAM4)
Cell adhesion molecules [BR:hsa04515]
 Immunoglobulin superfamily
  ICAM
   3386 (ICAM4)
CD molecules [BR:hsa04090]
 Proteins
  3386 (ICAM4)
SSDB
Motif
Pfam: ICAM_N ICAM1_3_5_D2
Other DBs
NCBI-GeneID: 3386
NCBI-ProteinID: NP_001535
OMIM: 614088
HGNC: 5347
Ensembl: ENSG00000105371
UniProt: Q14773
LinkDB
Position
19:10286955..10288520
AA seq 271 aa
MGSLFPLSLLFFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWVRMSPEFVAVQ
PGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRAWSSLAHCLVTCAGK
TRWATSRITAYKPPHSVILEPPVLKGRKYTLRCHVTQVFPVGYLVVTLRHGSRVIYSESL
ERFTGLDLANVTLTYEFAAGPRDFWQPVICHARLNLDGLVVRNSSAPITLMLAWSPAPTA
LASGSIAALVGILLTVGAAYLCKCLAMKSQA
NT seq 816 nt   +upstreamnt  +downstreamnt
atggggtctctgttccctctgtcgctgctgttttttttggcggccgcctacccgggagtt
gggagcgcgctgggacgccggactaagcgggcgcaaagccccaagggtagccctctcgcg
ccctccgggacctcagtgcccttctgggtgcgcatgagcccggagttcgtggctgtgcag
ccggggaagtcagtgcagctcaattgcagcaacagctgtccccagccgcagaattccagc
ctccgcaccccgctgcggcaaggcaagacgctcagagggccgggttgggtgtcttaccag
ctgctcgacgtgagggcctggagctccctcgcgcactgcctcgtgacctgcgcaggaaaa
acacgctgggccacctccaggatcaccgcctacaaaccgccccacagcgtgattttggag
cctccggtcttaaagggcaggaaatacactttgcgctgccacgtgacgcaggtgttcccg
gtgggctacttggtggtgaccctgaggcatggaagccgggtcatctattccgaaagcctg
gagcgcttcaccggcctggatctggccaacgtgaccttgacctacgagtttgctgctgga
ccccgcgacttctggcagcccgtgatctgccacgcgcgcctcaatctcgacggcctggtg
gtccgcaacagctcggcacccattacactgatgctcgcttggagccccgcgcccacagct
ttggcctccggttccatcgctgcccttgtagggatcctcctcactgtgggcgctgcgtac
ctatgcaagtgcctagctatgaagtcccaggcgtaa

KEGG   Homo sapiens (human): 8174
Entry
8174              CDS       T01001                                 
Symbol
MADCAM1, MACAM1
Name
(RefSeq) mucosal vascular addressin cell adhesion molecule 1
  KO
K06779  mucosal vascular addressin cell adhesion molecule 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04518  Integrin signaling
hsa04672  Intestinal immune network for IgA production
Network
nt06548  Integrin signaling
  Element
N01921  Integrin alpha4beta1 signaling
N01973  Integrin alpha4beta7 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecule (CAM) interaction
    8174 (MADCAM1)
   04518 Integrin signaling
    8174 (MADCAM1)
 09150 Organismal Systems
  09151 Immune system
   04672 Intestinal immune network for IgA production
    8174 (MADCAM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules [BR:hsa04515]
    8174 (MADCAM1)
Cell adhesion molecules [BR:hsa04515]
 Immunoglobulin superfamily
  Other
   8174 (MADCAM1)
SSDB
Motif
Pfam: Adhes-Ig_like ig ICAM_N
Other DBs
NCBI-GeneID: 8174
NCBI-ProteinID: NP_570116
OMIM: 102670
HGNC: 6765
Ensembl: ENSG00000099866
UniProt: Q13477
Structure
LinkDB
Position
19:496486..505343
AA seq 382 aa
MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGASVQW
RGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQLLVYAFPDQLTV
SPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGDED
VLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHRQAIPVLHSPTSPEPPDTTSPES
PDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGP
TQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLLALPTYHLWKRCRHLAEDDTHPPASLR
LLPQVSAWAGLRGTGQVGISPS
NT seq 1149 nt   +upstreamnt  +downstreamnt
atggatttcggactggccctcctgctggcggggcttctggggctcctcctcggccagtcc
ctccaggtgaagcccctgcaggtggagcccccggagccggtggtggccgtggccttgggc
gcctcgcgccagctcacctgccgcctggcctgcgcggaccgcggggcctcggtgcagtgg
cggggcctggacaccagcctgggcgcggtgcagtcggacacgggccgcagcgtcctcacc
gtgcgcaacgcctcgctgtcggcggccgggacccgcgtgtgcgtgggctcctgcgggggc
cgcaccttccagcacaccgtgcagctccttgtgtacgccttcccggaccagctgaccgtc
tccccagcagccctggtgcctggtgacccggaggtggcctgtacggcccacaaagtcacg
cccgtggaccccaacgcgctctccttctccctgctcgtcgggggccaggaactggagggg
gcgcaagccctgggcccggaggtgcaggaggaggaggaggagccccagggggacgaggac
gtgctgttcagggtgacagagcgctggcggctgccgcccctggggacccctgtcccgccc
gccctctactgccaggccacgatgaggctgcctggcttggagctcagccaccgccaggcc
atccccgtcctgcacagcccgacctccccggagcctcccgacaccacctccccggagtct
cccgacaccacctccccggagtctcccgacaccacctcccaggagcctcccgacaccacc
tccccggagcctcccgacaagacctccccggagcccgccccccagcagggctccacacac
acccccaggagcccaggctccaccaggactcgccgccctgagatctcccaggctgggccc
acgcagggagaagtgatcccaacaggctcgtccaaacctgcgggtgaccagctgcccgcg
gctctgtggaccagcagtgcggtgctgggactgctgctcctggccttgcccacctatcac
ctctggaaacgctgccggcacctggctgaggacgacacccacccaccagcttctctgagg
cttctgccccaggtgtcggcctgggctgggttaagggggaccggccaggtcgggatcagc
ccctcctga

KEGG   Homo sapiens (human): 2335
Entry
2335              CDS       T01001                                 
Symbol
FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF
Name
(RefSeq) fibronectin 1
  KO
K05717  fibronectin 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04810  Regulation of actin cytoskeleton
hsa04820  Cytoskeleton in muscle cells
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05100  Bacterial invasion of epithelial cells
hsa05135  Yersinia infection
hsa05146  Amoebiasis
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05222  Small cell lung cancer
Network
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N00393  ITGA/B-RhoGAP-RhoA signaling pathway
N00951  ITGA/B-RHOG-RAC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01070  ITGA/B-FAK-CDC42 signaling pathway
N01072  ITGA/B-RhoGEF-RhoA signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01973  Integrin alpha4beta7 signaling
N01977  Integrin alphaDbeta2 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01981  Integrin alpha8beta1 signaling
N01982  Integrin alphaVbeta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01985  Integrin alphaVbeta6 signaling
N01986  Integrin alphaVbeta8 signaling
Disease
H01260  Glomerulopathy with fibronectin deposits
H02185  Spondylometaphyseal dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    2335 (FN1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    2335 (FN1)
   04518 Integrin signaling
    2335 (FN1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2335 (FN1)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    2335 (FN1)
   04810 Regulation of actin cytoskeleton
    2335 (FN1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2335 (FN1)
   05205 Proteoglycans in cancer
