KEGG   PATHWAY: pag00260
Entry
pag00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa LESB58
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pag00260  Glycine, serine and threonine metabolism
pag00260

Module
pag_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pag00260]
pag_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pag00260]
pag_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pag00260]
pag_M00555  Betaine biosynthesis, choline => betaine [PATH:pag00260]
pag_M00621  Glycine cleavage system [PATH:pag00260]
pag_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pag00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa LESB58 [GN:pag]
Gene
PLES_44121  lysC; aspartate kinase alpha and beta chain [KO:K00928] [EC:2.7.2.4]
PLES_19421  asd; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PLES_12441  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PLES_58911  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
PLES_35721  thrH; homoserine kinase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
PLES_12451  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PLES_44141  possible threonine aldolase [KO:K01620] [EC:4.1.2.48]
PLES_58081  ltaA; low specificity l-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PLES_49871  glyA3; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PLES_58101  glyA1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PLES_28501  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PLES_50111  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PLES_10811  probable 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
PLES_42711  Putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
PLES_39131  putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PLES_55211  pgm; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PLES_03121  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PLES_19011  serC; 3-phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PLES_53461  probable phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PLES_04191  putative monoamine oxidase [KO:K00274] [EC:1.4.3.4]
PLES_28491  gcvP2; glycine cleavage system protein P2 [KO:K00281] [EC:1.4.4.2]
PLES_56071  gcvP1; glycine cleavage system protein P1 [KO:K00281] [EC:1.4.4.2]
PLES_56091  gcvT1; glycine-cleavage system protein T1 [KO:K00605] [EC:2.1.2.10]
PLES_28521  gcvT2; glycine cleavage system protein T2 [KO:K00605] [EC:2.1.2.10]
PLES_30541  lpdV; lipoamide dehydrogenase-Val [KO:K00382] [EC:1.8.1.4]
PLES_37401  lpdG; lipoamide dehydrogenase-glc [KO:K00382] [EC:1.8.1.4]
PLES_26171  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PLES_52141  lpd3; dihydrolipoamide dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
PLES_56081  gcvH1; glycine cleavage system protein H1 [KO:K02437]
PLES_28481  gcvH2; glycine cleavage system protein H2 [KO:K02437]
PLES_51811  putative glycine cleavage system H protein [KO:K02437]
PLES_50781  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
PLES_57671  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PLES_57681  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PLES_58061  probable ring hydroxylating dioxygenase, alpha-subunit [KO:K00479] [EC:1.14.13.251]
PLES_58071  probable ferredoxin [KO:K21832] [EC:1.14.13.251]
PLES_57941  probable FMN oxidoreductase [KO:K21833] [EC:1.5.7.3]
PLES_57951  probable ferredoxin [KO:K21834]
PLES_57961  probable electron transfer flavoprotein alpha subunit [KO:K25960]
PLES_57971  putative electron transfer flavoprotein, beta subunit [KO:K25961]
PLES_58131  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PLES_58111  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PLES_58141  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PLES_58121  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PLES_03971  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
PLES_03981  probable cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
PLES_28511  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PLES_57751  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PLES_44671  hypothetical [KO:K01754] [EC:4.3.1.19]
PLES_03281  ilvA1; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
PLES_38551  ilvA2; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
PLES_17071  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
PLES_00341  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PLES_00351  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PLES_28831  pvdH; L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, PvdH [KO:K00836] [EC:2.6.1.76]
PLES_30951  Putative aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pag00010  Glycolysis / Gluconeogenesis
pag00020  Citrate cycle (TCA cycle)
pag00230  Purine metabolism
pag00250  Alanine, aspartate and glutamate metabolism
pag00270  Cysteine and methionine metabolism
pag00290  Valine, leucine and isoleucine biosynthesis
pag00300  Lysine biosynthesis
pag00330  Arginine and proline metabolism
pag00460  Cyanoamino acid metabolism
pag00470  D-Amino acid metabolism
pag00564  Glycerophospholipid metabolism
pag00600  Sphingolipid metabolism
pag00620  Pyruvate metabolism
pag00630  Glyoxylate and dicarboxylate metabolism
pag00640  Propanoate metabolism
pag00680  Methane metabolism
pag00860  Porphyrin metabolism
pag00920  Sulfur metabolism
KO pathway
ko00260   
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