KEGG   PATHWAY: ocu03440
Entry
ocu03440                    Pathway                                
Name
Homologous recombination - Oryctolagus cuniculus (rabbit)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ocu03440  Homologous recombination
ocu03440

Other DBs
GO: 0000724
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008866  SSBP1; single-stranded DNA-binding protein, mitochondrial precursor [KO:K03111]
100342744  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
100357130  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
127490310  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
100328725  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
100356946  MRE11; double-strand break repair protein MRE11 [KO:K10865]
100352398  nibrin isoform X1 [KO:K10867]
100349299  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100347269  breast cancer type 1 susceptibility protein isoform X2 [KO:K10605] [EC:2.3.2.27]
100340914  BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
100353053  LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like [KO:K20773] [EC:3.1.-.-]
100354690  DNA endonuclease RBBP8 isoform X4 [KO:K20773] [EC:3.1.-.-]
100359326  LOW QUALITY PROTEIN: Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
100349197  DNA topoisomerase 2-binding protein 1 [KO:K10728]
100350582  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X2 [KO:K20774]
100354766  BRCA1-A complex subunit RAP80 isoform X2 [KO:K20775]
100347469  BABAM2; BRISC and BRCA1-A complex member 2 isoform X2 [KO:K12173]
100339276  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
100356031  partner and localizer of BRCA2 isoform X1 [KO:K10897]
100355331  breast cancer type 2 susceptibility protein isoform X2 [KO:K08775]
108178368  26S proteasome complex subunit SEM1 [KO:K10881]
108176933  26S proteasome complex subunit SEM1-like [KO:K10881]
103348357  synaptonemal complex protein 3 isoform X2 [KO:K19528]
100341460  replication protein A 70 kDa DNA-binding subunit [KO:K07466]
100347550  replication protein A 32 kDa subunit isoform X1 [KO:K10739]
100358262  replication protein A 14 kDa subunit isoform X2 [KO:K10740]
103351965  LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741]
100008661  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
100350648  DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
100351948  DNA repair protein RAD51 homolog 2 isoform X8 [KO:K10869]
100339674  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
100357424  DNA repair protein RAD51 homolog 4 [KO:K10871]
100342809  DNA repair protein XRCC2 [KO:K10879]
100354479  DNA repair protein XRCC3 [KO:K10880]
100340671  DNA repair and recombination protein RAD54-like isoform X1 [KO:K10875] [EC:5.6.2.-]
100354266  DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
100358263  DNA polymerase delta subunit 2 [KO:K02328]
100357626  DNA polymerase delta subunit 3 isoform X2 [KO:K03504]
100356010  DNA polymerase delta subunit 4 [KO:K03505]
100345123  recQ-like DNA helicase BLM isoform X1 [KO:K10901] [EC:5.6.2.4]
100345272  DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
100341582  LOW QUALITY PROTEIN: crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
127482699  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
100341377  crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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