    2335 (FN1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    2335 (FN1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    2335 (FN1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    2335 (FN1)
   05100 Bacterial invasion of epithelial cells
    2335 (FN1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    2335 (FN1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    2335 (FN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2335 (FN1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2335 (FN1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2335 (FN1)
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    2335 (FN1)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    2335 (FN1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   2335 (FN1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   2335 (FN1)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 Fibronectin (FN) domain-containing proteins
  Fibronectin type I domain-containing proteins
   2335 (FN1)
SSDB
Motif
Pfam: fn3 fn1 FN3_DSCAM-DSCAML_C Pur_ac_phosph_N fn2 Fn3_Dep-1_2nd Fn3_VIN3 Fn3_Dep-1_3rd NDNF FN3_Tor_3rd Ig_RIMBP2
Other DBs
NCBI-GeneID: 2335
NCBI-ProteinID: NP_997647
OMIM: 135600
HGNC: 3778
Ensembl: ENSG00000115414
UniProt: P02751 Q6MZM7 Q9UQS6
Structure
LinkDB
Position
2:complement(215360865..215436068)
AA seq 2477 aa
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV
GYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAP
PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTP
LRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHS
RNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWD
APAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPA
SSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKT
AGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIK
IAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDM
ESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEIN
LAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETT
ITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDN
ARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVP
RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPE
ILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPI
RHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDT
SEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVT
VGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSR
WCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQ
KEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPI
ECFMPLDVQADREDSRE
NT seq 7434 nt   +upstreamnt  +downstreamnt
atgcttaggggtccggggcccgggctgctgctgctggccgtccagtgcctggggacagcg
gtgccctccacgggagcctcgaagagcaagaggcaggctcagcaaatggttcagccccag
tccccggtggctgtcagtcaaagcaagcccggttgttatgacaatggaaaacactatcag
ataaatcaacagtgggagcggacctacctaggcaatgcgttggtttgtacttgttatgga
ggaagccgaggttttaactgcgagagtaaacctgaagctgaagagacttgctttgacaag
tacactgggaacacttaccgagtgggtgacacttatgagcgtcctaaagactccatgatc
tgggactgtacctgcatcggggctgggcgagggagaataagctgtaccatcgcaaaccgc
tgccatgaagggggtcagtcctacaagattggtgacacctggaggagaccacatgagact
ggtggttacatgttagagtgtgtgtgtcttggtaatggaaaaggagaatggacctgcaag
cccatagctgagaagtgttttgatcatgctgctgggacttcctatgtggtcggagaaacg
tgggagaagccctaccaaggctggatgatggtagattgtacttgcctgggagaaggcagc
ggacgcatcacttgcacttctagaaatagatgcaacgatcaggacacaaggacatcctat
agaattggagacacctggagcaagaaggataatcgaggaaacctgctccagtgcatctgc
acaggcaacggccgaggagagtggaagtgtgagaggcacacctctgtgcagaccacatcg
agcggatctggccccttcaccgatgttcgtgcagctgtttaccaaccgcagcctcacccc
cagcctcctccctatggccactgtgtcacagacagtggtgtggtctactctgtggggatg
cagtggctgaagacacaaggaaataagcaaatgctttgcacgtgcctgggcaacggagtc
agctgccaagagacagctgtaacccagacttacggtggcaactcaaatggagagccatgt
gtcttaccattcacctacaatggcaggacgttctactcctgcaccacagaagggcgacag
gacggacatctttggtgcagcacaacttcgaattatgagcaggaccagaaatactctttc
tgcacagaccacactgttttggttcagactcgaggaggaaattccaatggtgccttgtgc
cacttccccttcctatacaacaaccacaattacactgattgcacttctgagggcagaaga
gacaacatgaagtggtgtgggaccacacagaactatgatgccgaccagaagtttgggttc
tgccccatggctgcccacgaggaaatctgcacaaccaatgaaggggtcatgtaccgcatt
ggagatcagtgggataagcagcatgacatgggtcacatgatgaggtgcacgtgtgttggg
aatggtcgtggggaatggacatgcattgcctactcgcagcttcgagatcagtgcattgtt
gatgacatcacttacaatgtgaacgacacattccacaagcgtcatgaagaggggcacatg
ctgaactgtacatgcttcggtcagggtcggggcaggtggaagtgtgatcccgtcgaccaa
tgccaggattcagagactgggacgttttatcaaattggagattcatgggagaagtatgtg
catggtgtcagataccagtgctactgctatggccgtggcattggggagtggcattgccaa
cctttacagacctatccaagctcaagtggtcctgtcgaagtatttatcactgagactccg
agtcagcccaactcccaccccatccagtggaatgcaccacagccatctcacatttccaag
tacattctcaggtggagacctaaaaattctgtaggccgttggaaggaagctaccatacca
ggccacttaaactcctacaccatcaaaggcctgaagcctggtgtggtatacgagggccag
ctcatcagcatccagcagtacggccaccaagaagtgactcgctttgacttcaccaccacc
agcaccagcacacctgtgaccagcaacaccgtgacaggagagacgactcccttttctcct
cttgtggccacttctgaatctgtgaccgaaatcacagccagtagctttgtggtctcctgg
gtctcagcttccgacaccgtgtcgggattccgggtggaatatgagctgagtgaggaggga
gatgagccacagtacctggatcttccaagcacagccacttctgtgaacatccctgacctg
cttcctggccgaaaatacattgtaaatgtctatcagatatctgaggatggggagcagagt
ttgatcctgtctacttcacaaacaacagcgcctgatgcccctcctgacacgactgtggac
caagttgatgacacctcaattgttgttcgctggagcagaccccaggctcccatcacaggg
tacagaatagtctattcgccatcagtagaaggtagcagcacagaactcaaccttcctgaa
actgcaaactccgtcaccctcagtgacttgcaacctggtgttcagtataacatcactatc
tatgctgtggaagaaaatcaagaaagtacacctgttgtcattcaacaagaaaccactggc
accccacgctcagatacagtgccctctcccagggacctgcagtttgtggaagtgacagac
gtgaaggtcaccatcatgtggacaccgcctgagagtgcagtgaccggctaccgtgtggat
gtgatccccgtcaacctgcctggcgagcacgggcagaggctgcccatcagcaggaacacc
tttgcagaagtcaccgggctgtcccctggggtcacctattacttcaaagtctttgcagtg
agccatgggagggagagcaagcctctgactgctcaacagacaaccaaactggatgctccc
actaacctccagtttgtcaatgaaactgattctactgtcctggtgagatggactccacct
cgggcccagataacaggataccgactgaccgtgggccttacccgaagaggacagcccagg
cagtacaatgtgggtccctctgtctccaagtacccactgaggaatctgcagcctgcatct
gagtacaccgtatccctcgtggccataaagggcaaccaagagagccccaaagccactgga
gtctttaccacactgcagcctgggagctctattccaccttacaacaccgaggtgactgag
accaccattgtgatcacatggacgcctgctccaagaattggttttaagctgggtgtacga
ccaagccagggaggagaggcaccacgagaagtgacttcagactcaggaagcatcgttgtg
tccggcttgactccaggagtagaatacgtctacaccatccaagtcctgagagatggacag
gaaagagatgcgccaattgtaaacaaagtggtgacaccattgtctccaccaacaaacttg
