KEGG   PATHWAY: mdo04530
Entry
mdo04530                    Pathway                                
Name
Tight junction - Monodelphis domestica (gray short-tailed opossum)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mdo04530  Tight junction
mdo04530

Other DBs
GO: 0005923
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100015309  CLDN7; claudin 7 [KO:K06087]
100022771  CLDN17; claudin 17 [KO:K06087]
100018944  CLDN4; claudin 4 [KO:K06087]
100032684  CLDN19; claudin 19 [KO:K06087]
100028537  CLDN2; claudin 2 [KO:K06087]
100014424  CLDN8; claudin 8 [KO:K06087]
100010701  CLDN16; claudin 16 [KO:K06087]
100014921  CLDN9; claudin 9 [KO:K06087]
100014960  CLDN6; claudin 6 [KO:K06087]
100027478  CLDN20; claudin 20 [KO:K06087]
100017552  CLDN5; claudin 5 [KO:K06087]
100010748  CLDN1; claudin 1 [KO:K06087]
100016738  CLDN15; claudin 15 [KO:K06087]
100012574  CLDN14; claudin 14 [KO:K06087]
100019024  CLDN23; claudin 23 [KO:K06087]
100019829  CLDN10; claudin 10 [KO:K06087]
100010018  CLDN11; claudin 11 [KO:K06087]
100016236  CLDN24; putative claudin-24 [KO:K06087]
100016275  CLDN22; claudin-22 [KO:K06087]
100016892  CLDN18; claudin 18 [KO:K06087]
100018879  CLDN3; claudin 3 [KO:K06087]
103096525  CLDN34; claudin 34 [KO:K06087]
100032182  CLDN25; claudin 25 [KO:K06087]
100021321  CLDN12; claudin 12 [KO:K06087]
103103995  claudin-16-like [KO:K06087]
100031291  OCLN; occludin [KO:K06088]
100014041  occludin-like [KO:K06088]
100032719  F11R; F11 receptor [KO:K06089]
100022671  JAM2; junctional adhesion molecule 2 [KO:K06735]
100022444  JAM3; junctional adhesion molecule 3 [KO:K06785]
100028158  BVES; blood vessel epicardial substance [KO:K21108]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100009767  cell division control protein 42 homolog [KO:K04393]
100022922  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
100021195  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
100017248  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
100023041  MPP5; membrane palmitoylated protein 5 [KO:K06091]
100017463  MPP4; membrane palmitoylated protein 4 [KO:K21109]
100017651  TJP3; tight junction protein 3 [KO:K06097]
100031754  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
100015950  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
100020001  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
100030202  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
100020306  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
103103873  mucin-16-like [KO:K18952] [EC:2.7.11.13]
100617582  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
100010646  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
100011594  AMOT; angiomotin [KO:K16819]
100013577  AMOTL1; angiomotin like 1 [KO:K06104]
100022998  AMOTL2; angiomotin like 2 [KO:K06104]
100014519  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100010877  merlin-like [KO:K16684]
100030761  NF2; neurofibromin 2 [KO:K16684]
100015630  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
100027295  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
100017371  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
100016936  SCRIB; scribbled planar cell polarity protein [KO:K16175]
100012652  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
100017519  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
100026516  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
100028805  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
100023749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
100014202  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
100018121  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
100023958  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100022889  PARD3; par-3 family cell polarity regulator [KO:K04237]
100015064  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
100021326  TJP1; tight junction protein 1 [KO:K05701]
100011017  TJAP1; tight junction associated protein 1 [KO:K06105]
100026349  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
100011645  DLG3; discs large MAGUK scaffold protein 3 [KO:K21098]
100020178  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
100022149  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
100018468  CGN; cingulin [KO:K06102]
100027620  CGNL1; cingulin like 1 [KO:K21110]
100617588  ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2 [KO:K12791]
100021110  RHOA; ras homolog family member A [KO:K04513]
100032686  GATA4; GATA binding protein 4 [KO:K09183]
100028927  MARVELD3; MARVEL domain containing 3 [KO:K21099]
103097444  MARVEL domain-containing protein 3-like [KO:K21099]
100032065  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100014119  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100019029  YBX3; Y-box-binding protein 3 [KO:K06099]
100010885  SYMPK; symplekin [KO:K06100]
