KEGG   PATHWAY: oas04612
Entry
oas04612                    Pathway                                
Name
Antigen processing and presentation - Ovis aries (sheep)
Class
Organismal Systems; Immune system
Pathway map
oas04612  Antigen processing and presentation
oas04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Ovis aries (sheep) [GN:oas]
Gene
443396  IFNG; interferon gamma precursor [KO:K04687]
443540  TNF; tumor necrosis factor [KO:K03156]
101117421  PSME1; proteasome activator complex subunit 1 [KO:K06696]
100135691  PSME2; proteasome activator complex subunit 2 [KO:K06697]
101106185  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
105611653  proteasome activator complex subunit 3-like [KO:K06698]
114114126  proteasome activator complex subunit 3-like [KO:K06698]
100913152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101112844  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101117117  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101107064  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101102392  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
114110979  heat shock cognate 71 kDa protein-like [KO:K03283]
121815981  heat shock 70 kDa protein 1B [KO:K03283]
101110063  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101122782  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100127209  HSP90AA1; heat shock protein HSP 90-alpha isoform X2 [KO:K04079]
101117797  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100171394  OVAR; MHC class I antigen precursor [KO:K06751]
101107908  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
106990117  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
101107641  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
101119545  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101104866  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
101111694  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101112480  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
114109630  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X6 [KO:K06751]
101105609  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
132658253  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
780447  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101122273  CANX; calnexin isoform X2 [KO:K08054]
443295  B2M; beta-2-microglobulin precursor [KO:K08055]
114108604  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
100302346  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
105609515  calreticulin-like [KO:K08057]
101104396  CALR; calreticulin [KO:K08057]
114114906  LOW QUALITY PROTEIN: calreticulin [KO:K08057]
100170652  TAPBP; tapasin precursor [KO:K08058]
101115580  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
101109491  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101103464  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
101103712  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
101114438  T cell receptor beta variable 7-9 [KO:K10785]
101104266  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X2 [KO:K07980]
101103752  killer cell immunoglobulin-like receptor 2DL3 isoform X3 [KO:K07980]
101112292  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
114108740  putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 isoform X2 [KO:K07980]
106990160  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1 [KO:K07980]
101103380  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1 [KO:K07980]
101104006  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1 [KO:K07980]
101103878  killer cell immunoglobulin-like receptor 3DL1 isoform X1 [KO:K07980]
101123656  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 isoform X1 [KO:K07980]
114117838  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
101105894  putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 [KO:K07980]
101104216  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
114113669  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
114113672  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
114113675  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101123288  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101101976  natural killer cells antigen CD94 [KO:K06516]
101102227  natural killer cells antigen CD94-like isoform X2 [KO:K06516]
100534647  IFI30; gamma-interferon-inducible lysosomal thiol reductase precursor [KO:K08059]
678680  LGMN; legumain isoform X2 [KO:K01369] [EC:3.4.22.34]
780470  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
100144749  DYA; MHC class II antigen DY alpha precursor [KO:K06752]
101108696  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
101108962  DQA; HLA class II histocompatibility antigen, DQ alpha 2 chain precursor [KO:K06752]
101119342  OVAR-DRB1; DLA class II histocompatibility antigen, DR-1 beta chain-like precursor [KO:K06752]
101109747  mamu class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
101108961  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X2 [KO:K06752]
101109219  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101109746  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
101110545  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101116099  HLA class II histocompatibility antigen, DM alpha chain isoform X2 [KO:K06752]
101114758  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101118514  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X2 [KO:K06752]
101120392  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X2 [KO:K06752]
101115073  rano class II histocompatibility antigen, A beta chain isoform X1 [KO:K06752]
101102561  CD74; HLA class II histocompatibility antigen gamma chain isoform X2 [KO:K06505]
780510  procathepsin L [KO:K01365] [EC:3.4.22.15]
101113725  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
780472  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
443509  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
101106564  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101115494  RFX5; DNA-binding protein RFX5 isoform X2 [KO:K08061]
101105568  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
105612445  RFXAP; regulatory factor X-associated protein isoform X1 [KO:K08063]
443118  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101104434  NFYA; nuclear transcription factor Y subunit alpha isoform X12 [KO:K08064]
101112718  NFYB; nuclear transcription factor Y subunit beta isoform X3 [KO:K08065]
101102681  NFYC; nuclear transcription factor Y subunit gamma isoform X4 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
oas03050  Proteasome
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
KO pathway
ko04612   
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