catctggaggcaaaccctgacactggagtgctcacagtctcctgggagaggagcaccacc
ccagacattactggttatagaattaccacaacccctacaaacggccagcagggaaattct
ttggaagaagtggtccatgctgatcagagctcctgcacttttgataacctgagtcccggc
ctggagtacaatgtcagtgtttacactgtcaaggatgacaaggaaagtgtccctatctct
gataccatcatcccagaggtgccccaactcactgacctaagctttgttgatataaccgat
tcaagcatcggcctgaggtggaccccgctaaactcttccaccattattgggtaccgcatc
acagtagttgcggcaggagaaggtatccctatttttgaagattttgtggactcctcagta
ggatactacacagtcacagggctggagccgggcattgactatgatatcagcgttatcact
ctcattaatggcggcgagagtgcccctactacactgacacaacaaacggctgttcctcct
cccactgacctgcgattcaccaacattggtccagacaccatgcgtgtcacctgggctcca
cccccatccattgatttaaccaacttcctggtgcgttactcacctgtgaaaaatgaggaa
gatgttgcagagttgtcaatttctccttcagacaatgcagtggtcttaacaaatctcctg
cctggtacagaatatgtagtgagtgtctccagtgtctacgaacaacatgagagcacacct
cttagaggaagacagaaaacaggtcttgattccccaactggcattgacttttctgatatt
actgccaactcttttactgtgcactggattgctcctcgagccaccatcactggctacagg
atccgccatcatcccgagcacttcagtgggagacctcgagaagatcgggtgccccactct
cggaattccatcaccctcaccaacctcactccaggcacagagtatgtggtcagcatcgtt
gctcttaatggcagagaggaaagtcccttattgattggccaacaatcaacagtttctgat
gttccgagggacctggaagttgttgctgcgacccccaccagcctactgatcagctgggat
gctcctgctgtcacagtgagatattacaggatcacttacggagagacaggaggaaatagc
cctgtccaggagttcactgtgcctgggagcaagtctacagctaccatcagcggccttaaa
cctggagttgattataccatcactgtgtatgctgtcactggccgtggagacagccccgca
agcagcaagccaatttccattaattaccgaacagaaattgacaaaccatcccagatgcaa
gtgaccgatgttcaggacaacagcattagtgtcaagtggctgccttcaagttcccctgtt
actggttacagagtaaccaccactcccaaaaatggaccaggaccaacaaaaactaaaact
gcaggtccagatcaaacagaaatgactattgaaggcttgcagcccacagtggagtatgtg
gttagtgtctatgctcagaatccaagcggagagagtcagcctctggttcagactgcagta
accaacattgatcgccctaaaggactggcattcactgatgtggatgtcgattccatcaaa
attgcttgggaaagcccacaggggcaagtttccaggtacagggtgacctactcgagccct
gaggatggaatccatgagctattccctgcacctgatggtgaagaagacactgcagagctg
caaggcctcagaccgggttctgagtacacagtcagtgtggttgccttgcacgatgatatg
gagagccagcccctgattggaacccagtccacagctattcctgcaccaactgacctgaag
ttcactcaggtcacacccacaagcctgagcgcccagtggacaccacccaatgttcagctc
actggatatcgagtgcgggtgacccccaaggagaagaccggaccaatgaaagaaatcaac
cttgctcctgacagctcatccgtggttgtatcaggacttatggtggccaccaaatatgaa
gtgagtgtctatgctcttaaggacactttgacaagcagaccagctcagggagttgtcacc
actctggagaatgtcagcccaccaagaagggctcgtgtgacagatgctactgagaccacc
atcaccattagctggagaaccaagactgagacgatcactggcttccaagttgatgccgtt
ccagccaatggccagactccaatccagagaaccatcaagccagatgtcagaagctacacc
atcacaggtttacaaccaggcactgactacaagatctacctgtacaccttgaatgacaat
gctcggagctcccctgtggtcatcgacgcctccactgccattgatgcaccatccaacctg
cgtttcctggccaccacacccaattccttgctggtatcatggcagccgccacgtgccagg
attaccggctacatcatcaagtatgagaagcctgggtctcctcccagagaagtggtccct
cggccccgccctggtgtcacagaggctactattactggcctggaaccgggaaccgaatat
acaatttatgtcattgccctgaagaataatcagaagagcgagcccctgattggaaggaaa
aagacagacgagcttccccaactggtaacccttccacaccccaatcttcatggaccagag
atcttggatgttccttccacagttcaaaagacccctttcgtcacccaccctgggtatgac
actggaaatggtattcagcttcctggcacttctggtcagcaacccagtgttgggcaacaa
atgatctttgaggaacatggttttaggcggaccacaccgcccacaacggccacccccata
aggcataggccaagaccatacccgccgaatgtaggtgaggaaatccaaattggtcacatc
cccagggaagatgtagactatcacctgtacccacacggtccgggactcaatccaaatgcc
tctacaggacaagaagctctctctcagacaaccatctcatgggccccattccaggacact
tctgagtacatcatttcatgtcatcctgttggcactgatgaagaacccttacagttcagg
gttcctggaacttctaccagtgccactctgacaggcctcaccagaggtgccacctacaac
gtcatagtggaggcactgaaagaccagcagaggcataaggttcgggaagaggttgttacc
gtgggcaactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgacccc
tacacagtttcccattatgccgttggagatgagtgggaacgaatgtctgaatcaggcttt
aaactgttgtgccagtgcttaggctttggaagtggtcatttcagatgtgattcatctaga
tggtgccatgacaatggtgtgaactacaagattggagagaagtgggaccgtcagggagaa
aatggccagatgatgagctgcacatgtcttgggaacggaaaaggagaattcaagtgtgac
cctcatgaggcaacgtgttatgatgatgggaagacataccacgtaggagaacagtggcag
aaggaatatctcggtgccatttgctcctgcacatgctttggaggccagcggggctggcgc
tgtgacaactgccgcagacctgggggtgaacccagtcccgaaggcactactggccagtcc
tacaaccagtattctcagagataccatcagagaacaaacactaatgttaattgcccaatt
gagtgcttcatgcctttagatgtacaggctgacagagaagattcccgagagtaa

KEGG   Homo sapiens (human): 6696
Entry
6696              CDS       T01001                                 
Symbol
SPP1, BNSP, BSPI, ETA-1, OPN
Name
(RefSeq) secreted phosphoprotein 1
  KO
K06250  secreted phosphoprotein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04620  Toll-like receptor signaling pathway
hsa04929  GnRH secretion
hsa05165  Human papillomavirus infection
Network
nt06548  Integrin signaling
  Element
N01921  Integrin alpha4beta1 signaling
N01973  Integrin alpha4beta7 signaling
N01974  Integrin alpha9beta1 signaling
N01980  Integrin alpha5beta1 signaling
N01982  Integrin alphaVbeta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01984  Integrin alphaVbeta5 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    6696 (SPP1)
   04151 PI3K-Akt signaling pathway
    6696 (SPP1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    6696 (SPP1)
   04518 Integrin signaling
    6696 (SPP1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    6696 (SPP1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    6696 (SPP1)
  09152 Endocrine system
   04929 GnRH secretion
    6696 (SPP1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    6696 (SPP1)
SSDB
Motif
Pfam: Osteopontin
Other DBs
NCBI-GeneID: 6696
NCBI-ProteinID: NP_001035147
OMIM: 166490
HGNC: 11255
Ensembl: ENSG00000118785
UniProt: P10451
Structure
LinkDB
Position
4:87975714..87983411
AA seq 314 aa
MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNA
VSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQS
DESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQ
YPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSH
KQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKF
RISHELDSASSEVN
NT seq 945 nt   +upstreamnt  +downstreamnt
atgagaattgcagtgatttgcttttgcctcctaggcatcacctgtgccataccagttaaa
caggctgattctggaagttctgaggaaaagcagctttacaacaaatacccagatgctgtg
gccacatggctaaaccctgacccatctcagaagcagaatctcctagccccacagaatgct
gtgtcctctgaagaaaccaatgactttaaacaagagacccttccaagtaagtccaacgaa
agccatgaccacatggatgatatggatgatgaagatgatgatgaccatgtggacagccag
gactccattgactcgaacgactctgatgatgtagatgacactgatgattctcaccagtct
gatgagtctcaccattctgatgaatctgatgaactggtcactgattttcccacggacctg
