KEGG   PATHWAY: npd04010
Entry
npd04010                    Pathway                                
Name
MAPK signaling pathway - Nothoprocta perdicaria (Chilean tinamou)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
npd04010  MAPK signaling pathway
npd04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942328  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112942340  NTF3; neurotrophin-3 [KO:K04356]
112942456  [KO:K16342] [EC:3.1.1.4]
112942457  [KO:K16342] [EC:3.1.1.4]
112942458  [KO:K16342] [EC:3.1.1.4]
112942459  [KO:K16342] [EC:3.1.1.4]
112942468  [KO:K16342] [EC:3.1.1.4]
112942469  [KO:K16342] [EC:3.1.1.4]
112942485  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
112942489  [KO:K16342] [EC:3.1.1.4]
112942493  [KO:K16342] [EC:3.1.1.4]
112942494  [KO:K16342] [EC:3.1.1.4]
112942568  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112942594  FGF20; fibroblast growth factor 20 [KO:K04358]
112942609  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
112942612  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112942654  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
112942759  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
112942772  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112942799  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
112942902  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112942995  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
112943150  ANGPT2; angiopoietin-2 [KO:K05466]
112943376  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112943501  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112943529  HRAS; GTPase HRas [KO:K02833]
112943557  JUN; transcription factor AP-1 [KO:K04448]
112943563  FGF3; fibroblast growth factor 3 [KO:K04358]
112943564  FGF4; fibroblast growth factor 4 [KO:K04358]
112943565  FGF19; fibroblast growth factor 19 [KO:K22603]
112943569  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112943669  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
112943851  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
112944010  VEGFD; vascular endothelial growth factor D [KO:K05449]
112944294  FGF18; fibroblast growth factor 18 [KO:K04358]
112944427  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112944556  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
112944571  RAP1A; ras-related protein Rap-1A [KO:K04353]
112944579  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
112944601  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
112944889  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112945067  [KO:K05126] [EC:2.7.10.1]
112945238  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112945240  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112945254  INS; insulin [KO:K04526]
112945343  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
112945540  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112945554  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112945566  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112945604  RASA1; ras GTPase-activating protein 1 [KO:K04352]
112945605  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
112945628  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112945646  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
112945862  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
112945911  CRKL; crk-like protein [KO:K04438]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112946238  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112946293  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
112946348  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
112946444  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112946463  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112946540  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112946628  IGF1; insulin-like growth factor I [KO:K05459]
112946696  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
112946735  FGF10; fibroblast growth factor 10 [KO:K04358]
112946786  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
112946815  EFNA2; ephrin-A2 [KO:K05462]
112946830  FGF22; fibroblast growth factor 22 [KO:K04358]
112946960  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
112947066  [KO:K05096] [EC:2.7.10.1]
112947111  FGF16; fibroblast growth factor 16 [KO:K04358]
112947361  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112947678  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112947715  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112947750  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112947758  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112947886  RASA2; ras GTPase-activating protein 2 [KO:K08053]
112948263  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112948275  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112948319  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
112948337  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112948431  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112948549  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
112948705  EFNA5; ephrin-A5 [KO:K05462]
112948774  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112948838  BDNF; brain-derived neurotrophic factor [KO:K04355]
112948967  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112949026  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112949046  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
112949082  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112949086  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
112949088  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112949117  [KO:K25414]
112949140  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
112949171  ARRB1; beta-arrestin-1 [KO:K04439]
112949231  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112949314  PDGFC; platelet-derived growth factor C [KO:K05450]
112949385  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
112949549  ANGPT4; angiopoietin-4 [KO:K05467]
112949613  STK4; serine/threonine-protein kinase 4 [KO:K04411]
112949776  TGFA; protransforming growth factor alpha [KO:K08774]
112950060  AREG; amphiregulin [KO:K09782]
112950071  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
112950082  EREG; proepiregulin [KO:K09784]
112950102  FGF5; fibroblast growth factor 5 [KO:K04358]
112950113  FGF9; fibroblast growth factor 9 [KO:K04358]
112950166  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
112950246  FGF2; fibroblast growth factor 2 [KO:K18497]
112950309  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112950313  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
112950393  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
112950459  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
112950535  IL1B; interleukin-1 beta [KO:K04519]
112950558  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
112950669  KRAS; GTPase KRas [KO:K07827]
112950735  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
112950838  [KO:K03283]
112950846  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
112950901  STMN1; stathmin [KO:K04381]
112951091  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112951109  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
112951177  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112951360  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
112951449  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
112951487  NRAS; GTPase NRas [KO:K07828]
112951503  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
112951551  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
112951648  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112951854  PDGFD; platelet-derived growth factor D [KO:K05450]
112951950  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
