KEGG   PATHWAY: lroh03430
Entry
lroh03430                   Pathway                                
Name
Mismatch repair - Labeo rohita (rohu)
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
lroh03430  Mismatch repair
lroh03430

Other DBs
GO: 0006298
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127151948  pold3; DNA polymerase delta subunit 3 [KO:K03504]
127152964  rfc2; replication factor C subunit 2 [KO:K10755]
127154835  mlh3; DNA mismatch repair protein Mlh3 isoform X1 [KO:K08739]
127163511  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
127163737  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
127164802  msh3; DNA mismatch repair protein Msh3 [KO:K08736]
127166017  rfc5; replication factor C subunit 5 [KO:K10756]
127167069  pold4; DNA polymerase delta subunit 4 [KO:K03505]
127169233  pold2; DNA polymerase delta subunit 2 [KO:K02328]
127170648  rfc1; replication factor C subunit 1 isoform X1 [KO:K10754]
127171883  pcna; proliferating cell nuclear antigen [KO:K04802]
127172272  rfc3; replication factor C subunit 3 [KO:K10756]
127172878  rfc4; replication factor C subunit 4 [KO:K10755]
127173900  msh2; DNA mismatch repair protein Msh2 [KO:K08735]
127174131  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
127175257  msh6; DNA mismatch repair protein Msh6 [KO:K08737]
127175320  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
127177098  lig1; DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
127177532  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
127178669  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
127179345  exo1; exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
127181619  rpa3; replication protein A 14 kDa subunit [KO:K10740]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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