KEGG   PATHWAY: mjv04142
Entry
mjv04142                    Pathway                                
Name
Lysosome - Manis javanica (Malayan pangolin)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mjv04142  Lysosome
mjv04142

Other DBs
GO: 0005764
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383553  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
108384042  AP1G1; AP-1 complex subunit gamma-1 isoform X2 [KO:K12391]
108384234  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
108384297  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
108384376  SCARB2; lysosome membrane protein 2 [KO:K12384]
108384552  PPT1; palmitoyl-protein thioesterase 1 isoform X2 [KO:K01074] [EC:3.1.2.22]
108384581  AP1M1; AP-1 complex subunit mu-1 isoform X2 [KO:K12393]
108385425  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
108385617  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
108386060  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
108386075  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
108386508  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
108386576  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
108386605  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
108386861  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
108387035  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
108387109  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
108387124  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
108387247  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
108387364  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
108387587  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
108388261  [KO:K01365] [EC:3.4.22.15]
108388645  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
108389217  HEXB; beta-hexosaminidase subunit beta isoform X2 [KO:K12373] [EC:3.2.1.52]
108390135  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
108390208  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
108390361  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
108390777  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
108391650  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
108391659  AP3S2; AP-3 complex subunit sigma-2 isoform X3 [KO:K12399]
108391707  GM2A; ganglioside GM2 activator [KO:K12383]
108391710  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
108392034  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
108392261  SPAM1; hyaluronidase PH-20 isoform X1 [KO:K01197] [EC:3.2.1.35]
108392404  ARSG; arylsulfatase G isoform X4 [KO:K12381] [EC:3.1.6.-]
108392581  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
108392610  [KO:K01319] [EC:3.4.21.20]
108392675  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
108392746  CTNS; cystinosin isoform X1 [KO:K12386]
108392765  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X2 [KO:K12404]
108392864  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
108392907  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
108393107  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
108393120  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
108393181  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
108393250  AP3D1; AP-3 complex subunit delta-1 isoform X2 [KO:K12396]
108393796  PPT2; lysosomal thioesterase PPT2 isoform X6 [KO:K01074] [EC:3.1.2.22]
108393855  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
108394894  NPC2; NPC intracellular cholesterol transporter 2 isoform X1 [KO:K13443]
108394955  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
108395291  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
108395793  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
108395927  CD63; CD63 antigen isoform X1 [KO:K06497]
108395956  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
108396117  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
108396143  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
108396459  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
108396511  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
108396906  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
108396952  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
108397548  CD164; sialomucin core protein 24 [KO:K06546]
108397851  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
108397925  NAPSA; napsin-A isoform X1 [KO:K08565] [EC:3.4.23.-]
108397994  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
108398111  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
108398253  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
108398416  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
108398504  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
108398556  [KO:K01365] [EC:3.4.22.15]
108398687  CLN5; bis(monoacylglycero)phosphate synthase CLN5 [KO:K12390]
108398765  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
108399197  SLC17A5; sialin isoform X1 [KO:K12301]
108399655  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
108399684  MCOLN1; mucolipin-1 [KO:K04992]
108399814  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c isoform X2 [KO:K02155]
108400192  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
108400322  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
108400453  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
108400474  SORT1; sortilin isoform X3 [KO:K12388]
108400648  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
108400816  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
108400842  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
108401337  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
108401452  NPC1; NPC intracellular cholesterol transporter 1 isoform X2 [KO:K12385]
108401554  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
108401979  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
108402199  CLTB; clathrin light chain B isoform X1 [KO:K04645]
108402487  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
108402603  PLA2G15; lysosomal phospholipase A and acyltransferase [KO:K06129] [EC:3.1.1.5]
108402744  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
108402857  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
108402859  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
108402860  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
108403782  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
108403999  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
108404026  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
108404184  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
108404268  CD68; macrosialin [KO:K06501]
108404396  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
108404450  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
108404643  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
108404831  [KO:K01365] [EC:3.4.22.15]
108404832  [KO:K01365] [EC:3.4.22.15]
108405236  CLTA; clathrin light chain A isoform X1 [KO:K04644]
108405651  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
108405827  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
108406262  PSAP; prosaposin isoform X1 [KO:K12382]
108406783  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
108406821  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
108406863  CLTCL1; LOW QUALITY PROTEIN: clathrin heavy chain 2 [KO:K04646]
108406901  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
108407286  GBA1; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
108407620  CLN3; battenin isoform X1 [KO:K12389]
108407879  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
108408097  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
108408258  ABCB9; ABC-type oligopeptide transporter ABCB9 isoform X1 [KO:K05656]
108408263  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
108408370  HGSNAT; LOW QUALITY PROTEIN: heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
108408940  GUSB; beta-glucuronidase isoform X2 [KO:K01195] [EC:3.2.1.31]
108409091  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
108410098  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
108410242  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mjv00511  Other glycan degradation
mjv00531  Glycosaminoglycan degradation
mjv04130  SNARE interactions in vesicular transport
mjv04140  Autophagy - animal
mjv04144  Endocytosis
KO pathway
ko04142   

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