112951968  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112951995  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112952459  MECOM; MDS1 and EVI1 complex locus protein [KO:K04462] [EC:2.1.1.367]
112952527  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
112952603  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
112952606  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112952766  FGF1; fibroblast growth factor 1 [KO:K18496]
112952820  FGF7; fibroblast growth factor 7 [KO:K04358]
112952898  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
112952906  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112952924  [KO:K04358]
112952990  EFNA1; ephrin-A1 [KO:K05462]
112952991  EFNA3; ephrin-A3 [KO:K05462]
112952992  EFNA4; ephrin-A4 [KO:K05462]
112953017  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112953042  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
112953054  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
112953071  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112953115  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112953156  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112953216  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
112953405  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
112953442  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112953544  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112953650  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
112953655  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112953666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112953760  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112953764  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
112953766  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112953768  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112953853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112953948  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
112954044  MAX; protein max [KO:K04453]
112954270  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112954304  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112954364  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112954421  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112954502  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
112954523  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112954570  CRK; adapter molecule crk isoform X1 [KO:K04438]
112954593  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
112954606  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112954636  NF1; neurofibromin [KO:K08052]
112954904  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
112954963  [KO:K04388] [EC:2.7.11.30]
112954964  [KO:K04386]
112955051  FGF23; fibroblast growth factor 23 [KO:K22428]
112955103  SRF; serum response factor isoform X1 [KO:K04378]
112955150  TGFB2; transforming growth factor beta-2 [KO:K13376]
112955177  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
112955244  SOS1; son of sevenless homolog 1 [KO:K03099]
112955351  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955469  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112955491  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955546  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
112955797  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112956027  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112956232  KITLG; kit ligand [KO:K05461]
112956250  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
112956313  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
112956318  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112956500  STK3; serine/threonine-protein kinase 3 [KO:K04412]
112956720  HSPB1; heat shock protein beta-1 [KO:K04455]
112956756  [KO:K04437]
112956803  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112956827  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112956891  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112956917  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
112957075  DUSP5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112957077  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112957093  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
112957145  FGF8; fibroblast growth factor 8 [KO:K04358]
112957256  EGF; pro-epidermal growth factor [KO:K04357]
112957292  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112957312  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112957315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112957357  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112957523  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112957536  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
112957684  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112957695  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112957763  SOS2; son of sevenless homolog 2 [KO:K03099]
112957867  ANGPT1; angiopoietin-1 [KO:K05465]
112957980  FOS; proto-oncogene c-Fos [KO:K04379]
112958022  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
112958057  PGF; placenta growth factor [KO:K05448]
112958059  [KO:K16859]
112958062  TGFB3; transforming growth factor beta-3 [KO:K13377]
112958101  [KO:K04421] [EC:2.7.11.25]
112958106  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112958156  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112958220  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
112958230  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
112958338  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
112958373  HGF; hepatocyte growth factor [KO:K05460]
112958375  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
112958443  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
112958862  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
112958867  RAP1B; ras-related protein Rap-1b [KO:K07836]
112959118  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
112959119  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112959180  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
112959234  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112959267  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112959347  [KO:K17534] [EC:2.7.11.25]
112959394  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
112959404  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112959411  ARTN; artemin [KO:K25415]
112959422  MYC; myc proto-oncogene protein [KO:K04377]
112959540  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112959662  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
112959724  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112959727  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112959749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
112959759  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112959825  MRAS; ras-related protein M-Ras [KO:K07831]
112959834  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
112959872  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
112959897  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112959945  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
112960040  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112960066  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
112960203  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
112960209  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
112960230  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
112960247  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
112960385  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
npd04070  Phosphatidylinositol signaling system
npd04110  Cell cycle
npd04115  p53 signaling pathway
npd04210  Apoptosis
npd04310  Wnt signaling pathway
KO pathway
ko04010   

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