KEGG   PATHWAY: maua04260
Entry
maua04260                   Pathway                                
Name
Cardiac muscle contraction - Mesocricetus auratus (golden hamster)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
maua04260  Cardiac muscle contraction
maua04260

Other DBs
GO: 0060048
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101834428  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X23 [KO:K04850]
101825756  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
101830198  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101835763  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101838500  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101825511  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101836179  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
101844274  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101835530  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101827594  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X8 [KO:K04859]
101837712  Cacna2d3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101834159  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101838313  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101822817  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
101828143  Cacng3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
101838044  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101837781  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
101835632  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101835887  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101827881  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101841801  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
101826336  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X4 [KO:K00476] [EC:1.14.11.16]
101829540  Casq2; calsequestrin-2 isoform X1 [KO:K23445]
106023025  Trdn; triadin [KO:K23449]
101823693  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101841211  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101828431  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101824306  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101822799  Tnnc1; troponin C, slow skeletal and cardiac muscles isoform X3 [KO:K05865]
101830909  Tnni3; troponin I, cardiac muscle [KO:K12044]
101831759  Tnnt2; troponin T, cardiac muscle isoform X1 [KO:K12045]
101837255  Tpm1; tropomyosin alpha-1 chain isoform X7 [KO:K10373]
101831872  Tpm2; tropomyosin beta chain [KO:K10374]
101822952  Tpm3; tropomyosin alpha-3 chain isoform X7 [KO:K09290]
101836260  Tpm4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
101824839  Actc1; actin, alpha cardiac muscle 1 [KO:K12314]
101825281  myosin-6 isoform X1 [KO:K17751]
106022467  myosin-7 [KO:K17751]
101831072  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101830975  Myl3; myosin light chain 3 [KO:K12749]
101834801  Myl4; myosin light chain 4 [KO:K12750]
101839974  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
8457935  CYTB; cytochrome b [KO:K00412]
110339287  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101825065  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101834409  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101841714  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
121142591  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
121138131  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
101825739  cytochrome b-c1 complex subunit 7 [KO:K00417]
101834545  cytochrome b-c1 complex subunit 7-like [KO:K00417]
101822731  cytochrome b-c1 complex subunit 8 [KO:K00418]
101839373  cytochrome b-c1 complex subunit 9 [KO:K00419]
101830904  cytochrome b-c1 complex subunit 10 [KO:K00420]
8457929  COX3; cytochrome c oxidase subunit III [KO:K02262]
8457925  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
8457926  COX2; cytochrome c oxidase subunit II [KO:K02261]
101839655  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101844074  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101843749  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101834557  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101838803  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101833775  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101828586  cytochrome c oxidase subunit 6B2 isoform X2 [KO:K02267]
101836746  cytochrome c oxidase subunit 6B1 [KO:K02267]
101824143  cytochrome c oxidase subunit 6B1 [KO:K02267]
110341366  cytochrome c oxidase subunit 6C-2 isoform X1 [KO:K02268]
106021169  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-2 [KO:K02268]
101841805  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101843430  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101837612  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
101834758  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101829663  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101834067  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
121136920  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101827967  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
101832408  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101839273  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
101842252  Slc8a3; sodium/calcium exchanger 3 isoform X2 [KO:K05849]
101823918  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101828775  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
101829661  Slc9a7; sodium/hydrogen exchanger 7 isoform X1 [KO:K12041]
101838966  Slc9a6; sodium/hydrogen exchanger 6 isoform X1 [KO:K12041]
101828152  Atp1a3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
101828029  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
101844313  Atp1a2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101844581  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
101844422  Atp1b4; protein ATP1B4 [KO:K01540]
101828802  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101833660  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101836917  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
106021095  Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
101829817  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
maua04020  Calcium signaling pathway
KO pathway
ko04260   
LinkDB

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