KEGG   PATHWAY: oaa00564
Entry
oaa00564                    Pathway                                
Name
Glycerophospholipid metabolism - Ornithorhynchus anatinus (platypus)
Class
Metabolism; Lipid metabolism
Pathway map
oaa00564  Glycerophospholipid metabolism
oaa00564

Module
oaa_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:oaa00564]
oaa_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:oaa00564]
oaa_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:oaa00564]
Other DBs
GO: 0006650
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073354  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
100073500  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
100073704  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
100073865  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
100073869  [KO:K01047] [EC:3.1.1.4]
100074602  PLPP5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100074850  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100075037  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
100075335  SAMD8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
100075425  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
100075836  [KO:K01047] [EC:3.1.1.4]
100075837  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
100076271  DGKH; diacylglycerol kinase eta isoform X5 [KO:K00901] [EC:2.7.1.107]
100076775  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
100077162  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100077278  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100077303  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
100077586  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
100077991  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
100078001  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100078355  SELENOI; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
100078529  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100078592  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100079134  LCLAT1; LOW QUALITY PROTEIN: lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100079251  [KO:K01047] [EC:3.1.1.4]
100079264  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
100079499  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100079561  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
100079865  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
100080547  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
100080945  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
100081113  [KO:K01047] [EC:3.1.1.4]
100081323  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100081433  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
100081509  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
100081592  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
100082289  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
100082465  DGKI; diacylglycerol kinase iota isoform X2 [KO:K00901] [EC:2.7.1.107]
100082802  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
100083157  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100083365  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
100083387  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100083525  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
100083805  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X2 [KO:K18695] [EC:3.1.4.2]
100083897  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
100083997  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
100084239  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
100084258  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
100084285  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
100084397  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
100084434  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100084563  [KO:K00993] [EC:2.7.8.1]
100084689  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
100084970  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
100085042  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
100085374  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
100085458  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100085500  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
100085563  [KO:K16342] [EC:3.1.1.4]
100085793  PLD4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
100085954  GPD1; LOW QUALITY PROTEIN: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
100085985  GDPD5; glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1 [KO:K28873]
100086059  TAZ; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
100086135  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100086783  [KO:K16342] [EC:3.1.1.4]
100087110  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
100087239  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
100087731  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100087743  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
100087758  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
100087817  ACHE; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
100088140  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
100088367  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
100088450  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100088466  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100088576  MBOAT7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
100088896  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
100089049  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
100089235  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
100089349  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
100089526  ADPRM; LOW QUALITY PROTEIN: manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100089778  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
100090109  [KO:K01080] [EC:3.1.3.4]
100090638  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
100091692  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
100091845  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
100092529  [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100092678  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100093422  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
100093495  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
100681539  [KO:K01047] [EC:3.1.1.4]
100681775  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103165327  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
103166456  [KO:K01047] [EC:3.1.1.4]
103166516  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
103166923  [KO:K13618] [EC:3.1.1.111]
103167872  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
103169305  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
103170804  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114805419  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
114808829  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
114809084  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114809128  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
114809961  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
114812189  [KO:K01047] [EC:3.1.1.4]
114812284  [KO:K01047] [EC:3.1.1.4]
114813849  [KO:K00006] [EC:1.1.1.8]
114816901  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
114818237  [KO:K01047] [EC:3.1.1.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
oaa00010  Glycolysis / Gluconeogenesis
oaa00260  Glycine, serine and threonine metabolism
oaa00561  Glycerolipid metabolism
oaa00562  Inositol phosphate metabolism
oaa00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
oaa00565  Ether lipid metabolism
oaa00620  Pyruvate metabolism
KO pathway
ko00564   

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