KEGG   Homo sapiens (human): 9212
Entry
9212              CDS       T01001                                 
Symbol
AURKB, AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2
Name
(RefSeq) aurora kinase B
  KO
K11479  aurora kinase B [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04110  Cell cycle
Network
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01500  Modifying of condensin I subunits
N01526  Organization of the outer kinetochore
N01529  Recruitment and formation of the MCC
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01561  Microtubule depolymerization
N01563  Inhibition of Kif2A
Drug target
Ilorasertib: D10423
Tinengotinib: D12545
Tozasertib (DG01365): D08279 D08344
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    9212 (AURKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9212 (AURKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9212 (AURKB)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    9212 (AURKB)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9212 (AURKB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9212 (AURKB)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AUR family [OT]
   9212 (AURKB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     9212 (AURKB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     9212 (AURKB)
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     9212 (AURKB)
  Sister chromatid separation proteins
   Aurora kinases
    9212 (AURKB)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1
Other DBs
NCBI-GeneID: 9212
NCBI-ProteinID: NP_001300879
OMIM: 604970
HGNC: 11390
Ensembl: ENSG00000178999
UniProt: Q96GD4
Structure
LinkDB
Position
17:complement(8204731..8210575)
AA seq 344 aa
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
NT seq 1035 nt   +upstreamnt  +downstreamnt
atggcccagaaggagaactcctacccctggccctacggccgacagacggctccatctggc
ctgagcaccctgccccagcgagtcctccggaaagagcctgtcaccccatctgcacttgtc
ctcatgagccgctccaatgtccagcccacagctgcccctggccagaaggtgatggagaat
agcagtgggacacccgacatcttaacgcggcacttcacaattgatgactttgagattggg
cgtcctctgggcaaaggcaagtttggaaacgtgtacttggctcgggagaagaaaagccat
ttcatcgtggcgctcaaggtcctcttcaagtcccagatagagaaggagggcgtggagcat
cagctgcgcagagagatcgaaatccaggcccacctgcaccatcccaacatcctgcgtctc
tacaactatttttatgaccggaggaggatctacttgattctagagtatgccccccgcggg
gagctctacaaggagctgcagaagagctgcacatttgacgagcagcgaacagccacgatc
atggaggagttggcagatgctctaatgtactgccatgggaagaaggtgattcacagagac
ataaagccagaaaatctgctcttagggctcaagggagagctgaagattgctgacttcggc
tggtctgtgcatgcgccctccctgaggaggaagacaatgtgtggcaccctggactacctg
cccccagagatgattgaggggcgcatgcacaatgagaaggtggatctgtggtgcattgga
gtgctttgctatgagctgctggtggggaacccaccctttgagagtgcatcacacaacgag
acctatcgccgcatcgtcaaggtggacctaaagttccccgcttccgtgcccatgggagcc
caggacctcatctccaaactgctcaggcataacccctcggaacggctgcccctggcccag
gtctcagcccacccttgggtccgggccaactctcggagggtgctgcctccctctgccctt
caatctgtcgcctga

KEGG   Homo sapiens (human): 3619
Entry
3619              CDS       T01001                                 
Symbol
INCENP
Name
(RefSeq) inner centromere protein
  KO
K11515  inner centromere protein
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3619 (INCENP)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     3619 (INCENP)
SSDB
Motif
Pfam: INCENP_N INCENP_ARK-bind
Other DBs
NCBI-GeneID: 3619
NCBI-ProteinID: NP_001035784
OMIM: 604411
HGNC: 6058
Ensembl: ENSG00000149503
UniProt: Q9NQS7
Structure
LinkDB
Position
11:62124011..62153169
AA seq 918 aa
MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ
RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
PLQGARVPSSLAYSLKKH
NT seq 2757 nt   +upstreamnt  +downstreamnt
atggggacgacggccccagggcccattcacctgctggagctatgtgaccagaagctcatg
gagtttctctgcaacatggataataaggacttggtgtggcttgaggaaatccaagaggag
gccgagcgcatgttcaccagagaattcagcaaagagccagagctgatgcccaaaacacct
tctcagaagaaccgacggaagaagagacggatttcttatgttcaggatgaaaacagagat
cccatcaggagaaggttatcccgcagaaagtctcggagcagccagctgagctcccgacgc
ctccgcagcaaggacagtgtagagaagctggctacagtggtcggggagaacggctccgtc
ctgcggcgtgtgacccgtgctgcggctgcagctgccgcggctaccatggcattggctgca
ccttcttcacccacccctgagtctcccacgatgctgactaagaagcccgaggataaccac
acccagtgccagctggtgcctgtggtggagatcggcatcagtgagcgccagaatgctgag