ccagcaaccgaagttttcactccagttgtccccacagtagacacatatgatggccgaggt
gatagtgtggtttatggactgaggtcaaaatctaagaagtttcgcagacctgacatccag
taccctgatgctacagacgaggacatcacctcacacatggaaagcgaggagttgaatggt
gcatacaaggccatccccgttgcccaggacctgaacgcgccttctgattgggacagccgt
gggaaggacagttatgaaacgagtcagctggatgaccagagtgctgaaacccacagccac
aagcagtccagattatataagcggaaagccaatgatgagagcaatgagcattccgatgtg
attgatagtcaggaactttccaaagtcagccgtgaattccacagccatgaatttcacagc
catgaagatatgctggttgtagaccccaaaagtaaggaagaagataaacacctgaaattt
cgtatttctcatgaattagatagtgcatcttctgaggtcaattaa

KEGG   Homo sapiens (human): 7057
Entry
7057              CDS       T01001                                 
Symbol
THBS1, THBS, THBS-1, TSP, TSP-1, TSP1
Name
(RefSeq) thrombospondin 1
  KO
K16857  thrombospondin 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04115  p53 signaling pathway
hsa04145  Phagosome
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04820  Cytoskeleton in muscle cells
hsa05144  Malaria
hsa05165  Human papillomavirus infection
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05219  Bladder cancer
Network
nt06535  Efferocytosis
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N01772  Induction of the PTGS2
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01990  Integrin alpha3beta1 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    7057 (THBS1)
   04350 TGF-beta signaling pathway
    7057 (THBS1)
   04151 PI3K-Akt signaling pathway
    7057 (THBS1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    7057 (THBS1)
   04518 Integrin signaling
    7057 (THBS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7057 (THBS1)
   04148 Efferocytosis
    7057 (THBS1)
  09143 Cell growth and death
   04115 p53 signaling pathway
    7057 (THBS1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7057 (THBS1)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    7057 (THBS1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    7057 (THBS1)
   05205 Proteoglycans in cancer
    7057 (THBS1)
  09162 Cancer: specific types
   05219 Bladder cancer
    7057 (THBS1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7057 (THBS1)
  09174 Infectious disease: parasitic
   05144 Malaria
    7057 (THBS1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7057 (THBS1)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7057 (THBS1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    7057 (THBS1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   7057 (THBS1)
SSDB
Motif
Pfam: TSP_C TSP_3 TSP_1 TSP1_spondin VWC TSP1_CFP_C VWC2L_2nd EGF_3 cEGF EGF_CA Laminin_G_3 TSP1_ADAMTS Laminin_G_2 TSP1_CCN EGF Laminin_G_1
Other DBs
NCBI-GeneID: 7057
NCBI-ProteinID: NP_003237
OMIM: 188060
HGNC: 11785
Ensembl: ENSG00000137801
UniProt: P07996
Structure
LinkDB
Position
15:39581079..39599466
AA seq 1170 aa
MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR
IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV
SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD
VPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLL
TLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRK
VTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN
ATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQT
RTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARE
TKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQI
CNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACF
NHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKN
AKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPN
LPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYN
HNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEH
NPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDN
DGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRF
QMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDD
DYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNAL
WHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD
KTYAGGRLGLFVFSQEMVFFSDLKYECRDP
NT seq 3513 nt   +upstreamnt  +downstreamnt
atggggctggcctggggactaggcgtcctgttcctgatgcatgtgtgtggcaccaaccgc
attccagagtctggcggagacaacagcgtgtttgacatctttgaactcaccggggccgcc
cgcaaggggtctgggcgccgactggtgaagggccccgacccttccagcccagctttccgc
atcgaggatgccaacctgatcccccctgtgcctgatgacaagttccaagacctggtggat
gctgtgcgggcagaaaagggtttcctccttctggcatccctgaggcagatgaagaagacc
cggggcacgctgctggccctggagcggaaagaccactctggccaggtcttcagcgtggtg
tccaatggcaaggcgggcaccctggacctcagcctgaccgtccaaggaaagcagcacgtg
gtgtctgtggaagaagctctcctggcaaccggccagtggaagagcatcaccctgtttgtg
caggaagacagggcccagctgtacatcgactgtgaaaagatggagaatgctgagttggac
gtccccatccaaagcgtcttcaccagagacctggccagcatcgccagactccgcatcgca
aaggggggcgtcaatgacaatttccagggggtgctgcagaatgtgaggtttgtctttgga
accacaccagaagacatcctcaggaacaaaggctgctccagctctaccagtgtcctcctc
acccttgacaacaacgtggtgaatggttccagccctgccatccgcactaactacattggc
cacaagacaaaggacttgcaagccatctgcggcatctcctgtgatgagctgtccagcatg
gtcctggaactcaggggcctgcgcaccattgtgaccacgctgcaggacagcatccgcaaa
gtgactgaagagaacaaagagttggccaatgagctgaggcggcctcccctatgctatcac
aacggagttcagtacagaaataacgaggaatggactgttgatagctgcactgagtgtcac
tgtcagaactcagttaccatctgcaaaaaggtgtcctgccccatcatgccctgctccaat
gccacagttcctgatggagaatgctgtcctcgctgttggcccagcgactctgcggacgat
ggctggtctccatggtccgagtggacctcctgttctacgagctgtggcaatggaattcag
cagcgcggccgctcctgcgatagcctcaacaaccgatgtgagggctcctcggtccagaca
cggacctgccacattcaggagtgtgacaagagatttaaacaggatggtggctggagccac
tggtccccgtggtcatcttgttctgtgacatgtggtgatggtgtgatcacaaggatccgg
ctctgcaactctcccagcccccagatgaacgggaaaccctgtgaaggcgaagcgcgggag
accaaagcctgcaagaaagacgcctgccccatcaatggaggctggggtccttggtcacca
tgggacatctgttctgtcacctgtggaggaggggtacagaaacgtagtcgtctctgcaac
aaccccacaccccagtttggaggcaaggactgcgttggtgatgtaacagaaaaccagatc
tgcaacaagcaggactgtccaattgatggatgcctgtccaatccctgctttgccggcgtg
aagtgtactagctaccctgatggcagctggaaatgtggtgcttgtccccctggttacagt
ggaaatggcatccagtgcacagatgttgatgagtgcaaagaagtgcctgatgcctgcttc
aaccacaatggagagcaccggtgtgagaacacggaccccggctacaactgcctgccctgc
cccccacgcttcaccggctcacagcccttcggccagggtgtcgaacatgccacggccaac
aaacaggtgtgcaagccccgtaacccctgcacggatgggacccacgactgcaacaagaac
gccaagtgcaactacctgggccactatagcgaccccatgtaccgctgcgagtgcaagcct
ggctacgctggcaatggcatcatctgcggggaggacacagacctggatggctggcccaat
