KEGG   PATHWAY: lroh03460
Entry
lroh03460                   Pathway                                
Name
Fanconi anemia pathway - Labeo rohita (rohu)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
lroh03460  Fanconi anemia pathway
lroh03460

Other DBs
GO: 0043240
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127152506  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
127153150  atrip; ATR-interacting protein [KO:K10905]
127153463  slx4; LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4 [KO:K10484]
127154292  her9; hairy-related 9 [KO:K06054]
127154338  wdr48b; WD repeat-containing protein 48 isoform X1 [KO:K15361]
127155327  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
127156025  wdr48a; WD repeat-containing protein 48a isoform X1 [KO:K15361]
127156115  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
127156574  fancf; Fanconi anemia group F protein [KO:K10893]
127156579  faap24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
127156771  fanci; Fanconi anemia group I protein isoform X1 [KO:K10895]
127161974  [KO:K10888]
127162339  cenpx; centromere protein X [KO:K15360]
127162981  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
127163113  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
127164899  fancg; Fanconi anemia group G protein isoform X1 [KO:K10894]
127164933  polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
127165992  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
127166044  poli; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
127166865  cenps; centromere protein S [KO:K11511]
127167254  fancd2; Fanconi anemia group D2 protein [KO:K10891]
127167326  usp1; ubiquitin carboxyl-terminal hydrolase 1 [KO:K11832] [EC:3.4.19.12]
127167473  her6; hairy-related 6 [KO:K06054]
127167556  poln; LOW QUALITY PROTEIN: DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
127168836  slx1b; structure-specific endonuclease subunit SLX1 isoform X1 [KO:K15078] [EC:3.6.1.-]
127168842  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
127169499  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
127169664  fancc; Fanconi anemia group C protein [KO:K10890]
127169987  fance; Fanconi anemia group E protein [KO:K10892]
127170686  rev1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
127171028  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
127171904  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
127172403  palb2; partner and localizer of BRCA2 [KO:K10897]
127173850  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
127174041  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
127174131  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
127174238  eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
127174792  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
127175149  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
127175320  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
127177532  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
127177582  brip1; LOW QUALITY PROTEIN: Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
127177612  brca2; breast cancer type 2 susceptibility protein [KO:K08775]
127178669  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
127179398  fancm; Fanconi anemia group M protein isoform X1 [KO:K10896]
127181226  blm; recQ-like DNA helicase BLM isoform X1 [KO:K10901] [EC:5.6.2.4]
127181230  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
127181619  rpa3; replication protein A 14 kDa subunit [KO:K10740]
127182489  rev3l; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
127183365  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
lroh03430  Mismatch repair
lroh03440  Homologous recombination
KO pathway
ko03460   

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