KEGG   PATHWAY: aag00600
Entry
aag00600                    Pathway                                
Name
Sphingolipid metabolism - Aedes aegypti (yellow fever mosquito)
Class
Metabolism; Lipid metabolism
Pathway map
aag00600  Sphingolipid metabolism
aag00600

Module
aag_M00094  Ceramide biosynthesis [PATH:aag00600]
aag_M00099  Sphingosine biosynthesis [PATH:aag00600]
aag_M00100  Sphingosine degradation [PATH:aag00600]
Other DBs
GO: 0006665
Organism
Aedes aegypti (yellow fever mosquito) [GN:aag]
Gene
5565891  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
5573625  serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
5579897  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
5571461  ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
5568678  neutral ceramidase [KO:K12349] [EC:3.5.1.23]
5568674  neutral ceramidase [KO:K12349] [EC:3.5.1.23]
5571646  LOW QUALITY PROTEIN: alkaline ceramidase [KO:K01441] [EC:3.5.1.23]
5577178  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
5565303  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
5578088  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
5567918  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
5574574  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
5571519  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
5573139  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
5576467  sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
5579301  ceramide kinase [KO:K04715] [EC:2.7.1.138]
5569026  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
5568635  uncharacterized protein T28D9.3 isoform X1 [KO:K01080] [EC:3.1.3.4]
5568636  putative phosphatidate phosphatase isoform X1 [KO:K01080] [EC:3.1.3.4]
5573802  sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
5563823  ceramide phosphoethanolamine synthase [KO:K26283] [EC:2.7.8.48]
5570737  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110673984  sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]
5577517  LOW QUALITY PROTEIN: sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
5565442  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
5578914  glucosylceramidase [KO:K01201] [EC:3.2.1.45]
5570898  non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
5565031  beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
5565066  beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
5565073  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
5565699  beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
5565215  chitooligosaccharidolytic beta-N-acetylglucosaminidase isoform X1 [KO:K12373] [EC:3.2.1.52]
5569687  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
5568043  uncharacterized protein LOC5568043 [KO:K12383]
5576894  uncharacterized protein LOC5576894 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
aag00260  Glycine, serine and threonine metabolism
aag00601  Glycosphingolipid biosynthesis - lacto and neolacto series
aag00603  Glycosphingolipid biosynthesis - globo and isoglobo series
aag00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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