gagaacctggtgtgcgtggccaatgcgacttaccactgcaaaaaggataattgccccaac
cttcccaactcagggcaggaagactatgacaaggatggaattggtgatgcctgtgatgat
gacgatgacaatgataaaattccagatgacagggacaactgtccattccattacaaccca
gctcagtatgactatgacagagatgatgtgggagaccgctgtgacaactgtccctacaac
cacaacccagatcaggcagacacagacaacaatggggaaggagacgcctgtgctgcagac
attgatggagacggtatcctcaatgaacgggacaactgccagtacgtctacaatgtggac
cagagagacactgatatggatggggttggagatcagtgtgacaattgccccttggaacac
aatccggatcagctggactctgactcagaccgcattggagatacctgtgacaacaatcag
gatattgatgaagatggccaccagaacaatctggacaactgtccctatgtgcccaatgcc
aaccaggctgaccatgacaaagatggcaagggagatgcctgtgaccacgatgatgacaac
gatggcattcctgatgacaaggacaactgcagactcgtgcccaatcccgaccagaaggac
tctgacggcgatggtcgaggtgatgcctgcaaagatgattttgaccatgacagtgtgcca
gacatcgatgacatctgtcctgagaatgttgacatcagtgagaccgatttccgccgattc
cagatgattcctctggaccccaaagggacatcccaaaatgaccctaactgggttgtacgc
catcagggtaaagaactcgtccagactgtcaactgtgatcctggactcgctgtaggttat
gatgagtttaatgctgtggacttcagtggcaccttcttcatcaacaccgaaagggacgat
gactatgctggatttgtctttggctaccagtccagcagccgcttttatgttgtgatgtgg
aagcaagtcacccagtcctactgggacaccaaccccacgagggctcagggatactcgggc
ctttctgtgaaagttgtaaactccaccacagggcctggcgagcacctgcggaacgccctg
tggcacacaggaaacacccctggccaggtgcgcaccctgtggcatgaccctcgtcacata
ggctggaaagatttcaccgcctacagatggcgtctcagccacaggccaaagacgggtttc
attagagtggtgatgtatgaagggaagaaaatcatggctgactcaggacccatctatgat
aaaacctatgctggtggtagactagggttgtttgtcttctctcaagaaatggtgttcttc
tctgacctgaaatacgaatgtagagatccctaa

KEGG   Homo sapiens (human): 7058
Entry
7058              CDS       T01001                                 
Symbol
THBS2, EDSCLL3, TSP2
Name
(RefSeq) thrombospondin 2
  KO
K04659  thrombospondin 2/3/4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04820  Cytoskeleton in muscle cells
hsa05144  Malaria
hsa05165  Human papillomavirus infection
Network
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01990  Integrin alpha3beta1 signaling
Disease
H00802  Ehlers-Danlos syndrome
H02539  Intervertebral disc disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7058 (THBS2)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    7058 (THBS2)
   04518 Integrin signaling
    7058 (THBS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7058 (THBS2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7058 (THBS2)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    7058 (THBS2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7058 (THBS2)
  09174 Infectious disease: parasitic
   05144 Malaria
    7058 (THBS2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7058 (THBS2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7058 (THBS2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7058 (THBS2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    7058 (THBS2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7058 (THBS2)
  Exosomal proteins of colorectal cancer cells
   7058 (THBS2)
  Exosomal proteins of bladder cancer cells
   7058 (THBS2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   7058 (THBS2)
SSDB
Motif
Pfam: TSP_C TSP_3 TSP_1 TSP1_spondin VWC EGF_3 VWC2L_2nd TSP1_ADAMTS TSP1_CFP_C EGF cEGF TSP1_CCN Laminin_G_2
Other DBs
NCBI-GeneID: 7058
NCBI-ProteinID: NP_003238
OMIM: 188061
HGNC: 11786
Ensembl: ENSG00000186340
UniProt: P35442
Structure
LinkDB
Position
6:complement(169215785..169253846)
AA seq 1172 aa
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF
DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP
ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY
EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN
TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC
ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI
QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG
RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER
QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH
KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC
PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP
YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL
VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR
NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR
DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN
ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI
YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI
NT seq 3519 nt   +upstreamnt  +downstreamnt
atggtctggaggctggtcctgctggctctgtgggtgtggcccagcacgcaagctggtcac
caggacaaagacacgaccttcgaccttttcagtatcagcaacatcaaccgcaagaccatt
ggcgccaagcagttccgcgggcccgaccccggcgtgccggcttaccgcttcgtgcgcttt
gactacatcccaccggtgaacgcagatgacctcagcaagatcaccaagatcatgcggcag
aaggagggcttcttcctcacggcccagctcaagcaggacggcaagtccaggggcacgctg
ttggctctggagggccccggtctctcccagaggcagttcgagatcgtctccaacggcccc
gcggacacgctggatctcacctactggattgacggcacccggcatgtggtctccctggag
gacgtcggcctggctgactcgcagtggaagaacgtcaccgtgcaggtggctggcgagacc
tacagcttgcacgtgggctgcgacctcatagacagcttcgctctggacgagcccttctac
gagcacctgcaggcggaaaagagccggatgtacgtggccaaaggctctgccagagagagt
cacttcaggggtttgcttcagaacgtccacctagtgtttgaaaactctgtggaagatatt
ctaagcaagaagggttgccagcaaggccagggagctgagatcaacgccatcagtgagaac
acagagacgctgcgcctgggtccgcatgtcaccaccgagtacgtgggccccagctcggag
aggaggcccgaggtgtgcgaacgctcgtgcgaggagctgggaaacatggtccaggagctc
tcggggctccacgtcctcgtgaaccagctcagcgagaacctcaagagagtgtcgaatgat
aaccagtttctctgggagctcattggtggccctcctaagacaaggaacatgtcagcttgc
tggcaggatggccggttctttgcggaaaatgaaacgtgggtggtggacagctgcaccacg
tgtacctgcaagaaatttaaaaccatttgccaccaaatcacctgcccgcctgcaacctgc
gccagtccatcctttgtggaaggcgaatgctgcccttcctgcctccactcggtggacggt
gaggagggctggtctccgtgggcagagtggacccagtgctccgtgacgtgtggctctggg
acccagcagagaggccggtcctgtgacgtcaccagcaacacctgcttggggccctccatc
cagacacgggcttgcagtctgagcaagtgtgacacccgcatccggcaggacggcggctgg
agccactggtcaccttggtcttcatgctctgtgacctgtggagttggcaatatcacacgc
atccgtctctgcaactccccagtgccccagatggggggcaagaattgcaaagggagtggc
cgggagaccaaagcctgccagggcgccccatgcccaatcgatggccgctggagcccctgg
tccccgtggtcggcctgcactgtcacctgtgccggtgggatccgggagcgcacccgggtc
tgcaacagccctgagcctcagtacggagggaaggcctgcgtgggggatgtgcaggagcgt
cagatgtgcaacaagaggagctgccccgtggatggctgtttatccaacccctgcttcccg
ggagcccagtgcagcagcttccccgatgggtcctggtcatgcggctcctgccctgtgggc
ttcttgggcaatggcacccactgtgaggacctggacgagtgtgccctggtccccgacatc
