KEGG   PATHWAY: ko00071Help
Entry
ko00071                     Pathway                                

Name
Fatty acid degradation
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ko00071  Fatty acid degradation
ko00071

Ortholog table
Module
M00086  beta-Oxidation, acyl-CoA synthesis [PATH:ko00071]
M00087  beta-Oxidation [PATH:ko00071]
Disease
H00162  Sjogren-Larsson syndrome
H00178  Glutaric acidemia
H00375  SBCAD deficiency
H00392  VLCAD deficiency
H00488  MCAD deficiency
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01352  Mitochondrial trifunctional protein deficiency
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
H01400  Secondary hyperammonemia
H01980  SCAD deficiency
H01981  Carnitine palmitoyltransferase I deficiency
H01982  Carnitine palmitoyltransferase II deficiency
H02096  Peroxisomal acyl-CoA oxidase deficiency
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K00255  long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K09478  short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12]
K09479  very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01897  long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013  long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08765  carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523  carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524  carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K08766  carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K01909  long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20]
K05939  acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
K13238  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K13239  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K07517  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K18880  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K00496  alkane 1-monooxygenase [EC:1.14.15.3]
K07425  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K15401  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K20495  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K22887  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K05297  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K21738  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K22567  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  alcohol dehydrogenase [EC:1.1.1.1]
K18857  alcohol dehydrogenase class-P [EC:1.1.1.1]
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00071  Aldehyde
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00226  Primary alcohol
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00332  Acetoacetyl-CoA
C00340  Reduced rubredoxin
C00435  Oxidized rubredoxin
C00489  Glutarate
C00517  Hexadecanal
C00527  Glutaryl-CoA
C00638  Long-chain fatty acid
C00823  1-Hexadecanol
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01371  Alkane
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02990  L-Palmitoylcarnitine
C03221  2-trans-Dodecenoyl-CoA
C03547  omega-Hydroxy fatty acid
C03561  (R)-3-Hydroxybutanoyl-CoA
C05102  alpha-Hydroxy fatty acid
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C05279  trans,cis-Lauro-2,6-dienoyl-CoA
C05280  cis,cis-3,6-Dodecadienoyl-CoA
C20683  Long-chain acyl-[acyl-carrier protein]
Reference
PMID:869535
  Authors
Parekh VR, Traxler RW, Sobek JM
  Title
N-Alkane oxidation enzymes of a pseudomonad.
  Journal
Appl Environ Microbiol 33:881-4 (1977)
DOI:10.1128/AEM.33.4.881-884.1977
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00061  Fatty acid biosynthesis
ko00062  Fatty acid elongation
ko00072  Synthesis and degradation of ketone bodies
ko00561  Glycerolipid metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00650  Butanoate metabolism
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