KEGG   PATHWAY: mmu00983
Entry
mmu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Mus musculus (house mouse)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmu00983  Drug metabolism - other enzymes
mmu00983

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100042295  Gsta13; glutathione S-transferase alpha 13 [KO:K00799] [EC:2.5.1.18]
100042314  Gsta5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
100042625  Gstp-ps; glutathione S-transferase, pi, pseudogene [KO:K23790]
100559  Ugt2b38; UDP glucuronosyltransferase 2 family, polypeptide B38 [KO:K00699] [EC:2.4.1.17]
100727  Ugt2b34; UDP glucuronosyltransferase 2 family, polypeptide B34 [KO:K00699] [EC:2.4.1.17]
103140  Gstt3; glutathione S-transferase, theta 3 [KO:K00799] [EC:2.5.1.18]
103149  Upb1; ureidopropionase, beta [KO:K01431] [EC:3.5.1.6]
104158  Ces1d; carboxylesterase 1D [KO:K01044] [EC:3.1.1.1]
110006  Gusb; glucuronidase, beta [KO:K01195] [EC:3.2.1.31]
110074  Dut; deoxyuridine triphosphatase [KO:K01520] [EC:3.6.1.23]
112417  Ugt2b37; UDP glucuronosyltransferase 2 family, polypeptide B37 [KO:K00699] [EC:2.4.1.17]
12623  Ces1g; carboxylesterase 1G [KO:K01044] [EC:3.1.1.1]
13106  Cyp2e1; cytochrome P450, family 2, subfamily e, polypeptide 1 [KO:K07415] [EC:1.14.14.-]
13884  Ces1c; carboxylesterase 1C [KO:K01044] [EC:3.1.1.1]
13897  Ces1e; carboxylesterase 1E [KO:K01044] [EC:3.1.1.1]
139907708  Nme1-nme2; Nme1-Nme2 readthrough [KO:K00940] [EC:2.7.4.6]
14857  Gsta1; glutathione S-transferase, alpha 1 (Ya) [KO:K00799] [EC:2.5.1.18]
14858  Gsta2; glutathione S-transferase, alpha 2 (Yc2) [KO:K00799] [EC:2.5.1.18]
14859  Gsta3; glutathione S-transferase, alpha 3 [KO:K00799] [EC:2.5.1.18]
14860  Gsta4; glutathione S-transferase, alpha 4 [KO:K00799] [EC:2.5.1.18]
14862  Gstm1; glutathione S-transferase, mu 1 [KO:K00799] [EC:2.5.1.18]
14863  Gstm2; glutathione S-transferase, mu 2 [KO:K00799] [EC:2.5.1.18]
14864  Gstm3; glutathione S-transferase, mu 3 [KO:K00799] [EC:2.5.1.18]
14865  Gstm4; glutathione S-transferase, mu 4 [KO:K00799] [EC:2.5.1.18]
14866  Gstm5; glutathione S-transferase, mu 5 [KO:K00799] [EC:2.5.1.18]
14867  Gstm6; glutathione S-transferase, mu 6 [KO:K00799] [EC:2.5.1.18]
14869  Gstp2; glutathione S-transferase, pi 2 [KO:K23790]
14870  Gstp1; glutathione S-transferase, pi 1 [KO:K23790]
14871  Gstt1; glutathione S-transferase, theta 1 [KO:K00799] [EC:2.5.1.18]
14872  Gstt2; glutathione S-transferase, theta 2 [KO:K00799] [EC:2.5.1.18]
14873  Gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
15452  Hprt1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
16434  Itpa; inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [KO:K01519] [EC:3.6.1.66]
171567  Nme7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
17523  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
17960  Nat1; N-acetyl transferase 1 [KO:K00622] [EC:2.3.1.5]
17961  Nat2; N-acetyltransferase 2 (arylamine N-acetyltransferase) [KO:K00622] [EC:2.3.1.5]
17962  Nat3; N-acetyltransferase 3 [KO:K00622] [EC:2.3.1.5]
18102  Nme1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
18103  Nme2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
20133  Rrm1; ribonucleotide reductase M1 [KO:K10807] [EC:1.17.4.1]
20135  Rrm2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
211666  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
21877  Tk1; thymidine kinase 1 [KO:K00857] [EC:2.7.1.21]
22017  Tpmt; thiopurine methyltransferase [KO:K00569] [EC:2.1.1.67]
22236  Ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
22238  Ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
22245  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
22247  Umps; uridine monophosphate synthetase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
