KEGG   PATHWAY: mlf04142
Entry
mlf04142                    Pathway                                
Name
Lysosome - Myotis lucifugus (little brown bat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mlf04142  Lysosome
mlf04142

Other DBs
GO: 0005764
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102417015  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
102417055  [KO:K12387]
102417556  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
102417614  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
102418013  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
102418099  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
102418158  CD63; CD63 antigen [KO:K06497]
102418793  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
102418809  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
102419050  ATP6V0A4; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
102419274  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
102419464  CTNS; cystinosin isoform X3 [KO:K12386]
102419898  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
102419980  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
102420099  TPP1; LOW QUALITY PROTEIN: tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
102420385  CLTA; clathrin light chain A isoform X1 [KO:K04644]
102420424  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2 [KO:K10087]
102420459  NAGLU; LOW QUALITY PROTEIN: alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
102421143  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
102421280  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102421494  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
102421744  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
102421760  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
102421816  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X2 [KO:K12404]
102421834  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
102421954  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
102422016  NAGA; LOW QUALITY PROTEIN: alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
102422075  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
102422095  FUCA1; tissue alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
102422819  HEXB; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
102422887  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
102423475  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
102423483  PSAP; prosaposin isoform X1 [KO:K12382]
102423485  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
102423523  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
102423752  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
102423857  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
102424014  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
102424280  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
102424432  NPC2; epididymal secretory protein E1 [KO:K13443]
102424559  TCIRG1; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
102424571  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
102424635  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
102424680  SUMF1; sulfatase-modifying factor 1 isoform X2 [KO:K13444] [EC:1.8.3.7]
102424885  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102425012  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
102425151  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
102425478  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X5 [KO:K12305] [EC:3.6.1.6]
102425580  GBA; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
102425837  AP3B2; AP-3 complex subunit beta-2 isoform X2 [KO:K12397]
102425856  GM2A; ganglioside GM2 activator isoform X1 [KO:K12383]
102425900  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
102426166  [KO:K02155]
102426302  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
102426506  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
102426649  [KO:K01365] [EC:3.4.22.15]
102426701  GAA; LOW QUALITY PROTEIN: lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
102426787  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
102427082  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
102427097  CD68; macrosialin isoform X1 [KO:K06501]
102427164  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
102427783  DMXL1; dmX-like protein 1 isoform X9 [KO:K24155]
102428630  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
102428724  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
102428922  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
102429438  AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402]
102429447  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528]
102429489  SLC17A5; sialin isoform X1 [KO:K12301]
102429506  [KO:K02155]
102429543  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102429657  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
102429849  CTSW; cathepsin W isoform X6 [KO:K08569] [EC:3.4.22.-]
102430111  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
102430553  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102431068  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
102431381  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
102431612  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
102431967  SCARB2; lysosome membrane protein 2 [KO:K12384]
102432064  AP1M2; LOW QUALITY PROTEIN: AP-1 complex subunit mu-2 [KO:K12393]
102433328  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
102433677  SORT1; sortilin isoform X1 [KO:K12388]
102434673  NPC1; Niemann-Pick C1 protein isoform X2 [KO:K12385]
102434740  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102434782  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102434826  AP4B1; AP-4 complex subunit beta-1 isoform X7 [KO:K12401]
102435006  [KO:K02154]
102435560  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
102435780  [KO:K01319] [EC:3.4.21.20]
102435833  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
102435909  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
102436272  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
102436364  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
102436533  CLN3; battenin [KO:K12389]
102436544  IGF2R; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
102436632  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
102437142  FUCA2; LOW QUALITY PROTEIN: plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
102437633  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
102437640  CD164; sialomucin core protein 24 [KO:K06546]
102437799  NAGPA; LOW QUALITY PROTEIN: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
102437952  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
102438139  AP1M1; AP-1 complex subunit mu-1 isoform X3 [KO:K12393]
102438684  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
102438982  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
102439100  AP3D1; LOW QUALITY PROTEIN: AP-3 complex subunit delta-1 [KO:K12396]
102439367  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
102439449  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
102439661  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
102440001  [KO:K01365] [EC:3.4.22.15]
102440059  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
102440123  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
102440262  TLDC1; TLD domain-containing protein 1 isoform X2 [KO:K27947]
102440269  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
102440366  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
102440408  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102440537  AP1G2; AP-1 complex subunit gamma-like 2 isoform X2 [KO:K12391]
102440594  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
102440779  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
102441095  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102441271  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
102441461  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
102441958  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
102442810  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102443065  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
102443203  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
111824700  [KO:K12403]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mlf00511  Other glycan degradation
mlf00531  Glycosaminoglycan degradation
mlf04130  SNARE interactions in vesicular transport
mlf04140  Autophagy - animal
mlf04144  Endocytosis
KO pathway
ko04142   

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