Entry
Name
Homologous recombination - Oryctolagus cuniculus (rabbit)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene
100008866 SSBP1; single-stranded DNA-binding protein, mitochondrial precursor [KO:K03111 ]
100342744 single-stranded DNA-binding protein, mitochondrial-like [KO:K03111 ]
100357130 single-stranded DNA-binding protein, mitochondrial-like [KO:K03111 ]
127490310 single-stranded DNA-binding protein, mitochondrial-like [KO:K03111 ]
100353053 LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like [KO:K20773 ] [EC:3.1.-.-]
100350582 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X2 [KO:K20774 ]
100347469 BABAM2; BRISC and BRCA1-A complex member 2 isoform X2 [KO:K12173 ]
100355331 breast cancer type 2 susceptibility protein isoform X2 [KO:K08775 ]
103351965 LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741 ]
100340671 DNA repair and recombination protein RAD54-like isoform X1 [KO:K10875 ] [EC:5.6.2.-]
100354266 DNA repair and recombination protein RAD54B isoform X1 [KO:K10877 ] [EC:5.6.2.-]
100341582 LOW QUALITY PROTEIN: crossover junction endonuclease MUS81 [KO:K08991 ] [EC:3.1.22.-]
127482699 crossover junction endonuclease MUS81 isoform X1 [KO:K08991 ] [EC:3.1.22.-]
Reference
Authors
Maloisel L, Fabre F, Gangloff S.
Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal
Reference
Authors
Haruta-Takahashi N, Iwasaki H.
Title
[Recombination mediators]
Journal
Seikagaku 79:449-53 (2007)
Reference
Authors
Ouyang KJ, Woo LL, Ellis NA.
Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal
Reference
Authors
Kawabata M, Kawabata T, Nishibori M.
Title
Role of recA/RAD51 family proteins in mammals.
Journal
Reference
Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title
Mitotic recombination in Saccharomyces cerevisiae.
Journal
Reference
Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title
Rad54: the Swiss Army knife of homologous recombination?
Journal
Reference
Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title
Recombination proteins and rescue of arrested replication forks.
Journal
KO pathway
LinkDB
All DBs