tgcttctccaccagcaaggtgcctcgctgtgtcaacactcagcctggcttccactgcctg
ccctgcccgccccgatacagagggaaccagcccgtcggggtcggcctggaagcagccaag
acggaaaagcaagtgtgtgagcccgaaaacccatgcaaggacaagacacacaactgccac
aagcacgcggagtgcatctacctgggccacttcagcgaccccatgtacaagtgcgagtgc
cagacaggctacgcgggcgacgggctcatctgcggggaggactcggacctggacggctgg
cccaacctcaatctggtctgcgccaccaacgccacctaccactgcatcaaggataactgc
ccccatctgccaaattctgggcaggaagactttgacaaggacgggattggcgatgcctgt
gatgatgacgatgacaatgacggtgtgaccgatgagaaggacaactgccagctcctcttc
aatccccgccaggctgactatgacaaggatgaggttggggaccgctgtgacaactgccct
tacgtgcacaaccctgcccagatcgacacagacaacaatggagagggtgacgcctgctcc
gtggacattgatggggacgatgtcttcaatgaacgagacaattgtccctacgtctacaac
actgaccagagggacacggatggtgacggtgtgggggatcactgtgacaactgccccctg
gtgcacaaccctgaccagaccgacgtggacaatgaccttgttggggaccagtgtgacaac
aacgaggacatagatgacgacggccaccagaacaaccaggacaactgcccctacatctcc
aacgccaaccaggctgaccatgacagagacggccagggcgacgcctgtgaccctgatgat
gacaacgatggcgtccccgatgacagggacaactgccggcttgtgttcaacccagaccag
gaggacttggacggtgatggacggggtgatatttgtaaagatgattttgacaatgacaac
atcccagatattgatgatgtgtgtcctgaaaacaatgccatcagtgagacagacttcagg
aacttccagatggtccccttggatcccaaagggaccacccaaattgatcccaactgggtc
attcgccatcaaggcaaggagctggttcagacagccaactcggaccccggcatcgctgta
ggttttgacgagtttgggtctgtggacttcagtggcacattctacgtaaacactgaccgg
gacgacgactatgccggcttcgtctttggttaccagtcaagcagccgcttctatgtggtg
atgtggaagcaggtgacgcagacctactgggaggaccagcccacgcgggcctatggctac
tccggcgtgtccctcaaggtggtgaactccaccacggggacgggcgagcacctgaggaac
gcgctgtggcacacggggaacacgccggggcaggtgcgaaccttatggcacgaccccagg
aacattggctggaaggactacacggcctataggtggcacctgactcacaggcccaagact
ggctacatcagagtcttagtgcatgaaggaaaacaggtcatggcagactcaggacctatc
tatgaccaaacctacgctggcgggcggctgggtctatttgtcttctctcaagaaatggtc
tatttctcagacctcaagtacgaatgcagagatatttaa

KEGG   Homo sapiens (human): 7059
Entry
7059              CDS       T01001                                 
Symbol
THBS3, TSP3
Name
(RefSeq) thrombospondin 3
  KO
K04659  thrombospondin 2/3/4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04820  Cytoskeleton in muscle cells
hsa05144  Malaria
hsa05165  Human papillomavirus infection
Network
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01990  Integrin alpha3beta1 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7059 (THBS3)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    7059 (THBS3)
   04518 Integrin signaling
    7059 (THBS3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7059 (THBS3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7059 (THBS3)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    7059 (THBS3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7059 (THBS3)
  09174 Infectious disease: parasitic
   05144 Malaria
    7059 (THBS3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7059 (THBS3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7059 (THBS3)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7059 (THBS3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    7059 (THBS3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7059 (THBS3)
  Exosomal proteins of colorectal cancer cells
   7059 (THBS3)
  Exosomal proteins of bladder cancer cells
   7059 (THBS3)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   7059 (THBS3)
SSDB
Motif
Pfam: TSP_C TSP_3 COMP EGF_CA EGF_3 cEGF EGF
Other DBs
NCBI-GeneID: 7059
NCBI-ProteinID: NP_009043
OMIM: 188062
HGNC: 11787
Ensembl: ENSG00000169231
UniProt: P49746
LinkDB
Position
1:complement(155195588..155209178)
AA seq 956 aa
METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLS
TFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADG
RTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRM
QGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQ
ILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRC
GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDY
ARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHS
PAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQ
DNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACD
NCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS
CPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD
GDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAE
VTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGT
FHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSG
PGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQL
VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV
NT seq 2871 nt   +upstreamnt  +downstreamnt
atggagacgcaggaacttcggggggccctggctcttctcctcctttgctttttcacatct
gccagtcaggatctgcaggtaattgacctgctgactgtgggcgagtctcggcagatggta
gctgtggcagagaagatccggacagccttgctcactgctggggacatctacctcttatcc
accttccgcctgccccccaagcagggtggtgtcctctttggcctctattctcgccaagac
aacactcgatggctggaggcctctgttgtaggcaagatcaacaaagtactggtgcgatac
cagcgggaggatggcaaagtccacgccgtgaacctacagcaagcgggcctggctgatggg
cgcacacacacagttctcctgcgactccgaggtccctccagacccagccctgccctacat
ctctacgtggactgcaaactgggtgaccaacatgcaggccttccagcactggcccccatt
cctccagcggaggtcgatgggctggagattaggactggacagaaggcgtatttgaggatg
cagggctttgtggaatctatgaaaattattctgggtgggtccatggcccgggtaggagcc
ctgagtgagtgtccattccaaggggacgagtccatccacagtgcagtgaccaatgcactg
cactccattctaggggagcagaccaaggcgctggtcacccaactcaccctcttcaaccag
atcctggtggagctgcgggatgatatacgagaccaggtgaaggaaatgtccctgatccga
aacaccattatggagtgtcaggtgtgcggcttccatgagcagcgttcccactgcagcccc
aatccctgcttccgaggtgtggactgcatggaagtgtacgagtacccaggctaccgctgt
gggccctgcccccctggcctgcagggcaacggcacccactgcagtgacatcaatgagtgt
gctcacgctgacccctgtttcccgggctccagctgcatcaacaccatgcccggcttccac
tgtgaggcctgtcctcgagggtacaagggcacacaggtgtctggtgtgggcattgactat
gcccgggccagcaaacaggtctgcaatgacatcgatgaatgcaacgatggcaacaatggt
ggctgtgacccaaactccatctgcaccaacactgtgggctctttcaagtgtggtccctgc
cgcctgggtttcctgggcaaccagagccagggctgcctcccagcccggacctgccacagc
ccagcccacagcccctgccacatccatgctcactgtctctttgaacgcaatggtgcagtg
tcctgccagtgtaacgtgggctgggctgggaatgggaacgtgtgtgggactgacacagac
atcgatggctacccagaccaagcactgccctgcatggacaacaacaaacactgcaaacag
gacaactgccttttgacacccaactctgggcaggaagatgctgataatgatggtgtgggg
gaccagtgtgatgatgatgctgatggggatgggatcaagaatgttgaggacaactgccgg
ctgttccccaacaaagaccagcagaactcagatacagattcatttggtgatgcctgtgac
aattgccccaacgttcccaacaatgaccagaaggacacagatggcaatggggaaggagat