cagcatgtcacccagctcatgtccaccgagcctctgccccgcactctgtccccgactcca
gcttcagccacagctccaacctcccagggcatcccgacatcagatgaggaatcaacacct
aagaagtcgaaggccaggatactggagtccatcacagtgagctccctgatggctacaccc
caggaccccaagggtcaaggggtcgggacggggcggtctgcgtctaagctcaggattgcg
caggtctcccctggcccacgggactcgccagcctttccagattctccatggcgggagcgg
gtgctggctcccatcctgccggataacttctccacgcccacgggctctcgcacggactct
caatcggtgcggcacagcccgatcgccccgtcttccccgagtccccaagtcttagcccag
aagtactctctggtggccaaacaggaaagtgttgtccgcagggcgagcagaaggcttgcc
aagaagactgccgaagagccagctgcctctggccgcatcatctgtcacagttacctggag
aggctcctgaatgttgaggtgccccagaaagttggttctgagcagaaggaaccccccgag
gaggctgagcctgtggcggcagctgagccagaggtccctgagaacaatggaaataactcg
tggccccacaatgacacggagattgccaacagcacacccaacccgaagcctgcagccagc
agcccggaaacaccctctgcagggcagcaagaggccaagacggaccaagcagatggaccc
agagagccaccgcagagtgccaggaggaagcgcagctacaagcaggccgtgagtgagctg
gacgaggagcagcacctggaggatgaggagctgcagccccccaggagcaagaccccttcc
tcaccctgcccagccagcaaggtggtacggcccctccggacctttctgcacacagtgcag
aggaaccagatgctcatgaccccgacctcagccccacgcagcgtcatgaagtcctttatt
aagcgcaacactcccctgcgcatggaccccaagtgcagcttcgtcgagaaggagcggcag
cgcctggagaatctgcggcggaaggaggaggccgagcagctgcgcaggcagaaggtggag
gaggacaagcggcggcggctggaggaggtgaagctgaagcgtgaggaacgcctccgcaag
gtgctgcaggcccgcgagcgggtggagcagatgaaggaggagaagaagaagcagattgag
cagaagtttgctcagatcgacgagaagactgagaaggccaaggaggagcggctggcagag
gagaaggccaagaaaaaggcggcggccaagaagatggaggaggtggaagcacgcaggaag
caggaagaggaggcacgtaggctcaggtggctgcagcaggaggaggaagagcggcggcac
caagagctgctgcagaagaagaaggaagaggagcaggagcggctgcggaaggcggccgag
gctaagcggctggcagagcagcgggagcaggagcggcgggagcaggagcggcgcgagcag
gagcggcgcgagcaggagcggcgggagcaggagcggcgcgagcaggagcgacagctggca
gagcaggagcgtcggcgggagcaggagcggctccaggccgagagggagctgcaggagcgg
gagaaggccctgcggctgcagaaggagcagctgcagagggaactggaggagaagaagaag
aaggaagagcagcagcgtctggctgagcggcagctgcaggaggagcaagagaagaaagcc
aaggaggcagcaggggccagcaaggccctgaatgtgactgtggacgtgcagtctccagct
tgtacctcatatcagatgactccgcaagggcacagggcccctcccaagatcaacccagat
aactacgggatggatctgaatagcgacgactccaccgatgatgaggcccatccccggaag
cccatccccacctgggcccgaggcaccccgctcagccaggctatcattcaccagtactac
cacccaccgaaccttctggagctctttggaaccattctcccactggacttggaggatatc
ttcaagaagagcaagccccgctatcacaagcgcaccagctctgctgtctggaactcaccg
cccctgcagggcgccagggtccccagcagcctggcctacagcctgaagaagcactga

KEGG   Homo sapiens (human): 55143
Entry
55143             CDS       T01001                                 
Symbol
CDCA8, BOR, BOREALIN, DasraB, MESRGP
Name
(RefSeq) cell division cycle associated 8
  KO
K11514  Borealin
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    55143 (CDCA8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     55143 (CDCA8)
SSDB
Motif
Pfam: Borealin Nbl1_Borealin_N F-box Axin_b-cat_bind
Other DBs
NCBI-GeneID: 55143
NCBI-ProteinID: NP_001243804
OMIM: 609977
HGNC: 14629
Ensembl: ENSG00000134690
UniProt: Q53HL2
Structure
LinkDB
Position
1:37692516..37709719
AA seq 280 aa
MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILR
LPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLKSAKTRKVIQVD
EMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVS
MVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLR
LLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK
NT seq 843 nt   +upstreamnt  +downstreamnt
atggctcctaggaagggcagtagtcgggtggccaagaccaactccttacggaggcggaag
ctcgcctcctttctgaaagacttcgaccgtgaagtggaaatacgaatcaagcaaattgag
tcagacaggcagaacctcctcaaggaggtggataacctctacaacatcgagatcctgcgg
ctccccaaggctctgcgcgagatgaactggcttgactacttcgcccttggaggaaacaaa
caggccctggaagaggcggcaacagctgacctggatatcaccgaaataaacaaactaaca
gcagaagctattcagacacccctgaaatctgccaaaacacgaaaggtaatacaggtagat
gaaatgatagtggaagaggaagaagaagaagaaaatgaacgtaagaatcttcaaactgca
agagtcaaaaggtgtcctccatccaagaagagaactcagtccatacaaggaaaaggaaaa
gggaaaaggtcaagccgtgctaacactgttaccccagccgtgggccgattggaggtgtcc
atggtcaaaccaactccaggcctgacacccaggtttgactcaagggtcttcaagacccct
ggcctgcgtactccagcagcaggagagcggatttacaacatctcagggaatggcagccct
cttgctgacagcaaagagatcttcctcactgtgccagtgggcggcggagagagcctgcga
ttattggccagtgacttgcagaggcacagtattgcccagctggatccagaggccttggga
aacattaagaagctctccaaccgtctcgcccaaatctgcagcagcatacggacccacaaa
tga

KEGG   Homo sapiens (human): 332
Entry
