KEGG   PATHWAY: mdo04810
Entry
mdo04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Monodelphis domestica (gray short-tailed opossum)
Class
Cellular Processes; Cell motility
Pathway map
mdo04810  Regulation of actin cytoskeleton
mdo04810

Other DBs
GO: 0030036
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100009723  FAM49A; family with sequence similarity 49 member A [KO:K27976]
100009767  [KO:K04393]
100010026  [KO:K05767]
100010071  F2R; coagulation factor II thrombin receptor [KO:K03914]
100010184  [KO:K04347]
100010264  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100010453  GNA12; G protein subunit alpha 12 [KO:K04346]
100010549  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
100010809  CFL2; cofilin 2 [KO:K05765]
100010978  VCL; vinculin [KO:K05700]
100010983  ACTN4; actinin alpha 4 [KO:K05699]
100011140  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100011261  PDGFD; platelet derived growth factor D [KO:K05450]
100011313  [KO:K05692]
100011351  ACTB; actin beta [KO:K05692]
100011642  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
100011680  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
100011720  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
100011744  DIAPH3; diaphanous related formin 3 [KO:K05745]
100011761  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
100011797  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
100011967  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
100012072  PFN2; profilin 2 [KO:K05759]
100012236  [KO:K12757]
100012278  MYL12B; myosin light chain 12B [KO:K12757]
100012317  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
100012499  FGF16; fibroblast growth factor 16 [KO:K04358]
100012692  FGF10; fibroblast growth factor 10 [KO:K04358]
100012727  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
100012731  MYH10; myosin heavy chain 10 [KO:K10352]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100013088  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100013112  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
100013564  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
100013566  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
100013592  APC; APC, WNT signaling pathway regulator [KO:K02085]
100013977  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
100014032  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
100014105  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100014118  FN1; fibronectin 1 [KO:K05717]
100014481  RGCC; regulator of cell cycle [KO:K26108]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100014690  FGF5; fibroblast growth factor 5 [KO:K04358]
100014692  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
100014852  ABI2; abl interactor 2 [KO:K05751]
100014893  ITGA10; integrin subunit alpha 10 [KO:K06586]
100015059  [KO:K05756]
100015064  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
100015312  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
100015343  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
100015350  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100015472  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100015572  C5; complement C5 [KO:K03994]
100015743  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
100015796  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
100015804  GSN; gelsolin [KO:K05768]
100015821  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
100015876  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100016207  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100016522  PFN1; profilin 1 [KO:K05759]
100016601  [KO:K05692]
100016607  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100016627  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100016706  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
100016741  MYH11; myosin heavy chain 11 [KO:K10352]
100016762  ITGAD; integrin alpha-D [KO:K06594]
100016794  ITGAX; integrin alpha-X [KO:K06462]
100016833  [KO:K06461]
100016871  ITGAM; integrin alpha-M [KO:K06461]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100016918  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
100017080  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
100017121  MRAS; muscle RAS oncogene homolog [KO:K07831]
100017126  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
100017140  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100017517  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100017537  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
100017615  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
100017790  ITGAL; integrin subunit alpha L [KO:K05718]
100017869  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
100017950  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100018236  C6; complement C6 [KO:K03995]
100018307  C7; complement C7 [KO:K03996]
100018336  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
100018342  ITGB1; integrin subunit beta 1 [KO:K05719]
100018376  ITGA6; integrin subunit alpha 6 [KO:K06485]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018488  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
100018731  ITGB8; integrin subunit beta 8 [KO:K06591]
100019108  C9; complement C9 [KO:K04000]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100019380  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
100019488  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
100019563  FGF6; fibroblast growth factor 6 [KO:K04358]
100019648  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
100019656  FGF23; fibroblast growth factor 23 [KO:K22428]
100019715  MYL2; myosin light chain 2 [KO:K10351]
100019731  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
100019816  ITGA9; integrin subunit alpha 9 [KO:K06585]
100019898  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
100019907  FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100020074  ITGB5; integrin subunit beta 5 [KO:K06588]
100020150  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
100020275  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100020355  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
