KEGG   PATHWAY: ko04810
Entry
ko04810                     Pathway                                
Name
Regulation of actin cytoskeleton
Class
Cellular Processes; Cell motility
Pathway map
ko04810  Regulation of actin cytoskeleton
ko04810

Other DBs
GO: 0030036
Orthology
K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
K00920  PIP4K2; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K02085  APC; adenomatosis polyposis coli protein
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02833  HRAS; GTPase HRas
K03099  SOS; son of sevenless
K03898  KNG, BK; kininogen
K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
K03915  BDKRB1; bradykinin receptor B1
K03916  BDKRB2; bradykinin receptor B2
K03994  C5; complement component 5
K03995  C6; complement component 6
K03996  C7; complement component 7
K03997  C8A; complement component 8 subunit alpha
K03998  C8B; complement component 8 subunit beta
K03999  C8G; complement component 8 subunit gamma
K04000  C9; complement component 9
K04129  CHRM1; muscarinic acetylcholine receptor M1
K04130  CHRM2; muscarinic acetylcholine receptor M2
K04131  CHRM3; muscarinic acetylcholine receptor M3
K04132  CHRM4; muscarinic acetylcholine receptor M4
K04133  CHRM5; muscarinic acetylcholine receptor M5
K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04357  EGF; epidermal growth factor
K04358  FGF; fibroblast growth factor
K04359  PDGFA; platelet-derived growth factor subunit A
K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367  MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04393  CDC42; cell division control protein 42
K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K04438  CRK, CRKII; C-crk adapter molecule crk
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04513  RHOA; Ras homolog gene family, member A
K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]
K04526  INS; insulin
K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
K05086  INSRR; insulin receptor-related receptor [EC:2.7.10.1]
K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K05450  PDGFC_D; platelet derived growth factor C/D
K05627  BAIAP2, IRSP53; BAI1-associated protein 2
K05692  ACTB_G1; actin beta/gamma 1
K05699  ACTN1_4; actinin alpha 1/4
K05700  VCL; vinculin
K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K05717  FN1; fibronectin 1
K05718  ITGAL, CD11a; integrin alpha L
K05719  ITGB1, CD29; integrin beta 1
K05720  FGD1; FYVE, RhoGEF and PH domain containing 1
K05722  FGD3; FYVE, RhoGEF and PH domain containing 3
K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
K05729  ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
K05730  VAV; guanine nucleotide exchange factor VAV
K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
K05732  ARHGAP35, GRLF1; glucocorticoid receptor DNA-binding factor 1
K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
K05734  PAK4; p21-activated kinase 4 [EC:2.7.11.1]
K05735  PAK6; p21-activated kinase 6 [EC:2.7.11.1]
K05736  PAK5, PAK7; p21-activated kinase 5 [EC:2.7.11.1]
K05737  GIT1; G protein-coupled receptor kinase interactor 1
K05740  DIAPH1; diaphanous 1
K05741  DIAPH2; diaphanous 2
K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
K05743  LIMK1; LIM domain kinase 1 [EC:2.7.11.1]
K05744  LIMK2; LIM domain kinase 2 [EC:2.7.11.1]
K05745  DIAPH3, DRF3; diaphanous 3
K05746  ENAH, MENA; enabled
K05748  WASF2; WAS protein family, member 2
K05749  CYFIP; cytoplasmic FMR1 interacting protein
K05750  NCKAP1, NAP125; NCK-associated protein 1
K05751  ABI2; abl interactor 2
K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
K05753  WASF1; WAS protein family, member 1
K05754  ARPC5; actin related protein 2/3 complex, subunit 5
K05755  ARPC4; actin related protein 2/3 complex, subunit 4
K05756  ARPC3; actin related protein 2/3 complex, subunit 3
K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758  ARPC2; actin related protein 2/3 complex, subunit 2
K05759  PFN; profilin
K05760  PXN; paxillin
K05762  RDX; radixin
K05763  MSN; moesin
K05764  TMSB4; thymosin, beta 4
K05765  CFL; cofilin
K05766  SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
K05767  IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3
K05768  GSN; gelsolin
K05769  ARHGEF4_29, ASEF1_2; Rho guanine nucleotide exchange factor 4/29
K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
K06461  ITGAM, CD11b; integrin alpha M
K06462  ITGAX, CD11c; integrin alpha X
K06464  ITGB2, CD18; integrin beta 2
K06476  ITGA2B, CD41; integrin alpha 2B
K06480  ITGA1, CD49a; integrin alpha 1
K06481  ITGA2, CD49b; integrin alpha 2
K06482  ITGA3, CD49c; integrin alpha 3
K06483  ITGA4, CD49d; integrin alpha 4
K06484  ITGA5, CD49e; integrin alpha 5
K06485  ITGA6, CD49f; integrin alpha 6
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06524  ITGAE, CD103; integrin alpha E
K06525  ITGB4, CD104; integrin beta 4
K06583  ITGA7; integrin alpha 7
K06584  ITGA8; integrin alpha 8
K06585  ITGA9; integrin alpha 9
K06586  ITGA10; integrin alpha 10
K06587  ITGA11; integrin alpha 11
K06588  ITGB5; integrin beta 5
K06589  ITGB6; integrin beta 6
K06590  ITGB7; integrin beta 7
K06591  ITGB8; integrin beta 8
K06594  ITGAD, CD11d; integrin alpha D
K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K07829  RRAS; Ras-related protein R-Ras
K07830  RRAS2, TC21; Ras-related protein R-Ras2
K07831  MRAS; Ras-related protein M-Ras
K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
K08007  EZR, VIL2; ezrin
K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K10031  CXCL12; C-X-C motif chemokine 12
K10351  MYL2; myosin regulatory light chain 2
K10352  MYH9s; myosin heavy chain 9/10/11/14
K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
K12753  MYL5; myosin regulatory light chain 5
K12754  MYL7; myosin regulatory light chain 7
K12755  MYL9; myosin regulatory light chain 9
K12756  MYL10; myosin regulatory light chain 10
K12757  MYL12; myosin regulatory light chain 12
K12758  MYLPF; fast skeletal myosin light chain 2
K13708  DOCK1; dedicator of cytokinesis protein 1
K13710  ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7
K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
K17260  ACTR2, ARP2; actin-related protein 2
K17386  PDGFB; platelet-derived growth factor subunit B
K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]
K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
K18496  FGF1; fibroblast growth factor 1
K18497  FGF2; fibroblast growth factor 2
K18584  ACTR3, ARP3; actin-related protein 3
K22428  FGF23; fibroblast growth factor 23
K22429  FGF21; fibroblast growth factor 21
K22603  FGF19; fibroblast growth factor 19
K23612  WASL; neural Wiskott-Aldrich syndrome protein
K26108  RGCC, RGC32; regulator of cell cycle RGCC
K27976  CYRI, FAM49; CYFIP-related Rac1 interactor
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ko04010  MAPK signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction

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