332               CDS       T01001                                 
Symbol
BIRC5, API4, EPR-1
Name
(RefSeq) baculoviral IAP repeat containing 5
  KO
K08731  baculoviral IAP repeat-containing protein 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04390  Hippo signaling pathway
hsa05161  Hepatitis B
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05210  Colorectal cancer
Network
nt06162  Hepatitis B virus (HBV)
nt06214  PI3K signaling (cancer)
nt06215  WNT signaling (cancer)
nt06230  Cell cycle (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06271  Endometrial cancer
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01526  Organization of the outer kinetochore
Drug target
Gataparsen (DG01431): D09909 D09910
Sepantronium bromide: D10164
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    332 (BIRC5)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    332 (BIRC5)
   04215 Apoptosis - multiple species
    332 (BIRC5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    332 (BIRC5)
   05207 Chemical carcinogenesis - receptor activation
    332 (BIRC5)
  09162 Cancer: specific types
   05210 Colorectal cancer
    332 (BIRC5)
  09172 Infectious disease: viral
   05161 Hepatitis B
    332 (BIRC5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    332 (BIRC5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    332 (BIRC5)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    332 (BIRC5)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I32: IAP family
   332 (BIRC5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     332 (BIRC5)
SSDB
Motif
Pfam: BIR
Other DBs
NCBI-GeneID: 332
NCBI-ProteinID: NP_001159
OMIM: 603352
HGNC: 593
Ensembl: ENSG00000089685
UniProt: O15392 A0A0B4J1S3
Structure
LinkDB
Position
17:78214253..78225635
AA seq 142 aa
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAEKVRRAIEQLAAMD
NT seq 429 nt   +upstreamnt  +downstreamnt
atgggtgccccgacgttgccccctgcctggcagccctttctcaaggaccaccgcatctct
acattcaagaactggcccttcttggagggctgcgcctgcaccccggagcggatggccgag
gctggcttcatccactgccccactgagaacgagccagacttggcccagtgtttcttctgc
ttcaaggagctggaaggctgggagccagatgacgaccccatagaggaacataaaaagcat
tcgtccggttgcgctttcctttctgtcaagaagcagtttgaagaattaacccttggtgaa
tttttgaaactggacagagaaagagccaagaacaaaattgcaaaggaaaccaacaataag
aagaaagaatttgaggaaactgcggagaaagtgcgccgtgccatcgagcagctggctgcc
atggattga

KEGG   Homo sapiens (human): 1060
Entry
1060              CDS       T01001                                 
Symbol
CENPC, CENP-C, CENPC1, MIF2, hcp-4
Name
(RefSeq) centromere protein C
  KO
K11497  centromere protein C
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01525  Organization of the inner kinetochore
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    1060 (CENPC)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    Centromere proteins
     1060 (CENPC)
    Mis6 complex
     1060 (CENPC)
SSDB
Motif
Pfam: CENP_C_N CENP-C_mid CENP-C_C Cupin_2
Other DBs
NCBI-GeneID: 1060
NCBI-ProteinID: NP_001803
OMIM: 117141
HGNC: 1854
Ensembl: ENSG00000145241
UniProt: Q03188
Structure
LinkDB
Position
4:complement(67468762..67545503)
AA seq 943 aa
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP
NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI
LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK
RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS
GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE
DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN
DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK
QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP
VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV
YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS
GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG
YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP
KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK
RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL
VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL
CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR
NT seq 2832 nt   +upstreamnt  +downstreamnt
atggctgcgtccggtctggatcatctcaaaaatggctacagaagaagattttgtcgacct
tccagggcacgtgacattaacacagagcaaggccagaatgttctggaaatcttacaagac