gcctgtgacaacgacgtggatggggatggcatccccaatggattggacaattgccctaaa
gtccccaacccactacagacagacagggatgaggacggggtgggagatgcttgcgacagc
tgccctgaaatgagcaatcctacccagacagatgcagacagcgacctggtgggggatgtc
tgtgatactaatgaagacagcgatggggatgggcatcaggacaccaaggacaactgccca
cagctgccaaatagctcccagctggactctgataacgatggacttggagatgagtgtgat
ggggatgatgacaatgatggcatcccagattatgtgcctcctggtcccgataactgccgc
ctggtacccaatcccaatcagaaggactcagatggcaatggcgttggtgatgtgtgtgag
gatgactttgacaatgatgctgtggtcgaccccctggatgtgtgtcctgaaagtgcagag
gtaacgcttacggattttcgggcctatcagaccgtcgtcctggatcctgagggtgatgct
cagattgacccaaactgggttgtgctcaaccagggcatggaaatcgttcagaccatgaac
agtgaccctggcttggcagttggatacacggccttcaatggtgtggactttgaaggcacc
ttccatgtgaacacagtgactgatgatgactacgcaggctttctcttcagttatcaagac
agtggccgcttctacgtagtcatgtggaagcagaccgagcagacctactggcaggctaca
cccttccgggcggttgcccagcccgggctgcagctcaaggcagtgacatcagtgtctggc
ccaggtgagcacctccgaaatgccctgtggcatactggccacacccctgatcaggtacga
ctgctgtggacagacccacgaaatgtgggctggcgggacaagacctcctatcgctggcag
cttctgcaccggcctcaagttggctacattcgggtgaagctctatgagggaccccagctt
gtggcggattctggggtgatcattgacacatccatgcgaggggggcgtcttggtgtattc
tgcttctcccaagaaaacataatttggtccaatctccagtatcgatgcaatgacacagtg
cctgaggactttgagccattccggaggcagctgctccagggaagggtgtga

KEGG   Homo sapiens (human): 7060
Entry
7060              CDS       T01001                                 
Symbol
THBS4, TSP-4, TSP4
Name
(RefSeq) thrombospondin 4
  KO
K04659  thrombospondin 2/3/4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04820  Cytoskeleton in muscle cells
hsa05144  Malaria
hsa05165  Human papillomavirus infection
Network
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01990  Integrin alpha3beta1 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    7060 (THBS4)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    7060 (THBS4)
   04518 Integrin signaling
    7060 (THBS4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    7060 (THBS4)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    7060 (THBS4)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    7060 (THBS4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7060 (THBS4)
  09174 Infectious disease: parasitic
   05144 Malaria
    7060 (THBS4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7060 (THBS4)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7060 (THBS4)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7060 (THBS4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    7060 (THBS4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7060 (THBS4)
  Exosomal proteins of colorectal cancer cells
   7060 (THBS4)
  Exosomal proteins of bladder cancer cells
   7060 (THBS4)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   7060 (THBS4)
SSDB
Motif
Pfam: TSP_C TSP_3 COMP EGF_3 EGF cEGF DUF7630
Other DBs
NCBI-GeneID: 7060
NCBI-ProteinID: NP_003239
OMIM: 600715
HGNC: 11788
Ensembl: ENSG00000113296
UniProt: P35443
LinkDB
Position
5:79991332..80083287
AA seq 961 aa
MLAPRGAAVLLLHLVLQRWLAAGAQATPQVFDLLPSSSQRLNPGALLPVLTDPALNDLYV
ISTFKLQTKSSATIFGLYSSTDNSKYFEFTVMGRLNKAILRYLKNDGKVHLVVFNNLQLA
DGRRHRILLRLSNLQRGAGSLELYLDCIQVDSVHNLPRAFAGPSQKPETIELRTFQRKPQ
DFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATGTGDFNRQFLGQMTQLNQLLGEVKDL
LRQQVKETSFLRNTIAECQACGPLKFQSPTPSTVVPPAPPAPPTRPPRRCDSNPCFRGVQ
CTDSRDGFQCGPCPEGYTGNGITCIDVDECKYHPCYPGVHCINLSPGFRCDACPVGFTGP
MVQGVGISFAKSNKQVCTDIDECRNGACVPNSICVNTLGSYRCGPCKPGYTGDQIRGCKA
ERNCRNPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDIDSYPDEELPCSAR
NCKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVLIHNVDQRNSDKDIFG
DACDNCLSVLNNDQKDTDGDGRGDACDDDMDGDGIKNILDNCPKFPNRDQRDKDGDGVGD
ACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIG
DECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICESDFDQDQVIDRIDVCP
ENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVD
FEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVK
SKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYE
GSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQNFDRFD
N
NT seq 2886 nt   +upstreamnt  +downstreamnt
atgctggccccgcgcggagccgccgtcctcctgctgcacctggtcctgcagcggtggcta
gcggcaggcgcccaggccaccccccaggtctttgaccttctcccatcttccagtcagagg
ctaaacccaggcgctctgctgccagtcctgacagaccccgccctgaatgatctctatgtg
atttccaccttcaagctgcagactaaaagttcagccaccatcttcggtctttactcttca
actgacaacagtaaatattttgaatttactgtgatgggacgcttaaacaaagccatcctc
cgttacctgaagaacgatgggaaggtgcatttggtggttttcaacaacctgcagctggca
gacggaaggcggcacaggatcctcctgaggctgagcaatttgcagcgaggggccggctcc
ctagagctctacctggactgcatccaggtggattccgttcacaatctccccagggccttt
gctggcccctcccagaaacctgagaccattgaattgaggactttccagaggaagccacag
gacttcttggaagagctgaagctggtggtgagaggctcactgttccaggtggccagcctg
caagactgcttcctgcagcagagtgagccactggctgccacaggcacaggggactttaac
cggcagttcttgggtcaaatgacacaattaaaccaactcctgggagaggtgaaggacctt
ctgagacagcaggttaaggaaacatcatttttgcgaaacaccatagctgaatgccaggct
tgcggtcctctcaagtttcagtctccgaccccaagcacggtggtgcccccggctccccct
gcaccgccaacacgcccacctcgtcggtgtgactccaacccatgtttccgaggtgtccaa
tgtaccgacagtagagatggcttccagtgtgggccctgccccgagggctacacaggaaac
gggatcacctgtattgatgttgatgagtgcaaataccatccctgctacccgggcgtgcac
tgcataaatttgtctcctggcttcagatgtgacgcctgcccagtgggcttcacagggccc
atggtgcagggtgttgggatcagttttgccaagtcaaacaagcaggtctgcactgacatt
gatgagtgtcgaaatggagcgtgcgttcccaactcgatctgcgttaatactttgggatct
taccgctgtgggccttgtaagccggggtatactggtgatcagataaggggatgcaaagcg
gaaagaaactgcagaaacccagagctgaacccttgcagtgtgaatgcccagtgcattgaa
gagaggcagggggatgtgacatgtgtgtgtggagtcggttgggctggagatggctatatc
tgtggaaaggatgtggacatcgacagttaccccgacgaagaactgccatgctctgccagg
aactgtaaaaaggacaactgcaaatatgtgccaaattctggccaagaagatgcagacaga
gatggcattggcgacgcttgtgacgaggatgctgacggagatgggatcctgaatgagcag
gataactgtgtcctgattcataatgtggaccaaaggaacagcgataaagatatctttggg
gatgcctgtgataactgcctgagtgtcttaaataacgaccagaaagacaccgatggggat
ggaagaggagatgcctgtgatgatgacatggatggagatggaataaaaaacattctggac
aactgcccaaaatttcccaatcgtgaccaacgggacaaggatggtgatggtgtgggggat
gcctgtgacagttgtcctgatgtcagcaaccctaaccagtctgatgtggataatgatctg
gttggggactcctgtgacaccaatcaggacagtgatggagatgggcaccaggacagcaca
gacaactgccccaccgtcattaacagtgcccagctggacaccgataaggatggaattggt
gacgagtgtgatgatgatgatgacaatgatggtatcccagacctggtgccccctggacca
gacaactgccggctggtccccaacccagcccaggaggatagcaacagcgacggagtggga