100029293  PCNA; proliferating cell nuclear antigen [KO:K04802]
100013257  CCND1; cyclin D1 [KO:K04503]
100017172  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
100025525  RUNX1; runt related transcription factor 1 [KO:K08367]
100015971  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
100023596  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
100029635  ezrin [KO:K08007]
100032371  EZR; ezrin [KO:K08007]
100026658  RDX; radixin [KO:K05762]
100026721  MSN; moesin [KO:K05763]
100032210  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
100025924  ACTG1; actin gamma 1 [KO:K05692]
100029767  actin, cytoplasmic type 5 [KO:K05692]
100011313  actin, cytoplasmic 1 [KO:K05692]
100016601  actin, cytoplasmic 1-like [KO:K05692]
100020439  actin, cytoplasmic 1-like [KO:K05692]
100024060  actin, cytoplasmic 1-like [KO:K05692]
100028958  actin, cytoplasmic 1-like [KO:K05692]
103096124  actin, cytoplasmic 1-like [KO:K05692]
100011351  ACTB; actin beta [KO:K05692]
100014450  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100031527  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100026752  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100017081  CTTN; cortactin [KO:K06106]
100018057  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
100033310  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
100019380  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
100015343  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
100011720  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
100011761  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
100011642  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
100020355  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
100015059  actin-related protein 2/3 complex subunit 3 [KO:K05756]
103100567  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
100018488  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
100015743  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
100011538  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
100018699  WAS; Wiskott-Aldrich syndrome [KO:K05747]
103099139  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100032298  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100619852  RAB13; RAB13, member RAS oncogene family [KO:K06109]
100027283  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
100618269  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100032706  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100019715  MYL2; myosin light chain 2 [KO:K10351]
100014652  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
100022246  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
100019066  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
100013711  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
100014200  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
100013848  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
100018968  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
100011008  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
100032744  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
100012731  MYH10; myosin heavy chain 10 [KO:K10352]
100016741  MYH11; myosin heavy chain 11 [KO:K10352]
100024892  MYH9; myosin heavy chain 9 [KO:K10352]
100028971  MYL9; myosin light chain 9 [KO:K12755]
100012236  myosin regulatory light polypeptide 9 [KO:K12757]
100012278  MYL12B; myosin light chain 12B [KO:K12757]
100011484  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
103102537  SYNPO; synaptopodin [KO:K21112]
100010983  ACTN4; actinin alpha 4 [KO:K05699]
100023431  ACTN1; actinin alpha 1 [KO:K05699]
100028892  MICALL2; MICAL like 2 [KO:K21068]
100014326  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
100016883  RAB8B; RAB8B, member RAS oncogene family [KO:K07902]
100015023  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
100033128  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
100018342  ITGB1; integrin subunit beta 1 [KO:K05719]
100032641  AFDN; afadin, adherens junction formation factor [KO:K05702]
100021752  TJP2; tight junction protein 2 [KO:K06098]
100023159  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
100022678  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
100031321  MARVELD2; MARVEL domain containing 2 [KO:K17291]
100010238  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100010347  TUBA1B; tubulin alpha 1b [KO:K07374]
100010481  tubulin alpha-1D chain [KO:K07374]
100015203  tubulin alpha-8 chain [KO:K07374]
100022210  TUBA8; tubulin alpha 8 [KO:K07374]
100025645  TUBA3E; tubulin alpha 3e [KO:K07374]
100010436  TUBA1A; tubulin alpha-1 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mdo04520  Adherens junction
mdo04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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