tgttttgaagaaaaaagtcttgccaatgattttagtacaaattctacaaaatcagtgcct
aattcaacacgcaaaataaaagacacttgtattcagtcaccaagcaaagagtgccagaaa
tcacatccaaagtcagttccagtttcttcaaagaagaaagaagcctctctacagtttgtt
gtagaaccaagtgaagccacaaacagatcagttcaggcccatgaagttcatcagaaaatt
ctggcaactgatgttagttccaaaaatacacctgactcgaaaaaaatatcaagtagaaac
ataaatgatcatcacagtgaagctgatgaagaattttacttatccgttggctcaccttct
gttcttttggatgcaaaaacatctgtatcacaaaatgttattccatctagtgcccaaaag
agagagacttacacttttgaaaattcagtaaatatgctgccttcaagtacagaggtttca
gttaaaaccaaaaaaaggttaaactttgatgataaagttatgttaaagaaaatagaaata
gataataaagtatcagatgaagaggataaaacatcggaaggacaagaaagaaaaccatca
ggatcatctcagaatagaatacgagattcagaatatgaaattcaacgacaagctaaaaaa
agtttttcaacattgtttttagaaacagtaaaacgaaaaagtgaatccagtcccattgtt
aggcatgcggcaactgctccacctcattcgtgtcctcccgatgatacgaagttgatagag
gatgaatttataattgatgagtcggatcaaagttttgccagtagatcttggattacaata
ccaagaaaggcagggtctctgaaacaacgcacaatatccccggctgagagcactgcactc
cttcaaggtagaaagtcaagagaaaagcatcataatatattacctaagactttggcaaat
gacaaacattcccataaacctcacccagtagagacatctcagccctctgataaaacagta
ctggatacaagttatgctttgataggtgaaacagtaaataattatagatctacaaaatat
gaaatgtattccaagaatgcagaaaaaccatctagaagcaaaaggactataaaacaaaaa
cagagaagaaaattcatggctaaaccagctgaagaacagcttgatgtgggacagtctaaa
gatgaaaacatacatacatcacatattacccaagacgaatttcaaagaaattcagacaga
aatatggaagagcatgaagagatgggaaatgattgtgtttccaaaaaacagatgccacct
gtgggaagcaagaaaagtagcactagaaaagataaggaagaatctaaaaagaagcgcttt
tccagtgagtccaagaacaaacttgtacctgaagaagtgacttcaactgtcacgaaaagt
cgaagaatttccaggcgtccatctgattggtgggtggtaaaatcagaggagagtcctgtt
tatagcaattcttcagtaagaaatgaattaccaatgcatcacaatagtagccgaaaatct
actaagaaaacaaatcagtcatctaagaatattaggaaaaaaactattccacttaaaagg
cagaagacagcaactaaaggcaaccaaagagtacagaagtttttaaatgctgaaggttct
ggaggtatcgttggtcatgatgaaatttccagatgttcgctgagtgagccattggaaagt
gatgaggcagacttggctaagaagaaaaatcttgattgttctagatctacaagaagctca
aagaatgaagataacattatgactgcacagaatgttcccctaaagcctcagaccagtgga
tatacatgtaatataccaacagagtcaaacttggattctggagagcataagacttcagtt
ttagaggaaagtggaccttccaggctcaataataattatttaatgtctggaaagaatgat
gtggatgatgaggaagttcatggaagttcagatgactcaaaacaatctaaagtgatacca
aagaacagaatccatcacaaactagtattgccctccaacacaccaaatgttcgcaggacc
aagagaacacgtttgaaacctttggagtactggcgaggagagcgaatagattatcaagga
aggccatcaggaggattcgtgattagtggagtactatctccagacacaatatcgtctaaa
aggaaggcaaaagaaaatattggaaaagtcaacaaaaaatctaataagaaaaggatctgt
cttgataacgatgaaagaaagactaacttaatggtaaatctaggtatacctcttggagat
cctttgcagccaacgagggtaaaggacccagaaacaagagagattattctcatggatctt
gtaaggccacaagatacatatcaattttttgttaagcatggtgagttgaaggtatacaag
acattggatacaccctttttttctactgggaaattgatattaggaccacaagaagaaaag
ggaaagcagcatgttggccaggatatattggttttttatgttaactttggtgaccttttg
tgtactttacatgaaacaccttatatattaagtactggggattcgttctatgttccttca
ggtaactattataacatcaaaaatctccggaatgaggaaagtgttcttctttttactcag
ataaaaagatga

KEGG   Homo sapiens (human): 79003
Entry
79003             CDS       T01001                                 
Symbol
MIS12, 2510025F08Rik, KNTC2AP, MTW1, hMis12
Name
(RefSeq) MIS12 kinetochore complex component
  KO
K11543  kinetochore-associated protein MIS12
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
N01532  Kinetochore targeting of MAD1-MAD2
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    79003 (MIS12)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     MIS12 complex
      79003 (MIS12)
SSDB
Motif
Pfam: Mis12 ResIII SpecificRecomb DUF7809
Other DBs
NCBI-GeneID: 79003
NCBI-ProteinID: NP_001245146
OMIM: 609178
HGNC: 24967
Ensembl: ENSG00000167842
UniProt: Q9H081
Structure
LinkDB
Position
17:5486374..5490811
AA seq 205 aa
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQI
RKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKE
IEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVS
LVQNSRKLQNIRDNVEKESKRLKIS
NT seq 618 nt   +upstreamnt  +downstreamnt
atgtctgtggatccaatgacctacgaggcccagttctttggcttcacgccacaaacgtgc
atgcttcggatctacattgcatttcaagactacctatttgaagtgatgcaggccgttgaa
caggttattctgaagaagctggatggcatcccagactgtgacattagcccagtgcagatt
cgcaaatgcacagagaagtttctttgcttcatgaaaggacattttgataacctttttagc
aaaatggagcaactgtttttgcagctgattttacgtattccctcaaacatcttgcttcct
gaagataaatgtaaggagacaccttatagtgaggaagattttcagcatctccagaaagaa