100020414  NCKAP1; NCK associated protein 1 [KO:K05750]
100020439  [KO:K05692]
100020614  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
100020753  [KO:K13708]
100020785  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
100020951  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100021110  RHOA; ras homolog family member A [KO:K04513]
100021377  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100021575  FGF19; fibroblast growth factor 19 [KO:K22603]
100021631  FGF4; fibroblast growth factor 4 [KO:K04358]
100021692  FGF3; fibroblast growth factor 3 [KO:K04358]
100021835  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
100021885  FGF20; fibroblast growth factor 20 [KO:K04358]
100021927  DIAPH2; diaphanous related formin 2 [KO:K05741]
100022034  ITGB6; integrin subunit beta 6 [KO:K06589]
100022094  WASF1; WAS protein family member 1 [KO:K05753]
100022339  C8G; complement C8 gamma chain [KO:K03999]
100022489  ITGA3; integrin subunit alpha 3 [KO:K06482]
100022523  [KO:K07828]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100023197  FGF1; fibroblast growth factor 1 [KO:K18496]
100023287  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100023354  ITGA2B; integrin subunit alpha 2b [KO:K06476]
100023384  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
100023400  FGF8; fibroblast growth factor 8 [KO:K04358]
100023431  ACTN1; actinin alpha 1 [KO:K05699]
100023690  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
100023701  PDGFC; platelet derived growth factor C [KO:K05450]
100023763  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
100023928  FGF9; fibroblast growth factor 9 [KO:K04358]
100023962  BDKRB1; bradykinin receptor B1 [KO:K03915]
100023990  BDKRB2; bradykinin receptor B2 [KO:K03916]
100024057  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100024060  [KO:K05692]
100024494  PXN; paxillin [KO:K05760]
100024513  SPATA13; spermatogenesis associated 13 [KO:K05769]
100024566  GNA13; G protein subunit alpha 13 [KO:K04639]
100024596  ITGB2; integrin subunit beta 2 [KO:K06464]
100024639  FGF22; fibroblast growth factor 22 [KO:K04358]
100024747  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100024892  MYH9; myosin heavy chain 9 [KO:K10352]
100025096  [KO:K27976]
100025359  ITGB3; integrin subunit beta 3 [KO:K06493]
100025688  ENAH; enabled homolog (Drosophila) [KO:K05746]
100025727  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100025913  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
100025923  FGF7; fibroblast growth factor 7 [KO:K04358]
100025924  ACTG1; actin gamma 1 [KO:K05692]
100025947  ITGA11; integrin subunit alpha 11 [KO:K06587]
100026481  FAM49B; family with sequence similarity 49 member B [KO:K27976]
100026658  RDX; radixin [KO:K05762]
100026721  MSN; moesin [KO:K05763]
100026723  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100027090  ITGA8; integrin subunit alpha 8 [KO:K06584]
100027188  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100027264  ITGB4; integrin subunit beta 4 [KO:K06525]
100027358  MYL5; myosin light chain 5 [KO:K12753]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100027449  ITGA4; integrin subunit alpha 4 [KO:K06483]
100027799  DIAPH1; diaphanous related formin 1 [KO:K05740]
100027809  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
100028046  MYL10; myosin light chain 10 [KO:K12756]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100028127  ITGAV; integrin subunit alpha V [KO:K06487]
100028612  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
100028943  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100028958  [KO:K05692]
100028971  MYL9; myosin light chain 9 [KO:K12755]
100029055  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100029635  [KO:K08007]
100029767  [KO:K05692]
100029844  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
100029852  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100029873  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100029925  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100030012  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
100030063  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
100030115  MYL7; myosin light chain 7 [KO:K12754]
100030293  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
100030474  FGF17; fibroblast growth factor 17 [KO:K04358]
100030629  BAIAP2; BAI1 associated protein 2 [KO:K05627]
100030904  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
100031074  FGF18; fibroblast growth factor 18 [KO:K04358]
100031298  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
100031492  ITGA1; integrin subunit alpha 1 [KO:K06480]
100031498  ITGA2; integrin subunit alpha 2 [KO:K06481]
100031838  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100031959  PFN3; profilin 3 [KO:K05759]
100032214  C8B; complement C8 beta chain [KO:K03998]
100032221  C8A; complement C8 alpha chain [KO:K03997]
100032371  EZR; ezrin [KO:K08007]
100032488  ITGAE; integrin subunit alpha E [KO:K06524]
100032706  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100033279  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
100033310  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
100616829  SCIN; scinderin [KO:K05768]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100617751  [KO:K05764]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100618269  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100618879  WASF2; WAS protein family member 2 [KO:K05748]
100619033  [KO:K05764]
100619143  EGF; epidermal growth factor [KO:K04357]
100619824  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
103096124  [KO:K05692]
103097893  [KO:K26108]
103098619  [KO:K05767]
103100567  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
103102343  [KO:K05767]
103103071  KNG1; kininogen 1 [KO:K03898]
103103209  [KO:K04289]
107650459  PFN4; profilin family member 4 [KO:K05759]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mdo04010  MAPK signaling pathway
mdo04510  Focal adhesion
mdo04520  Adherens junction
KO pathway
ko04810   

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