KEGG   PATHWAY: npm00260
Entry
npm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Neorhizobium petrolearium
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
npm00260  Glycine, serine and threonine metabolism
npm00260

Module
npm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:npm00260]
npm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:npm00260]
npm_M00555  Betaine biosynthesis, choline => betaine [PATH:npm00260]
npm_M00621  Glycine cleavage system [PATH:npm00260]
npm_M00919  Ectoine degradation, ectoine => aspartate [PATH:npm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Neorhizobium petrolearium [GN:npm]
Gene
QEO92_20355  aspartate kinase [KO:K00928] [EC:2.7.2.4]
QEO92_23450  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QEO92_08460  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QEO92_02920  homoserine kinase [KO:K02204] [EC:2.7.1.39]
QEO92_02990  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QEO92_16795  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
QEO92_05320  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QEO92_00495  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
QEO92_25895  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
QEO92_29840  glycerate kinase [KO:K11529] [EC:2.7.1.165]
QEO92_25840  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
QEO92_16280  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QEO92_22295  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QEO92_16285  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
QEO92_10875  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
QEO92_15095  alcohol dehydrogenase catalytic domain-containing protein [KO:K00060] [EC:1.1.1.103]
QEO92_21150  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
QEO92_10315  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
QEO92_10305  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
QEO92_08780  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QEO92_16175  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QEO92_21315  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QEO92_10310  gcvH; glycine cleavage system protein GcvH [KO:K02437]
QEO92_04760  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
QEO92_03320  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
QEO92_03325  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
QEO92_02555  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
QEO92_10585  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
QEO92_17020  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
QEO92_17030  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
QEO92_17015  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
QEO92_17025  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
QEO92_10145  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
QEO92_07720  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
QEO92_12915  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
QEO92_19415  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
QEO92_22025  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
QEO92_26745  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
QEO92_23685  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
QEO92_23680  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
QEO92_19405  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
QEO92_06315  M14 family metallopeptidase [KO:K15784] [EC:3.5.1.125]
QEO92_19400  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
QEO92_19460  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
QEO92_19455  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
npm00010  Glycolysis / Gluconeogenesis
npm00020  Citrate cycle (TCA cycle)
npm00230  Purine metabolism
npm00250  Alanine, aspartate and glutamate metabolism
npm00270  Cysteine and methionine metabolism
npm00290  Valine, leucine and isoleucine biosynthesis
npm00300  Lysine biosynthesis
npm00330  Arginine and proline metabolism
npm00460  Cyanoamino acid metabolism
npm00470  D-Amino acid metabolism
npm00564  Glycerophospholipid metabolism
npm00600  Sphingolipid metabolism
npm00620  Pyruvate metabolism
npm00630  Glyoxylate and dicarboxylate metabolism
npm00640  Propanoate metabolism
npm00680  Methane metabolism
npm00860  Porphyrin metabolism
npm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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