attgaacagttacaggagaagtacaagactgaattatgtactaagcaggcccttcttgca
gaattagaagagcaaaaaattgttcaggccaaactcaaacagacgttgactttctttgat
gagcttcataatgttggcagagatcatgggactagtgattttagggagagtttagtatcc
ctggttcagaactccagaaaactacagaacattagagacaatgtggaaaaggaatcgaaa
cgactgaaaatatcttaa

KEGG   Homo sapiens (human): 79980
Entry
79980             CDS       T01001                                 
Symbol
DSN1, C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3
Name
(RefSeq) DSN1 component of MIS12 kinetochore complex
  KO
K11544  kinetochore-associated protein DSN1
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    79980 (DSN1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     MIS12 complex
      79980 (DSN1)
SSDB
Motif
Pfam: MIS13 CA109-like
Other DBs
NCBI-GeneID: 79980
NCBI-ProteinID: NP_001138787
OMIM: 609175
HGNC: 16165
Ensembl: ENSG00000149636
UniProt: Q9H410
Structure
LinkDB
Position
20:complement(36751795..36773763)
AA seq 356 aa
MTSVTRSEIIDEKGPVMSKTHDHQLESSLSPVEVFAKTSASLEMNQGVSEERIHLGSSPK
KGGNCDLSHQERLQSKSLHLSPQEQSASYQDRRQSWRRASMKETNRRKSLHPIHQGITEL
SRSISVDLAESKRLGCLLLSSFQFSIQKLEPFLRDTKGFSLESFRAKASSLSEELKHFAD
GLETDGTLQKCFEDSNGKASDFSLEASVAEMKEYITKFSLERQTWDQLLLHYQQEAKEIL
SRGSTEAKITEVKVEPMTYLGSSQNEVLNTKPDYQKILQNQSKVFDCMELVMDELQGSVK
QLQAFMDESTQCFQKVSVQLGKRSMQQLDPSPARKLLKLQLQNPPAIHGSGSGSCQ
NT seq 1071 nt   +upstreamnt  +downstreamnt
atgacttcagtgactagatcagagatcatagatgaaaaaggaccagtgatgtctaagact
catgatcatcaattggaatcaagtctcagtcctgtggaagtgtttgctaaaacatctgcc
tccctggagatgaatcaaggcgtttcagaggaaagaattcaccttggctctagccctaaa
aaagggggaaattgtgatctcagccaccaggaaagacttcagtcgaagtcccttcatttg
tctcctcaagaacaatctgccagttatcaagacaggaggcaatcctggcggcgagcaagt
atgaaagaaacgaaccggcggaagtcgctgcatcccattcaccagggcatcacagagctc
agccggtctatcagtgtcgatttagcagaaagcaaacggcttggctgtctcctgctttcc
agtttccagttctctattcagaaacttgaacctttcctaagggacactaagggcttcagt
cttgaaagttttagagccaaagcatcttctctttctgaagaattgaaacattttgcagac
ggactggaaactgatggaactctacaaaaatgttttgaagattcaaatggaaaagcatca
gatttttctttggaagcatctgtggctgagatgaaggaatacataacaaagttttcttta
gaacgtcagacttgggatcagctcttgcttcactaccagcaggaggctaaagagatattg
tccagaggatcaactgaggccaaaattactgaggtcaaagtggaacctatgacatatctt
gggtcttctcagaatgaagttcttaatacaaaacctgactaccagaaaatattacagaac
cagagcaaagtctttgactgtatggagttggtgatggatgaactgcaaggatcagtgaaa
cagctgcaggcctttatggatgaaagtacccagtgcttccagaaggtgtcagtacagctc
ggaaagagaagcatgcaacaattagatccctcaccagctcgaaaactgttgaagcttcag
ctacagaacccacctgccatacatggatctggatctggatcttgtcagtga

KEGG   Homo sapiens (human): 11243
Entry
11243             CDS       T01001                                 
Symbol
PMF1
Name
(RefSeq) polyamine modulated factor 1
  KO
K11546  polyamine-modulated factor 1
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    11243 (PMF1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     MIS12 complex
      11243 (PMF1)
SSDB
Motif
Pfam: Nnf1 SYCP2_ARLD DUF7603 CENPU Mod_r
Other DBs
NCBI-GeneID: 11243
NCBI-ProteinID: NP_009152
OMIM: 609176
HGNC: 9112
Ensembl: ENSG00000160783
UniProt: Q6P1K2
Structure
LinkDB
Position
1:156213007..156240042
AA seq 205 aa
MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTD
CYKCFYQLQPAMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKE
PAWRPSGIPEKDLHSVMAPYFLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQV
QAQQQAWQALHREQRELVAVLREPE
NT seq 618 nt   +upstreamnt  +downstreamnt
atggccgaagcaagtagcgccaatctaggcagcggctgtgaggaaaaaaggcatgagggg
tcgtcttcggaatctgtgccacccggcactaccatttcgagggtgaagctcctcgacacc
atggtggacacttttcttcagaagctggtcgccgccggcagctaccagagattcactgac
tgctataagtgcttctaccagttgcagcctgcgatgacacagcaaatctatgacaagttt
atagctcagttgcagacatctatccgggaggaaatctctgacatcaaagaggaggggaac
ctagaagctgtcttgaatgccttggataaaattgtggaagaaggcaaagtccgcaaagag
ccagcctggcgccccagcgggatcccagagaaggatctgcacagtgttatggcaccctac
ttcctgcagcaacgggacaccctgcggcgccatgtgcagaaacaggaggccgagaaccag
cagctggcagatgccgtcctggcagggcggaggcaggtggaggagctgcagctacaggtc
caggcccagcagcaggcctggcaggctctacacagagaacagagggagctggttgctgtg
ctgagggagcctgagtga

KEGG   Homo sapiens (human): 25936
Entry
25936             CDS       T01001                                 
Symbol
NSL1, C1orf48, DC8, MIS14
Name
(RefSeq) NSL1 component of MIS12 kinetochore complex
  KO
