KEGG   PATHWAY: mmf04530
Entry
mmf04530                    Pathway                                
Name
Tight junction - Molossus molossus (Pallas's mastiff bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mmf04530  Tight junction
mmf04530

Other DBs
GO: 0005923
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118616086  CRB3; protein crumbs homolog 3 [KO:K06090]
118620520  CLDN12; claudin-12 [KO:K06087]
118617414  CLDN11; claudin-11 [KO:K06087]
118640086  CLDN5; claudin-5 [KO:K06087]
118617589  CLDN17; claudin-17 [KO:K06087]
118617780  CLDN14; claudin-14 [KO:K06087]
118617786  CLDN1; claudin-1 [KO:K06087]
118617815  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
118617831  CLDN8; claudin-8 [KO:K06087]
118633530  CLDN18; claudin-18 isoform X1 [KO:K06087]
118627255  CLDN19; claudin-19 [KO:K06087]
118634375  CLDN7; claudin-7 [KO:K06087]
118627754  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
118635579  CLDN34; claudin-34 [KO:K06087]
118641899  CLDN4; claudin-4 [KO:K06087]
118642252  CLDN15; claudin-15 [KO:K06087]
118642402  CLDN3; claudin-3 [KO:K06087]
118642416  CLDN6; claudin-6 [KO:K06087]
118642417  CLDN9; claudin-9 [KO:K06087]
118621285  CLDN20; claudin-20 [KO:K06087]
118636340  CLDN2; claudin-2 [KO:K06087]
118622755  CLDN23; claudin-23 [KO:K06087]
118622796  CLDN10; claudin-10 [KO:K06087]
118622921  putative claudin-24 [KO:K06087]
118623004  claudin-22-like [KO:K06087]
118641830  OCLN; occludin [KO:K06088]
118637330  F11R; junctional adhesion molecule A [KO:K06089]
118617379  JAM2; junctional adhesion molecule B [KO:K06735]
118639828  JAM3; junctional adhesion molecule C [KO:K06785]
118621583  BVES; blood vessel epicardial substance [KO:K21108]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118638912  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
118618742  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118619358  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118638707  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
118616403  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
118625426  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
118643665  TJP3; tight junction protein ZO-3 [KO:K06097]
118626678  PATJ; inaD-like protein [KO:K06092]
118629499  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
118643394  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118617164  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118635835  AMOT; angiomotin [KO:K16819]
118633312  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
118628189  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
118641433  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118639851  NF2; merlin isoform X1 [KO:K16684]
118641300  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
118634831  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
118617313  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
118643298  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
118622832  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118643693  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118627487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118638301  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118634735  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
118643480  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118615747  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118632198  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118616553  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118617355  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118640827  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
118621167  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
118627903  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
118636035  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
118630785  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118618257  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
118636944  CGN; cingulin [KO:K06102]
118642514  CGNL1; cingulin-like protein 1 [KO:K21110]
118637064  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118615702  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
118638258  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
118642468  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
118642157  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118615122  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118632456  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118627223  JUN; transcription factor AP-1 [KO:K04448]
118637527  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
118637719  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
118637720  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
118619948  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
118624208  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118636064  Y-box-binding protein 3-like [KO:K06099]
118636065  Y-box-binding protein 3-like [KO:K06099]
118624164  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
118638899  SYMPK; symplekin isoform X1 [KO:K06100]
118618985  PCNA; proliferating cell nuclear antigen isoform X1 [KO:K04802]
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118633888  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118616857  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
118644016  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
118634755  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
118620909  EZR; ezrin [KO:K08007]
118627915  RDX; radixin isoform X1 [KO:K05762]
118636343  MSN; moesin [KO:K05763]
118630650  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
118635031  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118616016  ACTB; actin, cytoplasmic 1 [KO:K05692]
118632910  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118620900  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118615560  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118617269  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
118643166  CTTN; src substrate cortactin [KO:K06106]
118630616  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
118620002  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
118624975  ACTR3; actin-related protein 3 [KO:K18584]
118641757  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
118641961  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
118635289  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2-like [KO:K05758]
118637223  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2-like [KO:K05758]
118625144  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
118640245  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
118615988  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
118633033  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
118635357  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
118629871  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
118637571  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
118640880  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
118635814  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
118638390  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
118626166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118615793  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118637514  RAB13; ras-related protein Rab-13 [KO:K06109]
118615592  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
118618764  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118630612  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118640015  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
118629701  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
118643522  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
118626404  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118641812  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118640238  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
118637324  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
118619752  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
118624156  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118625416  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
118641427  MYH11; myosin-11 isoform X1 [KO:K10352]
118635007  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
118623305  MYH9; myosin-9 [KO:K10352]
118638374  MYH14; myosin-14 [KO:K10352]
118623915  MYL6B; myosin light chain 6B [KO:K12751]
118623916  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
118631727  myosin light chain 6B-like [KO:K12751]
118619007  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118618154  myosin regulatory light chain 12B isoform X1 [KO:K12757]
118620838  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12757]
118617630  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
118633045  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118616105  SYNPO; synaptopodin isoform X1 [KO:K21112]
118626336  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
118638454  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
118616496  MICALL2; MICAL-like protein 2 [KO:K21068]
118615433  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
118616089  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
118643653  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
118637043  RAP1A; ras-related protein Rap-1A [KO:K04353]
118629439  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118621052  AFDN; afadin isoform X1 [KO:K05702]
118629764  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
118615237  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118642232  ras-related protein Rap-2c-like [KO:K07839]
118636362  RAP2C; ras-related protein Rap-2c [KO:K07839]
118641750  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
118640027  tubulin alpha-3 chain [KO:K07374]
118640348  tubulin alpha-3 chain-like [KO:K07374]
118623162  tubulin alpha-1C chain [KO:K07374]
118623544  TUBA8; tubulin alpha-8 chain [KO:K07374]
118623659  tubulin alpha-1B chain isoform X1 [KO:K07374]
118632190  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118616912  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
118625290  TUBA4A; tubulin alpha-4A chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mmf04520  Adherens junction
mmf04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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