KEGG   PATHWAY: npd04914
Entry
npd04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Nothoprocta perdicaria (Chilean tinamou)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
npd04914  Progesterone-mediated oocyte maturation
npd04914

Other DBs
GO: 0001556
Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942696  [KO:K02649]
112942706  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112942883  CCNA1; cyclin-A1 [KO:K06627]
112942965  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
112943722  PGR; progesterone receptor [KO:K08556]
112943951  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112944417  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112944572  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112944957  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112945237  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112945254  INS; insulin [KO:K04526]
112945268  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
112945628  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112945875  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
112945881  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112946016  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
112946238  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112946628  IGF1; insulin-like growth factor I [KO:K05459]
112946780  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
112947033  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
112947911  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112948263  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112948275  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112948757  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112948774  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112948786  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
112948967  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112949781  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
112950179  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
112950229  CCNA2; cyclin-A2 [KO:K06627]
112950312  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112950524  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112950669  KRAS; GTPase KRas [KO:K07827]
112950735  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
112951272  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
112951353  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
112951558  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
112951968  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112952219  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
112952569  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112952690  FZR1; fizzy-related protein homolog [KO:K03364]
112952794  CDC23; cell division cycle protein 23 homolog [KO:K03355]
112952880  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
112952895  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
112953017  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112953204  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
112953610  CDC16; cell division cycle protein 16 homolog [KO:K03353]
112954087  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
112954316  STK10; serine/threonine-protein kinase 10 isoform X1 [KO:K08837] [EC:2.7.11.1]
112954488  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
112954523  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112954821  SPDYA; speedy protein A [KO:K08694]
112955254  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112955351  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955491  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955546  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
112955595  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112955683  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112956016  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
112956123  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
112956827  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112956927  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112957612  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
112958156  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112958374  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
112958518  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
112959234  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112959267  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112959414  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112959569  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
112959596  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112959724  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112959727  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112959824  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
112959937  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
112960094  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112960219  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
112960385  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
npd04010  MAPK signaling pathway
npd04110  Cell cycle
KO pathway
ko04914   

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