K11545  kinetochore-associated protein NSL1
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    25936 (NSL1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     MIS12 complex
      25936 (NSL1)
SSDB
Motif
Pfam: Mis14 CYP38_PsbQ-like
Other DBs
NCBI-GeneID: 25936
NCBI-ProteinID: NP_056286
OMIM: 609174
HGNC: 24548
Ensembl: ENSG00000117697
UniProt: Q96IY1 Q53FM2
Structure
LinkDB
Position
1:complement(212726153..212791777)
AA seq 281 aa
MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL
GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV
DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV
AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE
TTPTETASRKTSDMVLKRKQTKDCPQRKWYPLRPKKINLDT
NT seq 846 nt   +upstreamnt  +downstreamnt
atggcggggtctcctgagttggtggtccttgaccctccatgggacaaggagctcgcggct
ggcacagagagccaggccttggtctccgccactccccgagaagactttcgggtgcgctgc
acctcgaagcgggctgtgaccgaaatgctacaactgtgcggccgcttcgtgcaaaagctc
ggggacgctctgccggaggagattcgggagcccgctctgcgagatgcgcagtggactttt
gaatcagctgtgcaagagaatatcagcattaatgggcaagcatggcaggaagcttcagat
aattgttttatggattctgacatcaaagtacttgaagatcagtttgatgaaatcatagta
gatatagccacaaaacgtaagcagtatcccagaaagatcctggaatgtgtcatcaaaacc
ataaaagcaaaacaagaaattctgaagcagtaccaccctgttgtacatccactggaccta
aaatatgaccctgatccagcccctcatatggaaaatttgaaatgcagaggggaaacagta
gcaaaggagatcagtgaagccatgaagtccttgcctgcattaattgaacaaggagaggga
ttttcccaagttctcaggatgcagcctgttatccacctccagaggattcaccaagaagtc
ttttccagttgtcataggaaaccagatgctaaacctgagaactttataacacagatagaa
accacaccaacagagactgcttccaggaaaacctctgacatggtactgaaaagaaagcaa
actaaagactgcccccagagaaaatggtatccattgcggccaaagaaaattaatcttgat
acatga

KEGG   Homo sapiens (human): 57082
Entry
57082             CDS       T01001                                 
Symbol
KNL1, AF15Q14, CASC5, CT29, D40, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105
Name
(RefSeq) kinetochore scaffold 1
  KO
K11542  protein CASC5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
N01529  Recruitment and formation of the MCC
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    57082 (KNL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    57082 (KNL1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    57082 (KNL1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     57082 (KNL1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     57082 (KNL1)
SSDB
Motif
Pfam: MELT Knl1_RWD_C
Other DBs
NCBI-GeneID: 57082
NCBI-ProteinID: NP_733468
OMIM: 609173
HGNC: 24054
Ensembl: ENSG00000137812
UniProt: Q8NG31
Structure
LinkDB
Position
15:40594249..40664342
AA seq 2342 aa
MDGVSSEANEENDNIERPVRRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVS
FADTIKVFQTESHMKIVRKSEMEGCSAMVPSQLQLLPPGFKRFSCLSLPETETGENLLLI
QNKKLEDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLT
SSHTVMITKGLLDNPISEKSTKIDTTSFLANLKLHTEDSRMKKEVNFSVDQNTSSENKID
FNDFIKRLKTGKCSAFPDVPDKENFEIPIYSKEPNSASSTHQMHVSLKEDENNSNITRLF
REKDDGMNFTQCHTANIQTLIPTSSETNSRESKGNDITIYGNDFMDLTFNHTLQILPATG
NFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQNTAFQDLSINSADKIHITRSHIMGAE
THIVSQTCNQDARILAMTPESIYSNPSIQGCKTVFYSSCNDAMEMTKCLSNMREEKNLLK
HDSNYAKMYCNPDAMSSLTEKTIYSGEENMDITKSHTVAIDNQIFKQDQSNVQIAAAPTP
EKEMMLQNLMTTSEDGKMNVNCNSVPHVSKERIQQSLSNPLSISLTDRKTELLSGENMDL
TESHTSNLGSQVPLAAYNLAPESTSESHSQSKSSSDECEEITKSRNEPFQRSDIIAKNSL
TDTWNKDKDWVLKILPYLDKDSPQSADCNQEIATSHNIVYCGGVLDKQITNRNTVSWEQS
LFSTTKPLFSSGQFSMKNHDTAISSHTVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMII
CSEEEQNMDLTKSHTVVIGFGPSELQELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPIE
KSGVLKSNCIMDVLEDESVQKPKFPKEKQNVKIWGRKSVGGPKIDKTIVFSEDDKNDMDI
TKSYTIEINHRPLLEKRDCHLVPLAGTSETILYTCRQDDMEITRSHTTALECKTVSPDEI
TTRPMDKTVVFVDNHVELEMTESHTVFIDYQEKERTDRPNFELSQRKSLGTPTVICTPTE
ESVFFPGNGESDRLVANDSQLTPLEEWSNNRGPVEVADNMELSKSATCKNIKDVQSPGFL
NEPLSSKSQRRKSLKLKNDKTIVFSENHKNDMDITQSCMVEIDNESALEDKEDFHLAGAS
KTILYSCGQDDMEITRSHTTALECKTLLPNEIAIRPMDKTVLFTDNYSDLEVTDSHTVFI
DCQATEKILEENPKFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVGNKIVLHTEQKQQLF
AATNRTTNEIIKFHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNRDRRNVDFTSSHATA
VCGSSDNYSCLPNVISCTDNLEGSAMLLCDKDEEKANYCPVQNDLAYANDFASEYYLESE
GQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHKDQDLIKDPRNLLANQTLVYSQDLGEMT
KLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPKKGQSSINKEEVILSKAGNKS
LNIIENSSAPICENKPKILNSEEWFAAACKKELKENIQTTNYNTALDFHSNSDVTKQVIQ
THVNAGEAPDPVITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLPPLPEQLLELGNKAH
NDMHIVQATEIHNINIISSNAKDSRDEENKKSHNGAETTSLPPKTVFKDKVRRCSLGIFL
PRLPNKRNCSVTGIDDLEQIPADTTDINHLETQPVSSKDSGIGSVAGKLNLSPSQYINEE
NLPVYPDEINSSDSINIETEEKALIETYQKEISPYENKMGKTCNSQKRTWVQEEEDIHKE
KKIRKNEIKFSDTTQDREIFDHHTEEDIDKSANSVLIKNLSRTPSSCSSSLDSIKADGTS
LDFSTYRSSQMESQFLRDTICEESLREKLQDGRITIREFFILLQVHILIQKPRQSNLPGN
FTVNTPPTPEDLMLSQYVYRPKIQIYREDCEARRQKIEELKLSASNQDKLLVDINKNLWE
KMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTHQGKVALYGKLVQSAQNEREKLQIKIDE
MDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLL
ELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVEWSDDQAVFTFVYDTIQLTITF
EESVVGFPFLDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQH
QLPKMLEEFSLVVHHCRLLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEI
TLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQDCHF
YH
NT seq 7029 nt   +upstreamnt  +downstreamnt
atggatggggtgtcttcagaggctaatgaagaaaatgacaatatagagagacctgttaga
agacggcattcttcaatattgaaacccccaaggagtcctcttcaggacctcagaggtggg
aatgaaagagttcaggaatccaatgctttgagaaataagaaaaactctcgtcgagtcagc
tttgcagatactataaaggtattccagacggagtctcatatgaaaatagtgagaaagtca
gaaatggaaggctgcagtgcaatggtgccatctcagctgcaacttctgcctcctgggttt
aagcgattctcctgcctcagcctcccagaaacagaaacaggagaaaatcttcttttgata
cagaataagaaattagaagataattactgtgaaattactgggatgaacacattgctttct
gctcccattcatacccagatgcaacagaaggagttttcaattatagaacatacccgtgaa
aggaaacatgcaaatgaccagacagtcattttttcagatgaaaaccagatggacctgaca
tcaagtcacactgtaatgattaccaaaggccttttagataatcccataagtgaaaagtcc
accaagatagataccacatcatttctagctaatttaaagcttcacaccgaggactcaaga
atgaaaaaagaagtaaatttttccgtggatcaaaacacttcttcagaaaataaaatagat
ttcaatgacttcataaaaagattgaaaacaggaaaatgtagtgcttttcctgatgtgcct
gataaagaaaattttgagatacctatttattccaaggaaccgaacagtgcctcttctaca
catcaaatgcatgtatctcttaaggaagatgaaaataacagtaatattactaggctcttt
agagaaaaagatgatgggatgaatttcacccagtgtcatacagccaatattcagacattg
attcccacatccagtgagaccaactcacgggaatctaaaggtaatgatattacaatttat
ggcaatgactttatggacttgacatttaaccacactttgcagatcttacctgcaacaggt
aatttttctgaaatagaaaatcaaactcagaatgccatggatgtaacaacaggttatgga
actaaagcttcaggaaataaaacagtttttaagagtaaacaaaatactgcttttcaagac
ctttccataaactctgcagacaaaatacatattaccagaagtcatattatgggggcagaa
actcacatagtctcacagacttgtaatcaggatgccagaatattagccatgaccccagaa
tctatatattctaatccatctattcaaggttgtaagactgttttctattctagttgtaat
gatgccatggaaatgaccaaatgtctctcaaatatgagagaggagaaaaatttgctaaag
catgacagtaattatgctaaaatgtattgcaatccagatgctatgtcttctctcacagag
aaaactatttattccggagaggagaacatggacattaccaagagtcatacagttgcaata
gataatcaaatttttaaacaagatcaatcaaatgtgcaaatagcagctgcaccaacaccc
gaaaaagaaatgatgctccaaaatcttatgaccacatcagaagatgggaaaatgaatgta
aattgtaactcagttcctcatgtatctaaggaaagaatacagcagagcctgtcaaatcct
ttgtctatttcattgactgatagaaagactgaactcttatcaggtgaaaatatggatttg
actgaaagtcacacaagtaacttaggaagtcaggttcctcttgcagcttataatctagca
ccggagagtaccagtgaatctcactctcagagcaaaagctcttcagatgaatgtgaagaa
attaccaaaagtcgtaatgaaccatttcagcgatcagacataatagccaaaaacagctta
accgacacctggaacaaagacaaagattgggttttgaagattttgccctaccttgataaa
gattctcctcagtcagctgattgtaatcaggagatagcaacaagccataatatagtctac
tgtggtggagttcttgataaacaaataactaatagaaatacagtatcatgggaacaatct
ttgttttctaccacaaagccattattttcatcaggacagttctctatgaaaaatcatgat
actgctataagtagtcatacagtgaaatctgtactaggccagaattctaaactggctgag
ccactgaggaaaagtttaagcaatcccacacctgactattgccatgacaagatgattata
tgttcagaggaagagcaaaatatggatctaacaaagagccacactgtcgtcattggattt
ggtccttctgaactacaagaacttggtaaaactaatttagaacacactactggccagcta
acaacaatgaacagacagatagctgtaaaagttgaaaaatgtggtaaaagtcccatagaa
aaaagtggagtgcttaaatctaactgtattatggatgtgttagaggacgaaagtgtacag
aaacctaaatttccaaaggaaaagcaaaatgtcaaaatttggggaaggaaaagtgttggt
ggaccaaaaattgataagactattgtattttcagaagacgataagaatgatatggatatc
actaagagttatacaatagaaataaaccatagacctttattagagaaacgtgattgtcat
ttggtgccattggcaggaacttctgaaactattttatatacatgtaggcaggatgacatg
gagatcactagaagtcacacaactgccttagaatgtaaaactgtctcaccagatgaaata
actactaggcctatggacaaaactgtagtgtttgtagataatcatgttgaactagaaatg
acagagtcccatactgttttcattgactaccaagaaaaggaaagaacagacagacctaac
