KEGG   PATHWAY: koe00230
Entry
koe00230                    Pathway                                
Name
Purine metabolism - Klebsiella michiganensis E718
Class
Metabolism; Nucleotide metabolism
Pathway map
koe00230  Purine metabolism
koe00230

Module
koe_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:koe00230]
koe_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:koe00230]
koe_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:koe00230]
koe_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:koe00230]
koe_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:koe00230]
Other DBs
GO: 0006163 0042278
Organism
Klebsiella michiganensis E718 [GN:koe]
Gene
A225_5045  ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
A225_5393  ADP compounds hydrolase NudE [KO:K08312] [EC:3.6.1.-]
A225_0768  Phosphopentomutase [KO:K01839] [EC:5.4.2.7]
A225_1711  Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
A225_5358  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
A225_3529  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
A225_4212  Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
A225_0263  Phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
A225_4344  Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
A225_3661  Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
A225_4407  Phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
A225_4343  Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
A225_1370  Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
A225_1371  Phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
A225_4329  Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
A225_2361  Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
A225_0264  IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
A225_1334  Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
A225_1345  UDP-sugar hydrolase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
A225_0636  5-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
A225_4660  5-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
A225_1694  Phosphatase NagD predicted to act in N-acetylglucosamine utilization subsystem [KO:K02566] [EC:3.1.3.5]
A225_5395  putative hydrolase [KO:K20881] [EC:3.1.3.-]
A225_1341  Inosine-guanosine kinase [KO:K00892] [EC:2.7.1.73]
A225_4269  Xanthosine phosphorylase [KO:K03783] [EC:2.4.2.1]
A225_0770  Purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
A225_1214  Cytoplasmic protein YaiE [KO:K09913] [EC:2.4.2.1 2.4.2.2]
A225_3409  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
A225_4445  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
A225_0937  Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
A225_4357  Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
A225_4373  Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
A225_0779  Inosine/xanthosine triphosphatase [KO:K01529] [EC:3.6.1.73]
A225_4983  Nucleoside 5-triphosphatase RdgB [KO:K01519] [EC:3.6.1.66]
A225_1067  Xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
A225_4284  Putative amidotransferase [KO:K01951] [EC:6.3.5.2]
A225_4356  GMP synthase [KO:K01951] [EC:6.3.5.2]
A225_2927  GMP synthase [KO:K01951] [EC:6.3.5.2]
A225_0907  GMP reductase [KO:K00364] [EC:1.7.1.7]
A225_2198  Guanine deaminase [KO:K01487] [EC:3.5.4.3]
A225_5670  Guanylate kinase [KO:K00942] [EC:2.7.4.8]
A225_4532  Ribonucleotide reductase of class Ib [KO:K00525] [EC:1.17.4.1]
A225_4127  Ribonucleotide reductase of class Ia [KO:K00525] [EC:1.17.4.1]
A225_4128  Ribonucleotide reductase of class Ia [KO:K00526] [EC:1.17.4.1]
A225_4533  Ribonucleotide reductase of class Ib [KO:K00526] [EC:1.17.4.1]
A225_0989  Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
A225_4183  Nucleotidase YfbR [KO:K08722] [EC:3.1.3.89]
A225_2374  hypothetical protein [KO:K06952] [EC:3.1.3.89]
A225_5672  GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
A225_0150  Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A225_4351  Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
A225_4693  GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
A225_0174  Adenylate cyclase [KO:K05851] [EC:4.6.1.1]
A225_0447  Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
A225_3264  Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
A225_3762  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
A225_4705  Decarboxylase family protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
A225_4004  Adenine deaminase [KO:K01486] [EC:3.5.4.2]
A225_0480  2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
A225_1339  Adenylate kinase [KO:K00939] [EC:2.7.4.3]
A225_4692  Nucleoside triphosphate pyrophosphohydrolase MazG [KO:K04765] [EC:3.6.1.9]
A225_0559  3',5'-cyclic-nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
A225_5043  3',5'-cyclic-nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
A225_0845  Bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
A225_4666  Adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
A225_4667  Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
A225_4668  Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
A225_2194  Salicylate hydroxylase [KO:K16839] [EC:1.14.13.113]
A225_3560  Transthyretin family protein [KO:K07127] [EC:3.5.2.17]
A225_2197  Transthyretin [KO:K07127] [EC:3.5.2.17]
A225_2196  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) decarboxylase [KO:K16840] [EC:4.1.1.97]
A225_2201  Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
A225_2202  putative polysaccharide deacetylase [KO:K16842] [EC:3.5.2.5]
A225_2214  N-carbamoyl-L-amino acid hydrolase [KO:K02083] [EC:3.5.3.9]
A225_2213  Serine-pyruvate aminotransferase [KO:K00839] [EC:2.6.1.112]
A225_5069  Urease alpha subunit [KO:K01428] [EC:3.5.1.5]
A225_5068  Urease beta subunit [KO:K01429] [EC:3.5.1.5]
A225_5067  Urease gamma subunit [KO:K01430] [EC:3.5.1.5]
A225_2204  Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit related amidase [KO:K22601] [EC:2.1.3.5]
A225_2207  Gamma-glutamyltranspeptidase [KO:K22602] [EC:3.5.1.126]
A225_3543  Carbamate kinase-like protein YqeA [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
koe00030  Pentose phosphate pathway
koe00220  Arginine biosynthesis
koe00250  Alanine, aspartate and glutamate metabolism
koe00260  Glycine, serine and threonine metabolism
koe00340  Histidine metabolism
koe00630  Glyoxylate and dicarboxylate metabolism
koe00730  Thiamine metabolism
koe00740  Riboflavin metabolism
koe00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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