KEGG   PATHWAY: leri00830
Entry
leri00830                   Pathway                                
Name
Retinol metabolism - Leucoraja erinacea (little skate)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
leri00830  Retinol metabolism
leri00830

Other DBs
GO: 0006776
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129705393  beta,beta-carotene 15,15'-dioxygenase-like [KO:K00515] [EC:1.13.11.63]
129700691  alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
129711452  short-chain dehydrogenase/reductase 3-like [KO:K11146] [EC:1.1.1.300]
129693396  dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
129698593  dehydrogenase/reductase SDR family member 9-like [KO:K11149] [EC:1.1.-.-]
129700765  zgc:109982; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
129714457  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
129696508  retinol dehydrogenase 10-like [KO:K11151] [EC:1.1.1.-]
129710141  retinol dehydrogenase 12-like isoform X1 [KO:K11153] [EC:1.1.1.300]
129700348  rdh12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
129699514  retinol dehydrogenase 13-like isoform X1 [KO:K11161] [EC:1.1.1.300]
129696040  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
129696283  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
129702629  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
129705196  diacylglycerol O-acyltransferase 1-like [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
129715600  dgat1a; diacylglycerol O-acyltransferase 1a isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
129714997  pnpla4; patatin-like phospholipase domain-containing protein 4 [KO:K11157] [EC:3.1.1.-]
129701008  retinoid isomerohydrolase-like [KO:K11158] [EC:3.1.1.64 5.3.3.22]
129695778  retinal dehydrogenase 2-like [KO:K07249] [EC:1.2.1.36]
129712514  aldh1a3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
129712640  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
129703905  cytochrome P450 26A1 isoform X1 [KO:K07437] [EC:1.14.14.-]
129701869  cytochrome P450 26B1-like [KO:K12664] [EC:1.14.14.-]
129715029  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
129703907  cytochrome P450 26C1-like [KO:K12665] [EC:1.14.14.-]
129714142  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
129714143  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
129713715  cytochrome P450 3A29-like [KO:K07424] [EC:1.14.14.1]
129706648  cytochrome P450 3A30-like [KO:K07424] [EC:1.14.14.1]
129706649  LOW QUALITY PROTEIN: cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
129705278  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129705279  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129705280  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129695342  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129698935  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129698936  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129698937  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129712786  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712787  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712788  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712789  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712791  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712792  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712795  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712796  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712797  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712799  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712800  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712802  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712803  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
129712804  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712805  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129712806  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
129710311  all-trans-retinol 13,14-reductase-like isoform X1 [KO:K09516] [EC:1.3.99.23]
129710319  si:ch1073-13h15.3; all-trans-retinol 13,14-reductase isoform X1 [KO:K09516] [EC:1.3.99.23]
129693907  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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