tttgaactatcccaaaggaaaagcctaggaacaccaacagtgatatgtactcctactgag
gagagtgttttctttccaggaaatggtgaaagtgaccgtctagtagcaaatgacagccag
ctaacccctctggaggaatggtctaataataggggccctgtagaggtagctgataacatg
gaattgtctaaatcagccacttgcaaaaacatcaaagatgtacaaagtcctggatttctg
aatgaacctctatcaagcaaaagtcagagaagaaaaagccttaagctaaaaaatgacaag
accattgtattttcagagaatcataaaaatgatatggatattacccagagttgtatggtg
gaaatagataacgaaagtgccctggaggataaagaggacttccatttggcaggggcttct
aaaactattttgtattcatgtgggcaggatgacatggagatcactaggagtcacacaact
gccttagaatgtaaaactctcctgccaaatgaaatagctattaggcccatggacaaaacc
gtattgttcacagataattacagtgatctggaagtcaccgattcccatactgttttcatt
gactgtcaagccacagagaaaatacttgaagaaaaccctaaatttggaataggaaaagga
aaaaacttgggtgtttcctttcctaaggataatagctgtgttcaagaaatcgctgaaaaa
caagcactggctgtaggaaacaaaatagttcttcacaccgagcaaaagcaacaactcttt
gctgctactaatagaactactaatgaaatcatcaaatttcatagtgctgctatggatgaa
aaggtcatagggaaagttgtagaccaggcctgtacattggaaaaagcgcaagttgaaagc
tgtcagttaaataatagagatagaagaaatgtggactttacaagtagtcatgcaactgct
gtttgtggatccagtgataattattcctgtttaccaaatgttatttcctgtactgataat
ttggagggtagtgccatgctcttatgtgataaagatgaggaaaaagccaattattgccca
gtgcaaaatgatcttgcttatgcaaatgattttgccagtgaatattacttggaatctgag
ggacagcctctctctgctccttgtcctttgttagagaaggaagaagttattcaaaccagt
accaaaggacagttagactgtgttataacactgcacaaagatcaagatctgattaaggat
ccacgaaatctattggctaatcaaactttagtatatagtcaagatctgggggagatgact
aaacttaattcaaagcgagtatcttttaagcttccaaaggatcaaatgaaagtctatgtt
gatgacatttatgttattcctcagcctcatttctcaaccgaccaacctccattacctaaa
aaaggacagagtagtatcaataaagaagaagtaatactgtctaaagctggaaataagagt
ttaaatattatagaaaattcctctgcacccatatgtgaaaacaagcccaaaatactcaat
agtgaggaatggtttgctgcagcctgtaaaaaagaactgaaggaaaatattcaaacaact
aactataatacagctctagatttccacagtaactcagacgtaactaagcaagtcattcaa
actcatgtcaatgctggagaagcaccagatcctgtaattacatctaatgttccatgtttt
catagtatcaaaccaaatctgaataatttgaatggaaaaactggagagtttttagccttt
caaactgttcatctaccaccccttccagagcaattacttgaattaggaaataaggcacac
aatgatatgcatatagtgcaagctacagaaatacataatattaacataatctccagcaat
gctaaagatagtagagatgaggaaaataaaaagtctcataatggagctgaaaccacctct
ctaccgccaaagacagtttttaaagataaagtaaggagatgttctttgggaatctttttg
cctagattgcccaacaagagaaattgtagtgtcactggtattgatgacctggaacagatt
ccagcagacacaactgatataaatcacttagaaactcagccggtctctagcaaagattca
ggcattggatctgttgcaggtaaactgaacctaagtccttctcaatatataaatgaggaa
aatcttcctgtatatcctgatgagatcaattcttcagactctattaacatagaaactgag
gaaaaggccttgattgagacataccaaaaagagatttcaccatatgaaaataaaatggga
aaaacttgcaatagccaaaaaagaacgtgggtacaagaagaagaagatattcataaggag
aaaaaaatcagaaaaaatgagattaagtttagtgatacgacacaagatcgggagattttt
gatcaccatactgaagaggatatagataaaagtgctaacagtgtattgataaaaaacctg
agcaggaccccatctagttgcagcagctctctggattcaatcaaggctgatgggacctct
ctggacttcagcacttaccgcagtagtcaaatggaatcacagtttctcagagatactatt
tgtgaagagagcttgagggagaaactccaagatgggagaataacaataagggagttcttt
atacttctccaggtccacatcttgatacagaaaccccgacagagcaatctcccaggcaat
tttactgtaaacacaccacctactccagaagacctgatgttaagtcaatatgtttaccga
cccaagatacagatttatagagaagattgtgaggctcgtcgccaaaagattgaagaatta
aagctttctgcatcgaaccaagataagctgttggttgatataaataagaacctgtgggaa
aaaatgagacactgctctgacaaagagctgaaggcctttggaatttatcttaacaaaata
aagtcatgttttaccaagatgactaaagtcttcactcaccaaggaaaagtggctctgtat
ggcaagctggtgcagtcagctcagaatgagagggagaaacttcaaataaagatagatgag
atggataaaatacttaagaagatcgataactgcctcactgagatggaaacagaaactaag
aatttggaggatgaagagaaaaacaatcctgtggaagaatgggattctgaaatgagagct
gcagaaaaagaattggaacagctgaaaactgaagaagaggagcttcaaagaaatctctta
gaactggaggtacaaaaagagcagacccttgctcaaatagactttatgcaaaaacaaaga
aatagaactgaagagctactggatcagttgagcttgtctgagtgggatgtcgttgagtgg
agtgatgatcaagctgtattcacctttgtttatgacacgatacaactcaccatcaccttt
gaagagtcagttgttggtttccctttcctggacaagcgttataggaagattgttgatgtc
aattttcaatctctgttagatgaggatcaagctcctccttcctcccttttagttcataag
cttattttccagtacgttgaagaaaaggaatcctggaagaagacatgtacaacccagcat
cagttacccaagatgcttgaagaattctcactggtagtgcaccattgcagactccttgga
gaggagattgagtatttaaagagatggggaccaaattataacctaatgaacatagatatt
aataataatgaattgagacttttattctctagctccgcagcatttgcaaagtttgaaata
actttgtttctctcagcctattatccatctgtaccattaccttccaccattcagaatcac
gttgggaacactagccaagatgatattgctaccattctatctaaagtgccactggagaac
aactacctgaagaatgtagtcaagcaaatttaccaagatctgtttcaggactgccatttc
taccactag

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