22271  Upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
22436  Xdh; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
225884  Gstp3; glutathione S-transferase pi 3 [KO:K23790]
229363  Gmps; guanine monophosphate synthetase [KO:K01951] [EC:6.3.5.2]
231396  Ugt2b36; UDP glucuronosyltransferase 2 family, polypeptide B36 [KO:K00699] [EC:2.4.1.17]
234564  Ces1f; carboxylesterase 1F [KO:K01044] [EC:3.1.1.1]
234669  Ces2b; carboxyesterase 2B [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
234671  Ces2c; carboxylesterase 2C [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
234673  Ces2e; carboxylesterase 2E [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
23917  Impdh1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
23918  Impdh2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
243085  Ugt2b35; UDP glucuronosyltransferase 2 family, polypeptide B35 [KO:K00699] [EC:2.4.1.17]
244595  Ces1a; carboxylesterase 1A [KO:K01044] [EC:3.1.1.1]
382044  Ces1b; carboxylesterase 1B [KO:K01044] [EC:3.1.1.1]
382985  Rrm2b; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
394430  Ugt1a10; UDP glycosyltransferase 1 family, polypeptide A10 [KO:K00699] [EC:2.4.1.17]
394432  Ugt1a7c; UDP glucuronosyltransferase 1 family, polypeptide A7C [KO:K00699] [EC:2.4.1.17]
394433  Ugt1a5; UDP glucuronosyltransferase 1 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
394434  Ugt1a9; UDP glucuronosyltransferase 1 family, polypeptide A9 [KO:K00699] [EC:2.4.1.17]
394435  Ugt1a6b; UDP glucuronosyltransferase 1 family, polypeptide A6B [KO:K00699] [EC:2.4.1.17]
394436  Ugt1a1; UDP glucuronosyltransferase 1 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
436059  Ces2h; carboxylesterase 2H [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
54369  Nme6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
552899  Ugt2a2; UDP glucuronosyltransferase 2 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
56520  Nme4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
56615  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
57813  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
613123  Ugt1a8; UDP glucuronosyltransferase 1 family, polypeptide A8 [KO:K00699] [EC:2.4.1.17]
64705  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
66447  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
66588  Cmpk1; cytidine/uridine monophosphate kinase 1 [KO:K13800] [EC:2.7.4.14]
68214  Gsto2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
68312  Gstm7; glutathione S-transferase, mu 7 [KO:K00799] [EC:2.5.1.18]
68556  Uckl1; uridine-cytidine kinase 1-like 1 [KO:K00876] [EC:2.7.1.48]
71773  Ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 [KO:K00699] [EC:2.4.1.17]
72094  Ugt2a3; UDP glucuronosyltransferase 2 family, polypeptide A3 [KO:K00699] [EC:2.4.1.17]
72269  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
72361  Ces2g; carboxylesterase 2G [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
72962  Tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
75704  Ces1h; carboxylesterase 1H [KO:K01044] [EC:3.1.1.1]
75886  Gstt4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
76654  Upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
79059  Nme3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
80914  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
94215  Ugt2a1; UDP glucuronosyltransferase 2 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
94284  Ugt1a6a; UDP glucuronosyltransferase 1 family, polypeptide A6A [KO:K00699] [EC:2.4.1.17]
99586  Dpyd; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   

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