KEGG   PATHWAY: omm03460
Entry
omm03460                    Pathway                                
Name
Fanconi anemia pathway - Oncorhynchus masou masou (cherry salmon)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
omm03460  Fanconi anemia pathway
omm03460

Other DBs
GO: 0043240
Organism
Oncorhynchus masou masou (cherry salmon) [GN:omm]
Gene
135503676  [KO:K06054]
135503832  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
135503968  [KO:K10892]
135504841  [KO:K10605] [EC:2.3.2.27]
135505900  [KO:K04482]
135506046  [KO:K02350] [EC:2.7.7.7]
135508308  [KO:K06054]
135509072  faap24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
135509205  fanci; Fanconi anemia group I protein [KO:K10895]
135509222  [KO:K15361]
135509332  blm; recQ-like DNA helicase BLM isoform X1 [KO:K10901] [EC:5.6.2.4]
135509444  [KO:K10888]
135510235  mus81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
135510750  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
135510817  mlh1; LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh1 [KO:K08734]
135511006  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
135511019  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
135511791  [KO:K03165] [EC:5.6.2.1]
135511868  [KO:K03165] [EC:5.6.2.1]
135512096  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
135512548  [KO:K06054]
135513174  usp1; ubiquitin carboxyl-terminal hydrolase 1 [KO:K11832] [EC:3.4.19.12]
135513979  [KO:K03511] [EC:2.7.7.7]
135514655  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
135515492  poln; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
135517296  [KO:K15361]
135520070  [KO:K10739]
135522424  [KO:K10739]
135522884  [KO:K15361]
135523629  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
135523643  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
135523688  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
135523918  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
135524745  [KO:K06054]
135526097  fancm; Fanconi anemia group M protein isoform X1 [KO:K10896]
135526857  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
135527380  [KO:K06054]
135534933  poli; DNA polymerase iota isoform X1 [KO:K03510] [EC:2.7.7.7]
135535160  slx4; LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4 [KO:K10484]
135538670  [KO:K10892]
135538756  [KO:K03165] [EC:5.6.2.1]
135539937  fancd2; Fanconi anemia group D2 protein [KO:K10891]
135540284  cenps; centromere protein S [KO:K11511]
135541295  atrip; ATR-interacting protein [KO:K10905]
135542536  fancg; Fanconi anemia group G protein [KO:K10894]
135542709  polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
135543391  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
135544328  fancc; Fanconi anemia group C protein [KO:K10890]
135546466  [KO:K07466]
135547346  rev1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
135547450  fancb; Fanconi anemia group B protein [KO:K10889]
135547704  [KO:K10849]
135547773  [KO:K10849]
135550750  [KO:K10870]
135552024  [KO:K10740]
135552846  [KO:K15362] [EC:5.6.2.3]
135552943  [KO:K07466]
135553296  [KO:K10739]
135554682  [KO:K15360]
135554683  [KO:K15360]
135555169  [KO:K10893]
135555170  [KO:K10893]
135556727  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
135557514  rev3l; DNA polymerase zeta catalytic subunit isoform X1 [KO:K02350] [EC:2.7.7.7]
135557663  [KO:K04482]
135558150  [KO:K06054]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
omm03430  Mismatch repair
omm03440  Homologous recombination
KO pathway
ko03460   

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