KEGG   PATHWAY: mjv04140
Entry
mjv04140                    Pathway                                
Name
Autophagy - animal - Manis javanica (Malayan pangolin)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
mjv04140  Autophagy - animal
mjv04140

Other DBs
GO: 0006914
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383352  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
108383554  ATG4D; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108383587  GORASP2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797]
108384536  UBB; polyubiquitin-B [KO:K04551]
108384584  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
108384587  ATG4C; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
108384598  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
108384893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108384981  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
108385036  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108385119  [KO:K15464]
108385222  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108385635  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108386004  TSC1; hamartin isoform X1 [KO:K07206]
108386073  BECN1; beclin-1 isoform X1 [KO:K08334]
108386102  HMGB1; high mobility group protein B1 [KO:K10802]
108386346  WDFY3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
108387012  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
108387124  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
108387224  [KO:K07920]
108387268  RHEB; GTP-binding protein Rheb [KO:K07208]
108387302  [KO:K08803] [EC:2.7.11.1]
108387439  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108388079  [KO:K08341]
108388261  [KO:K01365] [EC:3.4.22.15]
108388881  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
108390198  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
108390300  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108390385  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108390526  ATG16L2; protein Atg16l2 isoform X1 [KO:K20868]
108390746  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108390826  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
108390909  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
108391072  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
108391258  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
108391259  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108391759  DDIT4; DNA damage-inducible transcript 4 protein isoform X2 [KO:K08270]
108391834  ATG9B; autophagy-related protein 9B isoform X1 [KO:K17907]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108392297  PRKCQ; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
108392402  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
108392501  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
108392801  DAPK2; death-associated protein kinase 2 isoform X2 [KO:K08803] [EC:2.7.11.1]
108392916  ATG3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
108393091  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108393161  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108393372  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
108393689  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
108393737  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108393784  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
108394028  [KO:K08516]
108394198  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
108394221  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108394413  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
108394585  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
108394615  NBR1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
108394633  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
108394972  EPG5; ectopic P granules protein 5 homolog [KO:K23883]
108395010  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
108395024  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
108395028  [KO:K08334]
108395032  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
108395177  ATG4A; cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
108395405  PRAP1; proline-rich acidic protein 1 [KO:K21250]
108395422  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
108395478  [KO:K23611]
108395582  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
108395807  OPTN; optineurin isoform X1 [KO:K19946]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108395952  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108395975  [KO:K02649]
108396087  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
108396226  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X2 [KO:K22991]
108396919  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
108396943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108397169  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108397189  IRS1; insulin receptor substrate 1 [KO:K16172]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108397772  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
108397938  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
108398047  NRAS; GTPase NRas [KO:K07828]
108398121  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
108398273  ATG101; autophagy-related protein 101 [KO:K19730]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108398502  VMP1; vacuole membrane protein 1 isoform X2 [KO:K21248]
108398556  [KO:K01365] [EC:3.4.22.15]
108398573  STX7; syntaxin-7 isoform X1 [KO:K08488]
108398691  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
108398806  [KO:K21245]
108399093  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
108399127  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108399180  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108399262  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108399379  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108399430  STK11; serine/threonine-protein kinase STK11 isoform X7 [KO:K07298] [EC:2.7.11.1]
108399477  STX17; syntaxin-17 [KO:K08491]
108399790  ATG4B; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
108399811  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
108400153  RRAGC; ras-related GTP-binding protein C [KO:K16186]
108400195  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
108400295  RRAS; ras-related protein R-Ras [KO:K07829]
108400357  RRAGD; ras-related GTP-binding protein D isoform X3 [KO:K16186]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108400975  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108401155  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108401175  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108401193  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
108401223  [KO:K08341]
108401642  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
108402364  CTSB; cathepsin B isoform X2 [KO:K01363] [EC:3.4.22.1]
108402501  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
108402614  INS; insulin [KO:K04526]
108403105  RAB39B; ras-related protein Rab-39B [KO:K07925]
108403107  RRAGA; ras-related GTP-binding protein A [KO:K16185]
108403230  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
108403280  [KO:K05087] [EC:2.7.10.1]
108403300  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
108403609  IGBP1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
108404186  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
108404246  RAB7A; ras-related protein Rab-7a [KO:K07897]
108404351  ATG16L1; autophagy-related protein 16-1 isoform X8 [KO:K17890]
108404396  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
108404522  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
108404831  [KO:K01365] [EC:3.4.22.15]
108404832  [KO:K01365] [EC:3.4.22.15]
108404942  [KO:K21246]
108405133  UVRAG; UV radiation resistance-associated gene protein [KO:K21249]
108405250  RAB1A; ras-related protein Rab-1A [KO:K07874]
108405345  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
108405893  [KO:K08512]
108405988  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108406016  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
108406080  [KO:K04382] [EC:3.1.3.16]
108406099  IRS4; insulin receptor substrate 4 [KO:K17446]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108406674  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108406809  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
108406920  [KO:K26797]
108406985  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
108407312  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X3 [KO:K17603]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108407974  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
108408223  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
108408298  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
108408316  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X3 [KO:K17908]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108408987  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
108409367  [KO:K17445]
108409843  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
108410066  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
108410254  TSC2; tuberin isoform X12 [KO:K07207]
108410297  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118966906  [KO:K08341]
118967030  [KO:K08516]
118967047  CTSV; cathepsin L2 isoform X1 [KO:K01365] [EC:3.4.22.15]
118967667  [KO:K02833]
118968429  [KO:K07920]
118968501  [KO:K15464]
118969212  [KO:K21246]
118971689  GORASP1; LOW QUALITY PROTEIN: Golgi reassembly-stacking protein 1 [KO:K26797]
118972014  [KO:K04382] [EC:3.1.3.16]
118972607  [KO:K23611]
118973997  [KO:K08341]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
mjv04010  MAPK signaling pathway
mjv04141  Protein processing in endoplasmic reticulum
mjv04142  Lysosome
mjv04150  mTOR signaling pathway
mjv04152  AMPK signaling pathway
mjv04910  Insulin signaling pathway
KO pathway
ko04140   

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