gacatctgtgagtctgactttgaccaggaccaggtcatcgatcggatcgacgtctgccca
gagaacgcagaggtcaccctgaccgacttcagggcttaccagaccgtggtcctggatcct
gaaggggatgcccagatcgatcccaactgggtggtcctgaaccagggcatggagattgta
cagaccatgaacagtgatcctggcctggcagtggggtacacagcttttaatggagttgac
ttcgaagggaccttccatgtgaatacccagacagatgatgactatgcaggctttatcttt
ggctaccaagatagctccagcttctacgtggtcatgtggaagcagacggagcagacatat
tggcaagccaccccattccgagcagttgcagaacctggcattcagctcaaggctgtgaag
tctaagacaggtccaggggagcatctccggaactccctgtggcacacgggggacaccagt
gaccaggtcaggctgctgtggaaggactccaggaatgtgggctggaaggacaaggtgtcc
taccgctggttcctacagcacaggccccaggtgggctacatcagggtacgattttatgaa
ggctctgagttggtggctgactctggcgtcaccatagacaccacaatgcgtggaggccga
cttggcgttttctgcttctctcaagaaaacatcatctggtccaacctcaagtatcgctgc
aatgacaccatccctgaggacttccaagagtttcaaacccagaatttcgaccgcttcgat
aattaa

KEGG   Homo sapiens (human): 1311
Entry
1311              CDS       T01001                                 
Symbol
COMP, CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5, TSP5
Name
(RefSeq) cartilage oligomeric matrix protein
  KO
K04659  thrombospondin 2/3/4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction
hsa04518  Integrin signaling
hsa04820  Cytoskeleton in muscle cells
hsa05144  Malaria
hsa05165  Human papillomavirus infection
Network
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling
  Element
N01814  Extracellular matrix - Basal lamina
N01921  Integrin alpha4beta1 signaling
N01979  Integrin alphaIIbbeta3 signaling
N01980  Integrin alpha5beta1 signaling
N01983  Integrin alphaVbeta3 signaling
N01990  Integrin alpha3beta1 signaling
Disease
H00476  Multiple epiphyseal dysplasia
H00477  Pseudoachondroplasia
H00798  Familial carpal tunnel syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    1311 (COMP)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    1311 (COMP)
   04518 Integrin signaling
    1311 (COMP)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1311 (COMP)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1311 (COMP)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    1311 (COMP)
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    1311 (COMP)
  09174 Infectious disease: parasitic
   05144 Malaria
    1311 (COMP)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1311 (COMP)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1311 (COMP)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1311 (COMP)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Opsonins
    1311 (COMP)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1311 (COMP)
  Exosomal proteins of colorectal cancer cells
   1311 (COMP)
  Exosomal proteins of bladder cancer cells
   1311 (COMP)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   1311 (COMP)
SSDB
Motif
Pfam: TSP_C TSP_3 EGF_CA EGF_3 COMP cEGF EGF_MSP1_1 EGF DUF7455
Other DBs
NCBI-GeneID: 1311
NCBI-ProteinID: NP_000086
OMIM: 600310
HGNC: 2227
Ensembl: ENSG00000105664
UniProt: P49747
Structure
LinkDB
Position
19:complement(18782773..18791305)
AA seq 757 aa
MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREIT
FLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTG
NGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTD
INECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEH
ADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQ
EDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQK
DTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQAD
VDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDS
RDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLD
PEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFI
FGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDT
ESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGG
RLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA
NT seq 2274 nt   +upstreamnt  +downstreamnt
atggtccccgacaccgcctgcgttcttctgctcaccctggctgccctcggcgcgtccgga
cagggccagagcccgttgggctcagacctgggcccgcagatgcttcgggaactgcaggaa
accaacgcggcgctgcaggacgtgcgggagctgctgcggcagcaggtcagggagatcacg
ttcctgaaaaacacggtgatggagtgtgacgcgtgcgggatgcagcagtcagtacgcacc
ggcctacccagcgtgcggcccctgctccactgcgcgcccggcttctgcttccccggcgtg
gcctgcatccagacggagagcggcgcgcgctgcggcccctgccccgcgggcttcacgggc
aacggctcgcactgcaccgacgtcaacgagtgcaacgcccacccctgcttcccccgagtc
cgctgtatcaacaccagcccggggttccgctgcgaggcttgcccgccggggtacagcggc
cccacccaccagggcgtggggctggctttcgccaaggccaacaagcaggtttgcacggac
atcaacgagtgtgagaccgggcaacataactgcgtccccaactccgtgtgcatcaacacc
cggggctccttccagtgcggcccgtgccagcccggcttcgtgggcgaccaggcgtccggc
tgccagcggcgcgcacagcgcttctgccccgacggctcgcccagcgagtgccacgagcat
gcagactgcgtcctagagcgcgatggctcgcggtcgtgcgtgtgtgccgttggctgggcc
ggcaacgggatcctctgtggtcgcgacactgacctagacggcttcccggacgagaagctg
cgctgcccggagcgccagtgccgtaaggacaactgcgtgactgtgcccaactcagggcag
gaggatgtggaccgcgatggcatcggagacgcctgcgatccggatgccgacggggacggg
gtccccaatgaaaaggacaactgcccgctggtgcggaacccagaccagcgcaacacggac
gaggacaagtggggcgatgcgtgcgacaactgccggtcccagaagaacgacgaccaaaag
gacacagaccaggacggccggggcgatgcgtgcgacgacgacatcgacggcgaccggatc
cgcaaccaggccgacaactgccctagggtacccaactcagaccagaaggacagtgatggc
gatggtataggggatgcctgtgacaactgtccccagaagagcaacccggatcaggcggat
gtggaccacgactttgtgggagatgcttgtgacagcgatcaagaccaggatggagacgga
catcaggactctcgggacaactgtcccacggtgcctaacagtgcccaggaggactcagac
cacgatggccagggtgatgcctgcgacgacgacgacgacaatgacggagtccctgacagt
cgggacaactgccgcctggtgcctaaccccggccaggaggacgcggacagggacggcgtg
ggcgacgtgtgccaggacgactttgatgcagacaaggtggtagacaagatcgacgtgtgt
ccggagaacgctgaagtcacgctcaccgacttcagggccttccagacagtcgtgctggac
ccggagggtgacgcgcagattgaccccaactgggtggtgctcaaccagggaagggagatc
gtgcagacaatgaacagcgacccaggcctggctgtgggttacactgccttcaatggcgtg
gacttcgagggcacgttccatgtgaacacggtcacggatgacgactatgcgggcttcatc
tttggctaccaggacagctccagcttctacgtggtcatgtggaagcagatggagcaaacg
tattggcaggcgaaccccttccgtgctgtggccgagcctggcatccaactcaaggctgtg
aagtcttccacaggccccggggaacagctgcggaacgctctgtggcatacaggagacaca
gagtcccaggtgcggctgctgtggaaggacccgcgaaacgtgggttggaaggacaagaag
tcctatcgttggttcctgcagcaccggccccaagtgggctacatcagggtgcgattctat
gagggccctgagctggtggccgacagcaacgtggtcttggacacaaccatgcggggtggc
cgcctgggggtcttctgcttctcccaggagaacatcatctgggccaacctgcgttaccgc
tgcaatgacaccatcccagaggactatgagacccatcagctgcggcaagcctag

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